The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats
Abstract Various pharmacological effects including anti-inflammatory and anti-oxidant properties were shown for woody endocarpium of walnut alcoholic extract (WEW). In the study, the effect of the WEW extract in acetic acid induced ulcerative colitis in rats was evaluated. Thiol, glutathione peroxid...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universidade de São Paulo
2022-06-01
|
| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100587&lng=en&tlng=en |
| _version_ | 1818543088114597888 |
|---|---|
| author | Zakieh Keshavarzi Aleme Ashekar Mehran Vatanchian Alireza Abbaspour Bahram Bibak Morteza Behnamfar Saeid Barzegar Farzaneh Shakeri |
| author_facet | Zakieh Keshavarzi Aleme Ashekar Mehran Vatanchian Alireza Abbaspour Bahram Bibak Morteza Behnamfar Saeid Barzegar Farzaneh Shakeri |
| author_sort | Zakieh Keshavarzi |
| collection | DOAJ |
| description | Abstract Various pharmacological effects including anti-inflammatory and anti-oxidant properties were shown for woody endocarpium of walnut alcoholic extract (WEW). In the study, the effect of the WEW extract in acetic acid induced ulcerative colitis in rats was evaluated. Thiol, glutathione peroxidase (GPX), malondialdehyde (MDA), superoxide dismutase (SOD) and gastric acid levels and pathological changes in the colon were investigated in the control group (C), ulcerative colitis group (UC), UC groups treated with WEW extract (10, 20, and 50 mg/kg) and sulfasalazine. Levels of gastric acid, MDA and pathological scores in colon were increased but SOD, GPX and thiol levels were decreased in UC animals compared to those of the control group (p<0.001). Treatment with the highest concentration of extract significantly improved level of thiol and pathological scores compared to the UC group (p<0.05 to p<0.001). Treatment with the two higher concentrations of extract also significantly decreased acid level compared to the UC group (p<0.01 to p<0.001). There was significant improvement in MDA due to treatment with the all concentrations of the extract (p<0.001). Sulfasalazine treatment also significantly improved most parameters compared to the UC group but did not changed pathological scores (p<0.05 to p<0.001). These results indicated a possible preventive therapeutic effect for the WEW extract on UC. |
| first_indexed | 2024-12-11T22:30:43Z |
| format | Article |
| id | doaj.art-f200acc4309e4ffe93f556c8a6587707 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-11T22:30:43Z |
| publishDate | 2022-06-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f200acc4309e4ffe93f556c8a65877072022-12-22T00:48:09ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902022-06-015810.1590/s2175-97902022e19520The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in ratsZakieh KeshavarziAleme AshekarMehran VatanchianAlireza AbbaspourBahram BibakMorteza BehnamfarSaeid BarzegarFarzaneh Shakerihttps://orcid.org/0000-0003-4813-6030Abstract Various pharmacological effects including anti-inflammatory and anti-oxidant properties were shown for woody endocarpium of walnut alcoholic extract (WEW). In the study, the effect of the WEW extract in acetic acid induced ulcerative colitis in rats was evaluated. Thiol, glutathione peroxidase (GPX), malondialdehyde (MDA), superoxide dismutase (SOD) and gastric acid levels and pathological changes in the colon were investigated in the control group (C), ulcerative colitis group (UC), UC groups treated with WEW extract (10, 20, and 50 mg/kg) and sulfasalazine. Levels of gastric acid, MDA and pathological scores in colon were increased but SOD, GPX and thiol levels were decreased in UC animals compared to those of the control group (p<0.001). Treatment with the highest concentration of extract significantly improved level of thiol and pathological scores compared to the UC group (p<0.05 to p<0.001). Treatment with the two higher concentrations of extract also significantly decreased acid level compared to the UC group (p<0.01 to p<0.001). There was significant improvement in MDA due to treatment with the all concentrations of the extract (p<0.001). Sulfasalazine treatment also significantly improved most parameters compared to the UC group but did not changed pathological scores (p<0.05 to p<0.001). These results indicated a possible preventive therapeutic effect for the WEW extract on UC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100587&lng=en&tlng=enWEWOxidative stressGastric acidInflammationUlcerative colitis |
| spellingShingle | Zakieh Keshavarzi Aleme Ashekar Mehran Vatanchian Alireza Abbaspour Bahram Bibak Morteza Behnamfar Saeid Barzegar Farzaneh Shakeri The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats Brazilian Journal of Pharmaceutical Sciences WEW Oxidative stress Gastric acid Inflammation Ulcerative colitis |
| title | The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats |
| title_full | The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats |
| title_fullStr | The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats |
| title_full_unstemmed | The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats |
| title_short | The effect of woody endocarpium of walnut alcoholic extract on acetic acid-induced ulcerative colitis in rats |
| title_sort | effect of woody endocarpium of walnut alcoholic extract on acetic acid induced ulcerative colitis in rats |
| topic | WEW Oxidative stress Gastric acid Inflammation Ulcerative colitis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100587&lng=en&tlng=en |
| work_keys_str_mv | AT zakiehkeshavarzi theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT alemeashekar theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT mehranvatanchian theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT alirezaabbaspour theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT bahrambibak theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT mortezabehnamfar theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT saeidbarzegar theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT farzanehshakeri theeffectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT zakiehkeshavarzi effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT alemeashekar effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT mehranvatanchian effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT alirezaabbaspour effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT bahrambibak effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT mortezabehnamfar effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT saeidbarzegar effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats AT farzanehshakeri effectofwoodyendocarpiumofwalnutalcoholicextractonaceticacidinducedulcerativecolitisinrats |