Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi
Tooth eruption is a complex process that involves osteoclasts to form the eruption pathway. Lipopolysaccharide (LPS) is a bacterial component that plays multifunctional roles in the inflammatory reactions, and one of these roles is powerful stimulation of bone resorption. Osteopontin (OPN) i a phosp...
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| Format: | Article |
| Language: | English |
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Faculty of Dentistry, Universitas Indonesia
2015-10-01
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| Series: | Journal of Dentistry Indonesia |
| Subjects: | |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/783 |
| _version_ | 1818038377429073920 |
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| author | Didin Erma Indahyani Al-Supartinah Santoso Totok Utoro Marsetyawan H. N. E. Soesatyo |
| author_facet | Didin Erma Indahyani Al-Supartinah Santoso Totok Utoro Marsetyawan H. N. E. Soesatyo |
| author_sort | Didin Erma Indahyani |
| collection | DOAJ |
| description | Tooth eruption is a complex process that involves osteoclasts to form the eruption pathway. Lipopolysaccharide (LPS) is a bacterial component that plays multifunctional roles in the inflammatory reactions, and one of these roles is powerful stimulation of bone resorption. Osteopontin (OPN) i a phosphorylated glycoprotein the expression of which is associated with migration, attachment and signaling of osteoclast. The objective of this study was to investigate the effect of LPS on rat alveolaris bone osteopontin during the period of tooth eruption. Fifty five Wistar male albino rats, five days of age were divided into three groups. The first group was not subjected to any treatment. The second group was inducted with LPS at five days of age. The third group was inducted with LPS at nine days of age. Expression of OPN was analysed by immunohistochemical (IHC) approach. The results showed significant differences in OPN expression (p<0.05) within the treated subjects. It was concluded that LPS induction during tooth eruption increases the level of alveolar bone osteopontin. |
| first_indexed | 2024-12-10T07:41:46Z |
| format | Article |
| id | doaj.art-f201c662fcbc47ed8ec499793bfa4e39 |
| institution | Directory Open Access Journal |
| issn | 1693-9697 2355-4800 |
| language | English |
| last_indexed | 2024-12-10T07:41:46Z |
| publishDate | 2015-10-01 |
| publisher | Faculty of Dentistry, Universitas Indonesia |
| record_format | Article |
| series | Journal of Dentistry Indonesia |
| spelling | doaj.art-f201c662fcbc47ed8ec499793bfa4e392022-12-22T01:57:18ZengFaculty of Dentistry, Universitas IndonesiaJournal of Dentistry Indonesia1693-96972355-48002015-10-011412710.14693/jdi.v14i1.783678Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi GigiDidin Erma Indahyani0Al-Supartinah Santoso1Totok Utoro2Marsetyawan H. N. E. Soesatyo3Department of Oral Biology, Faculty of Dentistry, Universitas JemberDepartment of Pediatric Dentistry, Faculty of Dentistry, Universitas Gadjah Mada, YogyakartaDepartment of Anatomic Pathology, Universitas Gadjah Mada, YogyakartaDepartment of Histology, Faculty of Medicine, Universitas Gadjah Mada, YogyakartaTooth eruption is a complex process that involves osteoclasts to form the eruption pathway. Lipopolysaccharide (LPS) is a bacterial component that plays multifunctional roles in the inflammatory reactions, and one of these roles is powerful stimulation of bone resorption. Osteopontin (OPN) i a phosphorylated glycoprotein the expression of which is associated with migration, attachment and signaling of osteoclast. The objective of this study was to investigate the effect of LPS on rat alveolaris bone osteopontin during the period of tooth eruption. Fifty five Wistar male albino rats, five days of age were divided into three groups. The first group was not subjected to any treatment. The second group was inducted with LPS at five days of age. The third group was inducted with LPS at nine days of age. Expression of OPN was analysed by immunohistochemical (IHC) approach. The results showed significant differences in OPN expression (p<0.05) within the treated subjects. It was concluded that LPS induction during tooth eruption increases the level of alveolar bone osteopontin.http://jdentistry.ui.ac.id/index.php/JDI/article/view/783tooth eruptionlipopolysaccharideosteoclastosteopontin |
| spellingShingle | Didin Erma Indahyani Al-Supartinah Santoso Totok Utoro Marsetyawan H. N. E. Soesatyo Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi Journal of Dentistry Indonesia tooth eruption lipopolysaccharide osteoclast osteopontin |
| title | Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi |
| title_full | Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi |
| title_fullStr | Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi |
| title_full_unstemmed | Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi |
| title_short | Pengaruh Induksi Lipopolisakarida (LPS) terhadap Osteopontin Tulang Alveolaris Tikus pada Masa Erupsi Gigi |
| title_sort | pengaruh induksi lipopolisakarida lps terhadap osteopontin tulang alveolaris tikus pada masa erupsi gigi |
| topic | tooth eruption lipopolysaccharide osteoclast osteopontin |
| url | http://jdentistry.ui.ac.id/index.php/JDI/article/view/783 |
| work_keys_str_mv | AT didinermaindahyani pengaruhinduksilipopolisakaridalpsterhadaposteopontintulangalveolaristikuspadamasaerupsigigi AT alsupartinahsantoso pengaruhinduksilipopolisakaridalpsterhadaposteopontintulangalveolaristikuspadamasaerupsigigi AT totokutoro pengaruhinduksilipopolisakaridalpsterhadaposteopontintulangalveolaristikuspadamasaerupsigigi AT marsetyawanhnesoesatyo pengaruhinduksilipopolisakaridalpsterhadaposteopontintulangalveolaristikuspadamasaerupsigigi |