The mechanism underlying transient weakness in myotonia congenita

The mechanism underlying transient weakness in myotonia congenita

In addition to the hallmark muscle stiffness, patients with recessive myotonia congenita (Becker disease) experience debilitating bouts of transient weakness that remain poorly understood despite years of study. We performed intracellular recordings from muscle of both genetic and pharmacologic mous...

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Detalles Bibliográficos
Main Authors: Jessica H Myers, Kirsten Denman, Chris DuPont, Ahmed A Hawash, Kevin R Novak, Andrew Koesters, Manfred Grabner, Anamika Dayal, Andrew A Voss, Mark M Rich
Formato: Artigo
Idioma:English
Publicado: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
muscle fiber
myotonia
sodium channel
calcium channel
persistent sodium current
excitability
Acceso en liña:https://elifesciences.org/articles/65691

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