Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats
Abstract Background Chronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature indicates that CKD is associated with profound lipid disorders due to the dysregulation of lipoprotein metabolism which progresses kidney disease...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-11-01
|
| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12882-019-1621-6 |
| _version_ | 1818558158947221504 |
|---|---|
| author | Hardik Ghelani Valentina Razmovski-Naumovski Dennis Chang Srinivas Nammi |
| author_facet | Hardik Ghelani Valentina Razmovski-Naumovski Dennis Chang Srinivas Nammi |
| author_sort | Hardik Ghelani |
| collection | DOAJ |
| description | Abstract Background Chronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature indicates that CKD is associated with profound lipid disorders due to the dysregulation of lipoprotein metabolism which progresses kidney disease. The objective of this study is to evaluate the protective effects of curcumin on dyslipidaemia associated with adenine-induced chronic kidney disease in rats. Methods Male SD rats (n = 29) were divided into 5 groups for 24 days: normal control (n = 5, normal diet), CKD control (n = 6, 0.75% w/w adenine-supplemented diet), CUR 50 (n = 6, 50 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet), CUR 100 (n = 6, 100 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet), and CUR 150 (n = 6, 150 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet). The serum and tissue lipid profile, as well as the kidney function test, were measured using commercial diagnostic kits. Results The marked rise in total cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, triglycerides and free fatty acids in serum, as well as hepatic cholesterol, triglyceride and free fatty acids of CKD control rats were significantly protected by curcumin co-treatment (at the dose of 50, 100 and 150 mg/kg). Furthermore, curcumin significantly increased the serum high-density lipoprotein (HDL) cholesterol compared to the CKD control rats but did not attenuate the CKD-induced weight retardation. Mathematical computational analysis revealed that curcumin significantly reduced indicators for the risk of atherosclerotic lesions (atherogenic index) and coronary atherogenesis (coronary risk index). In addition, curcumin improved kidney function as shown by the reduction in proteinuria and improvement in creatinine clearance. Conclusion The results provide new scientific evidence for the use of curcumin in CKD-associated dyslipidaemia and substantiates the traditional use of curcumin in preventing kidney damage. |
| first_indexed | 2024-12-14T00:09:05Z |
| format | Article |
| id | doaj.art-f1fb37038acb40468afb432858b2f057 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-14T00:09:05Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f1fb37038acb40468afb432858b2f0572022-12-21T23:25:50ZengBMCBMC Nephrology1471-23692019-11-0120111310.1186/s12882-019-1621-6Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley ratsHardik Ghelani0Valentina Razmovski-Naumovski1Dennis Chang2Srinivas Nammi3School of Science and Health, Western Sydney UniversitySchool of Science and Health, Western Sydney UniversitySchool of Science and Health, Western Sydney UniversitySchool of Science and Health, Western Sydney UniversityAbstract Background Chronic kidney disease (CKD), including nephrotic syndrome, is a major cause of cardiovascular morbidity and mortality. The literature indicates that CKD is associated with profound lipid disorders due to the dysregulation of lipoprotein metabolism which progresses kidney disease. The objective of this study is to evaluate the protective effects of curcumin on dyslipidaemia associated with adenine-induced chronic kidney disease in rats. Methods Male SD rats (n = 29) were divided into 5 groups for 24 days: normal control (n = 5, normal diet), CKD control (n = 6, 0.75% w/w adenine-supplemented diet), CUR 50 (n = 6, 50 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet), CUR 100 (n = 6, 100 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet), and CUR 150 (n = 6, 150 mg/kg/day curcumin + 0.75% w/w adenine-supplemented diet). The serum and tissue lipid profile, as well as the kidney function test, were measured using commercial diagnostic kits. Results The marked rise in total cholesterol, low-density lipoprotein (LDL) cholesterol, very low-density lipoprotein (VLDL) cholesterol, triglycerides and free fatty acids in serum, as well as hepatic cholesterol, triglyceride and free fatty acids of CKD control rats were significantly protected by curcumin co-treatment (at the dose of 50, 100 and 150 mg/kg). Furthermore, curcumin significantly increased the serum high-density lipoprotein (HDL) cholesterol compared to the CKD control rats but did not attenuate the CKD-induced weight retardation. Mathematical computational analysis revealed that curcumin significantly reduced indicators for the risk of atherosclerotic lesions (atherogenic index) and coronary atherogenesis (coronary risk index). In addition, curcumin improved kidney function as shown by the reduction in proteinuria and improvement in creatinine clearance. Conclusion The results provide new scientific evidence for the use of curcumin in CKD-associated dyslipidaemia and substantiates the traditional use of curcumin in preventing kidney damage.http://link.springer.com/article/10.1186/s12882-019-1621-6CurcuminChronic kidney diseaseDyslipidaemiaAdenine-induced chronic kidney disease |
| spellingShingle | Hardik Ghelani Valentina Razmovski-Naumovski Dennis Chang Srinivas Nammi Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats BMC Nephrology Curcumin Chronic kidney disease Dyslipidaemia Adenine-induced chronic kidney disease |
| title | Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats |
| title_full | Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats |
| title_fullStr | Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats |
| title_full_unstemmed | Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats |
| title_short | Chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine-induced chronic kidney disease in Sprague-Dawley rats |
| title_sort | chronic treatment of curcumin improves hepatic lipid metabolism and alleviates the renal damage in adenine induced chronic kidney disease in sprague dawley rats |
| topic | Curcumin Chronic kidney disease Dyslipidaemia Adenine-induced chronic kidney disease |
| url | http://link.springer.com/article/10.1186/s12882-019-1621-6 |
| work_keys_str_mv | AT hardikghelani chronictreatmentofcurcuminimproveshepaticlipidmetabolismandalleviatestherenaldamageinadenineinducedchronickidneydiseaseinspraguedawleyrats AT valentinarazmovskinaumovski chronictreatmentofcurcuminimproveshepaticlipidmetabolismandalleviatestherenaldamageinadenineinducedchronickidneydiseaseinspraguedawleyrats AT dennischang chronictreatmentofcurcuminimproveshepaticlipidmetabolismandalleviatestherenaldamageinadenineinducedchronickidneydiseaseinspraguedawleyrats AT srinivasnammi chronictreatmentofcurcuminimproveshepaticlipidmetabolismandalleviatestherenaldamageinadenineinducedchronickidneydiseaseinspraguedawleyrats |