Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells[S]

Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells[S]

Recent studies suggest that 7-dehydrocholesterol (7-DHC)-derived oxysterols play important roles in the pathophysiology of Smith-Lemli-Opitz syndrome (SLOS), a metabolic disorder that is caused by defective 3β-hydroxysterol-Δ7-reductase (DHCR7). Although 14 oxysterols have been identified as the pri...

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Bibliographic Details
Main Authors: Libin Xu, Zeljka Korade, Dale A. Rosado, Jr., Karoly Mirnics, Ned A. Porter
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Journal of Lipid Research
Subjects:
Smith-Lemli-Opitz syndrome
lipid peroxidation autoxidation
Neuro2a
fibroblast
mass spectrometry
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422163

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