Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia
Background: Rheumatoid arthritis (RA) is a destructive chronic inflammatory disease with intra- and extra-articular manifestations. It is associated with accelerated formation of arteriosclerosis. The aim of this study was to ascertain the correlation between endothelial dysfunction using carotid in...
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| Format: | Article |
| Language: | English |
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Universitas Indonesia
2019-12-01
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| Series: | Makara Journal of Health Research |
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| Online Access: | https://scholarhub.ui.ac.id/mjhr/vol23/iss3/9/ |
| _version_ | 1797884517324685312 |
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| author | Kek Xin Yi Asrul A. Wahab Mohamad Norazrin Mohd Abas Siti Amira Kamarul Abdul Wahid Faridah Hanun Othman Mohd. Shahrir Mohamed Said |
| author_facet | Kek Xin Yi Asrul A. Wahab Mohamad Norazrin Mohd Abas Siti Amira Kamarul Abdul Wahid Faridah Hanun Othman Mohd. Shahrir Mohamed Said |
| author_sort | Kek Xin Yi |
| collection | DOAJ |
| description | Background: Rheumatoid arthritis (RA) is a destructive chronic inflammatory disease with intra- and extra-articular manifestations. It is associated with accelerated formation of arteriosclerosis. The aim of this study was to ascertain the correlation between endothelial dysfunction using carotid intima–media thickness (cIMT) and tumor necrosis factor-alpha (TNF-α) levels among the three main ethnic groups in Malaysia: Malay, Chinese, and Indian. Methods: This cross-sectional study included 23 females with RA belonging to three different ethnic groups who were free from cardiovascular risk factors. Blood sample was taken from each patient to measure serum TNF-α level, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Carotid ultrasonography was performed for cIMT analysis. The Disease Activity Score (DAS)-28 scoring system was used to assess disease activity. Results: Patients’ median age and disease duration were 47 and 5 years, respectively. No thickened cIMT was found in any of the patients. The duration of disease, TNF-α level, cIMT, DAS-28 CRP, and DAS-28 ESR showed no significant correlations in the different ethnic groups (p > 0.05). Conclusion: This study indicates that cIMT and serum TNF-α levels among females with RA in Malaysia may not be affected by ethnicity. |
| first_indexed | 2024-04-10T04:08:53Z |
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| id | doaj.art-f1fd3f6bb1c246e4b5182b14e38e907d |
| institution | Directory Open Access Journal |
| issn | 2356-3664 2356-3656 |
| language | English |
| last_indexed | 2024-04-10T04:08:53Z |
| publishDate | 2019-12-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Journal of Health Research |
| spelling | doaj.art-f1fd3f6bb1c246e4b5182b14e38e907d2023-03-13T03:44:47ZengUniversitas IndonesiaMakara Journal of Health Research2356-36642356-36562019-12-0123317618010.7454/msk.v23i3.1145Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in MalaysiaKek Xin Yi0Asrul A. Wahab1Mohamad Norazrin Mohd Abas2Siti Amira Kamarul Abdul Wahid3Faridah Hanun Othman4Mohd. Shahrir Mohamed Said5Bintulu Hospital, 97000 Bintulu, Sarawak, MalaysiaUniversiti Kebangsaan Malaysia, MalaysiaMiri Hospital, 98000 Miri, Sarawak, MalaysiaWomen and Child Hospital Sabah, 88996 Kota Kinabalu, Sabah, MalaysiaBalik Pulau Hospital, 11500 Balik Pulau, Penang, MalaysiaDepartment of Internal Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, MalaysiaBackground: Rheumatoid arthritis (RA) is a destructive chronic inflammatory disease with intra- and extra-articular manifestations. It is associated with accelerated formation of arteriosclerosis. The aim of this study was to ascertain the correlation between endothelial dysfunction using carotid intima–media thickness (cIMT) and tumor necrosis factor-alpha (TNF-α) levels among the three main ethnic groups in Malaysia: Malay, Chinese, and Indian. Methods: This cross-sectional study included 23 females with RA belonging to three different ethnic groups who were free from cardiovascular risk factors. Blood sample was taken from each patient to measure serum TNF-α level, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Carotid ultrasonography was performed for cIMT analysis. The Disease Activity Score (DAS)-28 scoring system was used to assess disease activity. Results: Patients’ median age and disease duration were 47 and 5 years, respectively. No thickened cIMT was found in any of the patients. The duration of disease, TNF-α level, cIMT, DAS-28 CRP, and DAS-28 ESR showed no significant correlations in the different ethnic groups (p > 0.05). Conclusion: This study indicates that cIMT and serum TNF-α levels among females with RA in Malaysia may not be affected by ethnicity.https://scholarhub.ui.ac.id/mjhr/vol23/iss3/9/carotid intima–media thicknessethnic groupsrheumatoid arthritistumor necrosis factor-alpha |
| spellingShingle | Kek Xin Yi Asrul A. Wahab Mohamad Norazrin Mohd Abas Siti Amira Kamarul Abdul Wahid Faridah Hanun Othman Mohd. Shahrir Mohamed Said Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia Makara Journal of Health Research carotid intima–media thickness ethnic groups rheumatoid arthritis tumor necrosis factor-alpha |
| title | Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia |
| title_full | Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia |
| title_fullStr | Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia |
| title_full_unstemmed | Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia |
| title_short | Correlation between carotid intima-media thickness and serum TNF-alpha levels in female with rheumatoid arthritis of different ethnicities: A single-centre experience in Malaysia |
| title_sort | correlation between carotid intima media thickness and serum tnf alpha levels in female with rheumatoid arthritis of different ethnicities a single centre experience in malaysia |
| topic | carotid intima–media thickness ethnic groups rheumatoid arthritis tumor necrosis factor-alpha |
| url | https://scholarhub.ui.ac.id/mjhr/vol23/iss3/9/ |
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