Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy
Abstract Ultrasound‐based brain stimulation techniques may become a powerful new technique to modulate the human brain in a focal and targeted manner. However, for clinical brain stimulation no certified systems exist and the current techniques have to be further developed. Here, a clinical sonicati...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-02-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.201902583 |
| _version_ | 1818311559690059776 |
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| author | Roland Beisteiner Eva Matt Christina Fan Heike Baldysiak Marleen Schönfeld Tabea Philippi Novak Ahmad Amini Tuna Aslan Raphael Reinecke Johann Lehrner Alexandra Weber Ulrike Reime Cédric Goldenstedt Ernst Marlinghaus Mark Hallett Henning Lohse‐Busch |
| author_facet | Roland Beisteiner Eva Matt Christina Fan Heike Baldysiak Marleen Schönfeld Tabea Philippi Novak Ahmad Amini Tuna Aslan Raphael Reinecke Johann Lehrner Alexandra Weber Ulrike Reime Cédric Goldenstedt Ernst Marlinghaus Mark Hallett Henning Lohse‐Busch |
| author_sort | Roland Beisteiner |
| collection | DOAJ |
| description | Abstract Ultrasound‐based brain stimulation techniques may become a powerful new technique to modulate the human brain in a focal and targeted manner. However, for clinical brain stimulation no certified systems exist and the current techniques have to be further developed. Here, a clinical sonication technique is introduced, based on single ultrashort ultrasound pulses (transcranial pulse stimulation, TPS) which markedly differs from existing focused ultrasound techniques. In addition, a first clinical study using ultrasound brain stimulation and first observations of long term effects are presented. Comprehensive feasibility, safety, and efficacy data are provided. They consist of simulation data, laboratory measurements with rat and human skulls and brains, in vivo modulations of somatosensory evoked potentials (SEP) in healthy subjects (sham controlled) and clinical pilot data in 35 patients with Alzheimer's disease acquired in a multicenter setting (including neuropsychological scores and functional magnetic resonance imaging (fMRI)). Preclinical results show large safety margins and dose dependent neuromodulation. Patient investigations reveal high treatment tolerability and no major side effects. Neuropsychological scores improve significantly after TPS treatment and improvement lasts up to three months and correlates with an upregulation of the memory network (fMRI data). The results encourage broad neuroscientific application and translation of the method to clinical therapy and randomized sham‐controlled clinical studies. |
| first_indexed | 2024-12-13T08:03:53Z |
| format | Article |
| id | doaj.art-f2056a9056894b4d8aca8a94f415c799 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-13T08:03:53Z |
| publishDate | 2020-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-f2056a9056894b4d8aca8a94f415c7992022-12-21T23:54:22ZengWileyAdvanced Science2198-38442020-02-0173n/an/a10.1002/advs.201902583Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain TherapyRoland Beisteiner0Eva Matt1Christina Fan2Heike Baldysiak3Marleen Schönfeld4Tabea Philippi Novak5Ahmad Amini6Tuna Aslan7Raphael Reinecke8Johann Lehrner9Alexandra Weber10Ulrike Reime11Cédric Goldenstedt12Ernst Marlinghaus13Mark Hallett14Henning Lohse‐Busch15Department of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaApplied Research Center Storz Medical AG Lohstampfestrasse 8 Tägerwilen 8274 SwitzerlandRheintalklinik Outpatient Department Manual Medicine Center for Movement Disorders Thürachstraße 10 Bad Krozingen 79189 GermanyDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaDepartment of Neurology Laboratory for Functional Brain Diagnostics and Therapy High Field MR Center Medical University of Vienna Spitalgasse 23 Vienna 1090 AustriaRheintalklinik Outpatient Department Manual Medicine Center for Movement Disorders Thürachstraße 10 Bad Krozingen 79189 GermanyApplied Research Center Storz Medical AG Lohstampfestrasse 8 Tägerwilen 8274 SwitzerlandApplied Research Center Storz Medical AG Lohstampfestrasse 8 Tägerwilen 8274 SwitzerlandHuman Motor Control Section NINDS NIH 10 Center Drive Bethesda MD 20892‐1428 USARheintalklinik Outpatient Department Manual Medicine Center for Movement Disorders Thürachstraße 10 Bad Krozingen 79189 GermanyAbstract Ultrasound‐based brain stimulation techniques may become a powerful new technique to modulate the human brain in a focal and targeted manner. However, for clinical brain stimulation no certified systems exist and the current techniques have to be further developed. Here, a clinical sonication technique is introduced, based on single ultrashort ultrasound pulses (transcranial pulse stimulation, TPS) which markedly differs from existing focused ultrasound techniques. In addition, a first clinical study using ultrasound brain stimulation and first observations of long term effects are presented. Comprehensive feasibility, safety, and efficacy data are provided. They consist of simulation data, laboratory measurements with rat and human skulls and brains, in vivo modulations of somatosensory evoked potentials (SEP) in healthy subjects (sham controlled) and clinical pilot data in 35 patients with Alzheimer's disease acquired in a multicenter setting (including neuropsychological scores and functional magnetic resonance imaging (fMRI)). Preclinical results show large safety margins and dose dependent neuromodulation. Patient investigations reveal high treatment tolerability and no major side effects. Neuropsychological scores improve significantly after TPS treatment and improvement lasts up to three months and correlates with an upregulation of the memory network (fMRI data). The results encourage broad neuroscientific application and translation of the method to clinical therapy and randomized sham‐controlled clinical studies.https://doi.org/10.1002/advs.201902583Alzheimer's diseasebrain stimulationultrasound |
| spellingShingle | Roland Beisteiner Eva Matt Christina Fan Heike Baldysiak Marleen Schönfeld Tabea Philippi Novak Ahmad Amini Tuna Aslan Raphael Reinecke Johann Lehrner Alexandra Weber Ulrike Reime Cédric Goldenstedt Ernst Marlinghaus Mark Hallett Henning Lohse‐Busch Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy Advanced Science Alzheimer's disease brain stimulation ultrasound |
| title | Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy |
| title_full | Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy |
| title_fullStr | Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy |
| title_full_unstemmed | Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy |
| title_short | Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease—A New Navigated Focal Brain Therapy |
| title_sort | transcranial pulse stimulation with ultrasound in alzheimer s disease a new navigated focal brain therapy |
| topic | Alzheimer's disease brain stimulation ultrasound |
| url | https://doi.org/10.1002/advs.201902583 |
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