Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor

Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor

Toxin producing Clostridioides difficile strains cause gastrointestinal infections with the large glucosylating protein toxins A (TcdA) and B (TcdB) being major virulence factors responsible for the onset of symptoms. TcdA and TcdB enter their target cells via receptor-mediated endocytosis. Inside t...

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Bibliographic Details
Main Authors: Dennis Schöttelndreier, Anna Langejürgen, Robert Lindner, Harald Genth
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
clostridial glycosylating toxins
endocytosis
receptors
cell surface
clostridioides difficile infection
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2020.565465/full

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