Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings
Background: Pancreatic cancer (PC) exhibits extremely rapid growth; however, it remains largely unknown whether the early stages of PC also exhibit rapid growth speed equivalent to advanced PC. This study aimed to investigate the natural history of early PCs through retrospectively assessing pre-dia...
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/10/1858 |
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| author | Kentaro Yamao Masakatsu Tsurusaki Kota Takashima Hidekazu Tanaka Akihiro Yoshida Ayana Okamoto Tomohiro Yamazaki Shunsuke Omoto Ken Kamata Kosuke Minaga Mamoru Takenaka Takaaki Chikugo Yasutaka Chiba Tomohiro Watanabe Masatoshi Kudo |
| author_facet | Kentaro Yamao Masakatsu Tsurusaki Kota Takashima Hidekazu Tanaka Akihiro Yoshida Ayana Okamoto Tomohiro Yamazaki Shunsuke Omoto Ken Kamata Kosuke Minaga Mamoru Takenaka Takaaki Chikugo Yasutaka Chiba Tomohiro Watanabe Masatoshi Kudo |
| author_sort | Kentaro Yamao |
| collection | DOAJ |
| description | Background: Pancreatic cancer (PC) exhibits extremely rapid growth; however, it remains largely unknown whether the early stages of PC also exhibit rapid growth speed equivalent to advanced PC. This study aimed to investigate the natural history of early PCs through retrospectively assessing pre-diagnostic images. Methods: We examined the data of nine patients, including three patients with carcinoma in situ (CIS), who had undergone magnetic resonance cholangiopancreatography (MRCP) to detect solitary main pancreatic duct (MPD) stenosis >1 year before definitive PC diagnosis. We retrospectively analyzed the time to diagnosis and first-time tumor detection from the estimated time point of first-time MPD stenosis detection without tumor lesion. Results: The median tumor size at diagnosis and the first-time tumor detection size were 14 and 7.5 mm, respectively. The median time to diagnosis and first-time tumor detection were 26 and 49 months, respectively. Conclusions: No studies have investigated the PC history, especially that of early PCs, including CIS, based on the initial detection of MPD stenosis using MRCP. Assessment of a small number of patients showed that the time to progression can take several years in the early PC stages. Understanding this natural history is very important in the clinical setting. |
| first_indexed | 2024-03-10T06:38:06Z |
| format | Article |
| id | doaj.art-f1fefb51f27b47e7a2b4e6c56376e318 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T06:38:06Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f1fefb51f27b47e7a2b4e6c56376e3182023-11-22T17:57:51ZengMDPI AGDiagnostics2075-44182021-10-011110185810.3390/diagnostics11101858Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography FindingsKentaro Yamao0Masakatsu Tsurusaki1Kota Takashima2Hidekazu Tanaka3Akihiro Yoshida4Ayana Okamoto5Tomohiro Yamazaki6Shunsuke Omoto7Ken Kamata8Kosuke Minaga9Mamoru Takenaka10Takaaki Chikugo11Yasutaka Chiba12Tomohiro Watanabe13Masatoshi Kudo14Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Diagnostic Radiology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Pathology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanClinical Research Center, Kindai University Hospital, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanDepartment of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, JapanBackground: Pancreatic cancer (PC) exhibits extremely rapid growth; however, it remains largely unknown whether the early stages of PC also exhibit rapid growth speed equivalent to advanced PC. This study aimed to investigate the natural history of early PCs through retrospectively assessing pre-diagnostic images. Methods: We examined the data of nine patients, including three patients with carcinoma in situ (CIS), who had undergone magnetic resonance cholangiopancreatography (MRCP) to detect solitary main pancreatic duct (MPD) stenosis >1 year before definitive PC diagnosis. We retrospectively analyzed the time to diagnosis and first-time tumor detection from the estimated time point of first-time MPD stenosis detection without tumor lesion. Results: The median tumor size at diagnosis and the first-time tumor detection size were 14 and 7.5 mm, respectively. The median time to diagnosis and first-time tumor detection were 26 and 49 months, respectively. Conclusions: No studies have investigated the PC history, especially that of early PCs, including CIS, based on the initial detection of MPD stenosis using MRCP. Assessment of a small number of patients showed that the time to progression can take several years in the early PC stages. Understanding this natural history is very important in the clinical setting.https://www.mdpi.com/2075-4418/11/10/1858carcinoma in situcomputed tomographyearly diagnosismagnetic resonance cholangiopancreatographynatural historypancreatic carcinoma |
| spellingShingle | Kentaro Yamao Masakatsu Tsurusaki Kota Takashima Hidekazu Tanaka Akihiro Yoshida Ayana Okamoto Tomohiro Yamazaki Shunsuke Omoto Ken Kamata Kosuke Minaga Mamoru Takenaka Takaaki Chikugo Yasutaka Chiba Tomohiro Watanabe Masatoshi Kudo Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings Diagnostics carcinoma in situ computed tomography early diagnosis magnetic resonance cholangiopancreatography natural history pancreatic carcinoma |
| title | Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings |
| title_full | Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings |
| title_fullStr | Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings |
| title_full_unstemmed | Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings |
| title_short | Analysis of Progression Time in Pancreatic Cancer including Carcinoma In Situ Based on Magnetic Resonance Cholangiopancreatography Findings |
| title_sort | analysis of progression time in pancreatic cancer including carcinoma in situ based on magnetic resonance cholangiopancreatography findings |
| topic | carcinoma in situ computed tomography early diagnosis magnetic resonance cholangiopancreatography natural history pancreatic carcinoma |
| url | https://www.mdpi.com/2075-4418/11/10/1858 |
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