Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk
Ruminants’ milk is commonly used for supplying nutrients to infants when breast milk is unavailable or limited. Previous studies have highlighted the differences between ruminants’ milk composition, digestion, absorption, and fermentation. However, whether consuming different ruminants’ milk impact...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1242301/full |
| _version_ | 1797672722668453888 |
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| author | Ankita Jena Ankita Jena Ankita Jena Carlos A. Montoya Carlos A. Montoya Karl Fraser Karl Fraser Karl Fraser Caroline Giezenaar Caroline Giezenaar Wayne Young Wayne Young Wayne Young Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Ryan N. Dilger Debashree Roy Warren C. McNabb Warren C. McNabb Nicole C. Roy Nicole C. Roy Nicole C. Roy |
| author_facet | Ankita Jena Ankita Jena Ankita Jena Carlos A. Montoya Carlos A. Montoya Karl Fraser Karl Fraser Karl Fraser Caroline Giezenaar Caroline Giezenaar Wayne Young Wayne Young Wayne Young Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Ryan N. Dilger Debashree Roy Warren C. McNabb Warren C. McNabb Nicole C. Roy Nicole C. Roy Nicole C. Roy |
| author_sort | Ankita Jena |
| collection | DOAJ |
| description | Ruminants’ milk is commonly used for supplying nutrients to infants when breast milk is unavailable or limited. Previous studies have highlighted the differences between ruminants’ milk composition, digestion, absorption, and fermentation. However, whether consuming different ruminants’ milk impact the appearance of the circulatory blood metabolites in the early postnatal life is not well understood. The analysis conducted here aimed to determine the effect of feeding exclusively whole milk from bovine, caprine or ovine species to pigs, approximately 7 days-old for 15 days, on circulatory blood plasma metabolites. Relative intensities of plasma metabolites were detected using a liquid chromatography-mass spectrometry based metabolomic approach. Seven polar and 83 non-polar (lipids) metabolites in plasma were significantly different (false discovery rate < 0.05) between milk treatments. These included polar metabolites involved in amino acid metabolism and lipids belonging to phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, and triglycerides. Compared to the caprine or bovine milk group, the relative intensities of polar metabolites and unsaturated triglycerides were higher in the peripheral circulation of the ovine milk group. In contrast, relative intensities of saturated triglycerides and phosphatidylcholine were higher in the bovine milk group compared to the ovine or caprine milk group. In addition, correlations were identified between amino acid and lipid intake and their appearance in peripheral blood circulation. The results highlighted that consuming different ruminants’ milk influences the plasma appearance of metabolites, especially lipids, that may contribute to early postnatal life development in pigs. |
| first_indexed | 2024-03-11T21:34:22Z |
| format | Article |
| id | doaj.art-f1fc1027b45548f09eb6028de6e0eb49 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T21:34:22Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-f1fc1027b45548f09eb6028de6e0eb492023-09-27T04:44:15ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-09-011010.3389/fnut.2023.12423011242301Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milkAnkita Jena0Ankita Jena1Ankita Jena2Carlos A. Montoya3Carlos A. Montoya4Karl Fraser5Karl Fraser6Karl Fraser7Caroline Giezenaar8Caroline Giezenaar9Wayne Young10Wayne Young11Wayne Young12Jane A. Mullaney13Jane A. Mullaney14Jane A. Mullaney15Ryan N. Dilger16Debashree Roy17Warren C. McNabb18Warren C. McNabb19Nicole C. Roy20Nicole C. Roy21Nicole C. Roy22Riddet Institute, Massey University, Palmerston North, New ZealandSchool of Food and Advanced Technology, College of Sciences, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandFood Experience and Sensory Testing (FEAST) Laboratory, School of Food and Advanced Technology, Massey University, Palmerston North, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandAgResearch, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandDepartment of Animal Sciences, University of Illinois, Urbana, IL, United StatesRiddet Institute, Massey University, Palmerston North, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandRiddet Institute, Massey University, Palmerston North, New ZealandHigh-Value Nutrition National Science Challenge, Auckland, New ZealandDepartment of Human Nutrition, University of Otago, Dunedin, New ZealandRuminants’ milk is commonly used for supplying nutrients to infants when breast milk is unavailable or limited. Previous studies have highlighted the differences between ruminants’ milk composition, digestion, absorption, and fermentation. However, whether consuming different ruminants’ milk impact the appearance of the circulatory blood metabolites in the early postnatal life is not well understood. The analysis conducted here aimed to determine the effect of feeding exclusively whole milk from bovine, caprine or ovine species to pigs, approximately 7 days-old for 15 days, on circulatory blood plasma metabolites. Relative intensities of plasma metabolites were detected using a liquid chromatography-mass spectrometry based metabolomic approach. Seven polar and 83 non-polar (lipids) metabolites in plasma were significantly different (false discovery rate < 0.05) between milk treatments. These included polar metabolites involved in amino acid metabolism and lipids belonging to phosphatidylcholine, lysophosphatidylcholine, sphingomyelin, and triglycerides. Compared to the caprine or bovine milk group, the relative intensities of polar metabolites and unsaturated triglycerides were higher in the peripheral circulation of the ovine milk group. In contrast, relative intensities of saturated triglycerides and phosphatidylcholine were higher in the bovine milk group compared to the ovine or caprine milk group. In addition, correlations were identified between amino acid and lipid intake and their appearance in peripheral blood circulation. The results highlighted that consuming different ruminants’ milk influences the plasma appearance of metabolites, especially lipids, that may contribute to early postnatal life development in pigs.https://www.frontiersin.org/articles/10.3389/fnut.2023.1242301/fullmetabolomicsearly lifenutritionruminant milkpigsplasma |
| spellingShingle | Ankita Jena Ankita Jena Ankita Jena Carlos A. Montoya Carlos A. Montoya Karl Fraser Karl Fraser Karl Fraser Caroline Giezenaar Caroline Giezenaar Wayne Young Wayne Young Wayne Young Jane A. Mullaney Jane A. Mullaney Jane A. Mullaney Ryan N. Dilger Debashree Roy Warren C. McNabb Warren C. McNabb Nicole C. Roy Nicole C. Roy Nicole C. Roy Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk Frontiers in Nutrition metabolomics early life nutrition ruminant milk pigs plasma |
| title | Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk |
| title_full | Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk |
| title_fullStr | Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk |
| title_full_unstemmed | Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk |
| title_short | Metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine, caprine or ovine milk |
| title_sort | metabolite profiling of peripheral blood plasma in pigs in early postnatal life fed whole bovine caprine or ovine milk |
| topic | metabolomics early life nutrition ruminant milk pigs plasma |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1242301/full |
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