The role of magnetic field in the biopharmaceutical production: Current perspectives
Current scientific evidence on the influence of magnetic field on mammalian cell lines used for industrial production of biopharmaceuticals, on human cell lines and on potential cell lines for the biopharmaceutical production is presented in this review. A novel magnetic coupling induced agitation c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Biotechnology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215017X18303072 |
| _version_ | 1828487508506181632 |
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| author | Alina Rekena Elina Didrihsone Kristine Vegere |
| author_facet | Alina Rekena Elina Didrihsone Kristine Vegere |
| author_sort | Alina Rekena |
| collection | DOAJ |
| description | Current scientific evidence on the influence of magnetic field on mammalian cell lines used for industrial production of biopharmaceuticals, on human cell lines and on potential cell lines for the biopharmaceutical production is presented in this review. A novel magnetic coupling induced agitation could be the best solution to eliminate sources of contamination in stirred tank bioreactors which is especially important for mammalian cell cultures. Nevertheless, the side effect of magnetically-coupled stirring mechanism is that cells are exposed to the generated magnetic field. The influence of magnetic field on biological systems has been investigated for several decades. The research continues nowadays as well, investigating the influence of various types of magnetic field in a variety of experimental setups. In the context of bioreactors, only the lower frequencies and intensities of the magnetic field are relevant. Keywords: Time-varying magnetic field, Static magnetic field, Magnetic field influence, Mammalian cells, Biopharmaceuticals |
| first_indexed | 2024-12-11T09:51:55Z |
| format | Article |
| id | doaj.art-f1faf121b35b49b5be56aa4dce84b59b |
| institution | Directory Open Access Journal |
| issn | 2215-017X |
| language | English |
| last_indexed | 2024-12-11T09:51:55Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biotechnology Reports |
| spelling | doaj.art-f1faf121b35b49b5be56aa4dce84b59b2022-12-22T01:12:23ZengElsevierBiotechnology Reports2215-017X2019-06-0122The role of magnetic field in the biopharmaceutical production: Current perspectivesAlina Rekena0Elina Didrihsone1Kristine Vegere2Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka 3, Riga, LV1007, Latvia; Corresponding author at: Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre of Riga Technical University, Pulka 3, Riga, LV1007, Latvia.Bioengineering Laboratory, Latvian State Institute of Wood Chemistry, Dzerbenes 27, Riga, LV1006, Latvia; Institute of Polymer Materials, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Paula Valdena 3, Riga, LV-1048, LatviaRudolfs Cimdins Riga Biomaterials Innovations and Development Centre of RTU, Institute of General Chemical Engineering, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Pulka 3, Riga, LV1007, Latvia; Water Research Laboratory, Faculty of Civil Engineering, Riga Technical University, Paula Valdena 1-205, Riga, LV1048, LatviaCurrent scientific evidence on the influence of magnetic field on mammalian cell lines used for industrial production of biopharmaceuticals, on human cell lines and on potential cell lines for the biopharmaceutical production is presented in this review. A novel magnetic coupling induced agitation could be the best solution to eliminate sources of contamination in stirred tank bioreactors which is especially important for mammalian cell cultures. Nevertheless, the side effect of magnetically-coupled stirring mechanism is that cells are exposed to the generated magnetic field. The influence of magnetic field on biological systems has been investigated for several decades. The research continues nowadays as well, investigating the influence of various types of magnetic field in a variety of experimental setups. In the context of bioreactors, only the lower frequencies and intensities of the magnetic field are relevant. Keywords: Time-varying magnetic field, Static magnetic field, Magnetic field influence, Mammalian cells, Biopharmaceuticalshttp://www.sciencedirect.com/science/article/pii/S2215017X18303072 |
| spellingShingle | Alina Rekena Elina Didrihsone Kristine Vegere The role of magnetic field in the biopharmaceutical production: Current perspectives Biotechnology Reports |
| title | The role of magnetic field in the biopharmaceutical production: Current perspectives |
| title_full | The role of magnetic field in the biopharmaceutical production: Current perspectives |
| title_fullStr | The role of magnetic field in the biopharmaceutical production: Current perspectives |
| title_full_unstemmed | The role of magnetic field in the biopharmaceutical production: Current perspectives |
| title_short | The role of magnetic field in the biopharmaceutical production: Current perspectives |
| title_sort | role of magnetic field in the biopharmaceutical production current perspectives |
| url | http://www.sciencedirect.com/science/article/pii/S2215017X18303072 |
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