A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS.
Background: New data suggests that joint damage in Knee Osteoarthritis (KOA) may be caused by systemic factors like adipose tissue products; Adipokines, which may provide a metabolic link between obesity & KOA. Recently, one of the known adipokines named LEPTIN has been linked to KOA because it...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2008-10-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1260 |
| _version_ | 1797331174850297856 |
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| author | Kismat M. Turki Mohammed H. Alosami Zina H. Abdul-Qahar |
| author_facet | Kismat M. Turki Mohammed H. Alosami Zina H. Abdul-Qahar |
| author_sort | Kismat M. Turki |
| collection | DOAJ |
| description | Background: New data suggests that joint damage in Knee Osteoarthritis (KOA) may be caused by systemic factors like adipose tissue products; Adipokines, which may provide a
metabolic link between obesity & KOA. Recently, one of the known adipokines named LEPTIN has been linked to KOA because it can be detected in serum & synovial fluid of
patients with KOA.
Objective: To evaluate the contribution of Leptin & serum lipids to the pathophysiology of Osteoarthritis in Iraqi patients with Knee OA.
Subjects& Methods: The study was carried on 90 subjects divided into four groups: Knee Osteoarthritis cases group (n=60). Control group (n=30). Obese subjects group (n=60).
Non-obese subjects group (n=30). KOA cases were diagnosed clinically whereas obesity was specified by BMI ≥25kg/m2. For all subjects studied measurements of fasting serum leptin and lipid profile have been done.
Results: Mean serum leptin level was significantly higher in KOA cases compared to control group (P<0.001), and higher in obese than non-obese subjects (P<0.001). Serum leptin level
also showed a strong positive correlation with BMI (r=0.501, P<0.01).
Conclusions: Leptin may play an important role in the pathogenesis of KOA. In addition abnormal lipid profile and obesity are important risk factors for KOA. |
| first_indexed | 2024-03-08T07:30:41Z |
| format | Article |
| id | doaj.art-f1fab168739f44b1bbdbf25814478b31 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T07:30:41Z |
| publishDate | 2008-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-f1fab168739f44b1bbdbf25814478b312024-02-02T20:48:44ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572008-10-0150310.32007/1260%g372-376A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS.Kismat M. Turki0Mohammed H. Alosami1Zina H. Abdul-Qahar2Baghdad University, College of Medicine, Department of Physiological Chemistry.Baghdad Teaching Hospital, Medical Department, Rheumatology Unit.Baghdad University, College of Medicine, Department of Physiological Chemistry.Background: New data suggests that joint damage in Knee Osteoarthritis (KOA) may be caused by systemic factors like adipose tissue products; Adipokines, which may provide a metabolic link between obesity & KOA. Recently, one of the known adipokines named LEPTIN has been linked to KOA because it can be detected in serum & synovial fluid of patients with KOA. Objective: To evaluate the contribution of Leptin & serum lipids to the pathophysiology of Osteoarthritis in Iraqi patients with Knee OA. Subjects& Methods: The study was carried on 90 subjects divided into four groups: Knee Osteoarthritis cases group (n=60). Control group (n=30). Obese subjects group (n=60). Non-obese subjects group (n=30). KOA cases were diagnosed clinically whereas obesity was specified by BMI ≥25kg/m2. For all subjects studied measurements of fasting serum leptin and lipid profile have been done. Results: Mean serum leptin level was significantly higher in KOA cases compared to control group (P<0.001), and higher in obese than non-obese subjects (P<0.001). Serum leptin level also showed a strong positive correlation with BMI (r=0.501, P<0.01). Conclusions: Leptin may play an important role in the pathogenesis of KOA. In addition abnormal lipid profile and obesity are important risk factors for KOA.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1260Knee Osteoarthritis, Obesity, Leptin. |
| spellingShingle | Kismat M. Turki Mohammed H. Alosami Zina H. Abdul-Qahar A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS. مجلة كلية الطب Knee Osteoarthritis, Obesity, Leptin. |
| title | A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS. |
| title_full | A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS. |
| title_fullStr | A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS. |
| title_full_unstemmed | A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS. |
| title_short | A STUDY OF LEPTIN & LIPID PROFILE IN A SAMPLE OF IRAQI PATIENTS WITH KNEE OSTEOARTHRITIS. |
| title_sort | study of leptin lipid profile in a sample of iraqi patients with knee osteoarthritis |
| topic | Knee Osteoarthritis, Obesity, Leptin. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1260 |
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