Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens
ABSTRACT: This study evaluated growth performance and cross-protection against Eimeria spp. using a subunit coccidia vaccine in 2 independent challenge experiments. In both trials, chickens were challenged with E. acervulina, E. maxima, and E. tenella oocysts. In Exp 1, 1000-day-old chickens were al...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579121003631 |
| _version_ | 1818572052189151232 |
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| author | Emanuel Gumina Jeffrey W. Hall Bruno Vecchi Xochitl Hernandez-Velasco Brett Lumpkins Greg Mathis Sherry Layton |
| author_facet | Emanuel Gumina Jeffrey W. Hall Bruno Vecchi Xochitl Hernandez-Velasco Brett Lumpkins Greg Mathis Sherry Layton |
| author_sort | Emanuel Gumina |
| collection | DOAJ |
| description | ABSTRACT: This study evaluated growth performance and cross-protection against Eimeria spp. using a subunit coccidia vaccine in 2 independent challenge experiments. In both trials, chickens were challenged with E. acervulina, E. maxima, and E. tenella oocysts. In Exp 1, 1000-day-old chickens were allocated in one of 2 treatments 1) Control group; 2) Biotech Vac Cox group. The vaccine was orally gavaged on d 2 and 16 of life and coccidia challenge was on d 21. Performance parameters were evaluated on d 21, 35, and 42. On d 34, coccidia lesions were scored. Oocysts per gram of feces (OPG) were evaluated on d 28, 35, and 42. In Exp 2, 900-day-old chickens were assigned in one of 2 treatments 1) Control group; 2) Biotech Vac Cox group. The vaccine was orally gavaged on d 2 and 16 of life and coccidia challenge was on d 21. Performance parameters were evaluated on d 21, 27, 35, and 42, and lesion scores and OPG at d 27. In Exp 1, chickens vaccinated had significantly lower feed intake (FI) at d 21 and feed conversion ratio (FCR) at d 35 compared to control chickens (P < 0.05). Vaccinated chickens showed a significant reduction (P ≤ 0.05) in OPG for E. maxima to nondetectable levels and for all coccidian species at d 42 compared to control chickens. In Exp 2, the chickens vaccinated showed a significant increase in BW, BW gain (BWG) and reduction in FCR on d 27, 35, and 42 (P ≤ 0.05). Vaccinated chickens had significantly lower (P ≤ 0.05) lesion scores for all 3 Eimeria species. Moreover, vaccinated chickens had a reduction in total OPG of 35.50% (P = 0.0739). Studies to evaluate the serological and mucosal immune response are currently being evaluated. This inactivated, orally delivered subunit vaccine offers significant cross-protection to Eimeria spp. and eliminates the needs to treat broilers with live oocysts, enhanced ease of use, and greater biosecurity to producers. |
| first_indexed | 2024-12-14T18:52:16Z |
| format | Article |
| id | doaj.art-f204f6163f8d4c52886c74f1a282dd03 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-12-14T18:52:16Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
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| series | Poultry Science |
| spelling | doaj.art-f204f6163f8d4c52886c74f1a282dd032022-12-21T22:51:13ZengElsevierPoultry Science0032-57912021-09-011009101329Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickensEmanuel Gumina0Jeffrey W. Hall1Bruno Vecchi2Xochitl Hernandez-Velasco3Brett Lumpkins4Greg Mathis5Sherry Layton6Vetanco SA, Villa Martelli B1603, Province of Buenos Aires, ArgentinaVetanco USA, Saint Paul, MN 55114, USAVetanco SA, Villa Martelli B1603, Province of Buenos Aires, ArgentinaDepartment of Avian Medicine and Zootechnics, FMVZ, National Autonomous University of Mexico, Mexico City 04510, MexicoSouthern Poultry Research, Athens, GA 30607, USASouthern Poultry Research, Athens, GA 30607, USAVetanco SA, Villa Martelli B1603, Province of Buenos Aires, Argentina; Vetanco USA, Saint Paul, MN 55114, USA; BV Science, Lenexa, KS 66219, USA; Corresponding author:ABSTRACT: This study evaluated growth performance and cross-protection against Eimeria spp. using a subunit coccidia vaccine in 2 independent challenge experiments. In both trials, chickens were challenged with E. acervulina, E. maxima, and E. tenella oocysts. In Exp 1, 1000-day-old chickens were allocated in one of 2 treatments 1) Control group; 2) Biotech Vac Cox group. The vaccine was orally gavaged on d 2 and 16 of life and coccidia challenge was on d 21. Performance parameters were evaluated on d 21, 35, and 42. On d 34, coccidia lesions were scored. Oocysts per gram of feces (OPG) were evaluated on d 28, 35, and 42. In Exp 2, 900-day-old chickens were assigned in one of 2 treatments 1) Control group; 2) Biotech Vac Cox group. The vaccine was orally gavaged on d 2 and 16 of life and coccidia challenge was on d 21. Performance parameters were evaluated on d 21, 27, 35, and 42, and lesion scores and OPG at d 27. In Exp 1, chickens vaccinated had significantly lower feed intake (FI) at d 21 and feed conversion ratio (FCR) at d 35 compared to control chickens (P < 0.05). Vaccinated chickens showed a significant reduction (P ≤ 0.05) in OPG for E. maxima to nondetectable levels and for all coccidian species at d 42 compared to control chickens. In Exp 2, the chickens vaccinated showed a significant increase in BW, BW gain (BWG) and reduction in FCR on d 27, 35, and 42 (P ≤ 0.05). Vaccinated chickens had significantly lower (P ≤ 0.05) lesion scores for all 3 Eimeria species. Moreover, vaccinated chickens had a reduction in total OPG of 35.50% (P = 0.0739). Studies to evaluate the serological and mucosal immune response are currently being evaluated. This inactivated, orally delivered subunit vaccine offers significant cross-protection to Eimeria spp. and eliminates the needs to treat broilers with live oocysts, enhanced ease of use, and greater biosecurity to producers.http://www.sciencedirect.com/science/article/pii/S0032579121003631apicomplexabroilercoccidiosisEimeriasubunit vaccine |
| spellingShingle | Emanuel Gumina Jeffrey W. Hall Bruno Vecchi Xochitl Hernandez-Velasco Brett Lumpkins Greg Mathis Sherry Layton Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens Poultry Science apicomplexa broiler coccidiosis Eimeria subunit vaccine |
| title | Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens |
| title_full | Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens |
| title_fullStr | Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens |
| title_full_unstemmed | Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens |
| title_short | Evaluation of a subunit vaccine candidate (Biotech Vac Cox) against Eimeria spp. in broiler chickens |
| title_sort | evaluation of a subunit vaccine candidate biotech vac cox against eimeria spp in broiler chickens |
| topic | apicomplexa broiler coccidiosis Eimeria subunit vaccine |
| url | http://www.sciencedirect.com/science/article/pii/S0032579121003631 |
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