New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer
Background and AimsAttention is increasingly being paid to family history of pancreatic cancer (PC) as a risk factor for developing PC. It is mandatory to develop a screening system for early detection of PC; however, the relationship between a family history of PC and the incidence of pancreatic ab...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.928182/full |
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| author | Reiko Ashida Reiko Ashida Tatsuya Ioka Tatsuya Ioka Ryoji Takada Nobuyasu Fukutake Nobuyasu Fukutake Kenji Ikezawa Kazuyoshi Ohkawa Shigenori Nagata Hidenori Takahashi Hidenori Takahashi |
| author_facet | Reiko Ashida Reiko Ashida Tatsuya Ioka Tatsuya Ioka Ryoji Takada Nobuyasu Fukutake Nobuyasu Fukutake Kenji Ikezawa Kazuyoshi Ohkawa Shigenori Nagata Hidenori Takahashi Hidenori Takahashi |
| author_sort | Reiko Ashida |
| collection | DOAJ |
| description | Background and AimsAttention is increasingly being paid to family history of pancreatic cancer (PC) as a risk factor for developing PC. It is mandatory to develop a screening system for early detection of PC; however, the relationship between a family history of PC and the incidence of pancreatic abnormalities, such as pancreatic cyst and chronic pancreatitis (CP), in the Japanese population remains unknown.Patients and MethodsIndividuals with a family history of PC were prospectively enrolled in a screening program using forward-viewing radial endoscopic ultrasound (FR-EUS) and magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) as the diagnostic modalities.ResultsIn total, forty-three individuals in 37 families were enrolled (mean age, 54 years). All individuals underwent FR-EUS and MRI with no complications. FR-EUS revealed resectable PC (n = 1, 2.3%), pancreatic cysts (n = 24, 55.8%), intraductal papillary mucinous neoplasm (IPMN; n = 13, 30.2%), and early CP-like appearance (n = 15, 34.9%). The detection rate of early CP-like appearance was significantly higher by EUS than by MRI. Pancreatic cysts and IPMN detected by FR-EUS were significantly correlated to age (≥60 years) and less correlated to men (hazard ratio [HR] 22.4; 95% confidence interval [CI], 2.10–236.0; p < 0.01 and HR 0.092; 95% CI, 0.01–0.83; p = 0.033, respectively). Early CP-like appearance detected by FR-EUS was significantly correlated with men and smoking (HR 5.0; 95% CI, 1.3–19.3; p = 0.02 and HR 4.02; 95% CI, 0.991–16.3; p = 0.05, respectively).ConclusionA screening system using FR-EUS and MRI/MRCP for individuals with a family history of PC was useful for identifying curable PC and pancreatic abnormalities. The incidence of pancreatic cysts, such as IPMN and early CP-like appearance, was also high in the Japanese cohort. |
| first_indexed | 2024-04-12T12:29:20Z |
| format | Article |
| id | doaj.art-f1fca14bf701446981e6272089440da6 |
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| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T12:29:20Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj.art-f1fca14bf701446981e6272089440da62022-12-22T03:33:05ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-06-01910.3389/fmed.2022.928182928182New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic CancerReiko Ashida0Reiko Ashida1Tatsuya Ioka2Tatsuya Ioka3Ryoji Takada4Nobuyasu Fukutake5Nobuyasu Fukutake6Kenji Ikezawa7Kazuyoshi Ohkawa8Shigenori Nagata9Hidenori Takahashi10Hidenori Takahashi11Second Department of Internal Medicine, Wakayama Medical University, Wakayama, JapanDepartment of Cancer Survey and Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, JapanDepartment of Cancer Survey and Gastrointestinal Oncology, Osaka International Cancer Institute, Osaka, JapanDepartment of Gastroenterological, Breast and Endocrine Surgery, Yamaguchi University Graduate School of Medicine, Yamaguchi, JapanDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, JapanDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, JapanDepartment of Gastroenterology, Osaka National Hospital, Osaka, JapanDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, JapanDepartment of Hepatobiliary and Pancreatic Oncology, Osaka International Cancer Institute, Osaka, JapanDepartment of Diagnostic Pathology and Cytology, Osaka International Cancer Institute, Osaka, JapanDepartment of Surgery, Osaka International Cancer Institute, Osaka, JapanDepartment of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, JapanBackground and AimsAttention is increasingly being paid to family history of pancreatic cancer (PC) as a risk factor for developing PC. It is mandatory to develop a screening system for early detection of PC; however, the relationship between a family history of PC and the incidence of pancreatic abnormalities, such as pancreatic cyst and chronic pancreatitis (CP), in the Japanese population remains unknown.Patients and MethodsIndividuals with a family history of PC were prospectively enrolled in a screening program using forward-viewing radial endoscopic ultrasound (FR-EUS) and magnetic resonance imaging (MRI) with magnetic resonance cholangiopancreatography (MRCP) as the diagnostic modalities.ResultsIn total, forty-three individuals in 37 families were enrolled (mean age, 54 years). All individuals underwent FR-EUS and MRI with no complications. FR-EUS revealed resectable PC (n = 1, 2.3%), pancreatic cysts (n = 24, 55.8%), intraductal papillary mucinous neoplasm (IPMN; n = 13, 30.2%), and early CP-like appearance (n = 15, 34.9%). The detection rate of early CP-like appearance was significantly higher by EUS than by MRI. Pancreatic cysts and IPMN detected by FR-EUS were significantly correlated to age (≥60 years) and less correlated to men (hazard ratio [HR] 22.4; 95% confidence interval [CI], 2.10–236.0; p < 0.01 and HR 0.092; 95% CI, 0.01–0.83; p = 0.033, respectively). Early CP-like appearance detected by FR-EUS was significantly correlated with men and smoking (HR 5.0; 95% CI, 1.3–19.3; p = 0.02 and HR 4.02; 95% CI, 0.991–16.3; p = 0.05, respectively).ConclusionA screening system using FR-EUS and MRI/MRCP for individuals with a family history of PC was useful for identifying curable PC and pancreatic abnormalities. The incidence of pancreatic cysts, such as IPMN and early CP-like appearance, was also high in the Japanese cohort.https://www.frontiersin.org/articles/10.3389/fmed.2022.928182/fullEUSpancreatic cancerfamily historyearly chronic pancreatitisIPMN |
| spellingShingle | Reiko Ashida Reiko Ashida Tatsuya Ioka Tatsuya Ioka Ryoji Takada Nobuyasu Fukutake Nobuyasu Fukutake Kenji Ikezawa Kazuyoshi Ohkawa Shigenori Nagata Hidenori Takahashi Hidenori Takahashi New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer Frontiers in Medicine EUS pancreatic cancer family history early chronic pancreatitis IPMN |
| title | New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer |
| title_full | New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer |
| title_fullStr | New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer |
| title_full_unstemmed | New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer |
| title_short | New Screening System Using Forward-Viewing Radial Endoscopic Ultrasound and Magnetic Resonance Imaging for High-Risk Individuals With Familial History of Pancreatic Cancer |
| title_sort | new screening system using forward viewing radial endoscopic ultrasound and magnetic resonance imaging for high risk individuals with familial history of pancreatic cancer |
| topic | EUS pancreatic cancer family history early chronic pancreatitis IPMN |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.928182/full |
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