KSHV ORF57, a Protein of Many Faces

KSHV ORF57, a Protein of Many Faces

Kaposi’s sarcoma-associated herpesvirus (KSHV) ORF57 protein (also known as mRNA transcript accumulation (Mta)) is a potent posttranscriptional regulator essential for the efficient expression of KSHV lytic genes and productive KSHV replication. ORF57 possesses numerous activities that promote the e...

Full description

Bibliographic Details
Main Authors:	Vladimir Majerciak, Zhi-Ming Zheng
Format:	Article
Language:	English
Published:	MDPI AG 2015-02-01
Series:	Viruses
Subjects:	KSHV ORF57 protein viral expression posttranscriptional regulator RNA processing
Online Access:	http://www.mdpi.com/1999-4915/7/2/604

Similar Items

Multiple Regions of Kaposi’s Sarcoma-Associated Herpesvirus ORF59 RNA are Required for Its Expression Mediated by Viral ORF57 and Cellular RBM15
by: Maria Julia Massimelli, et al.
Published: (2015-02-01)

KSHV ORF59 and PAN RNA Recruit Histone Demethylases to the Viral Chromatin during Lytic Reactivation
by: Kayla Hiura, et al.
Published: (2020-04-01)

Targeting Kaposi’s sarcoma associated herpesvirus encoded protease (ORF17) by a lysophosphatidic acid molecule for treating KSHV associated diseases
by: Misbahuddin M Rafeeq, et al.
Published: (2023-01-01)

Disruption of the Interaction between ORF33 and the Conserved Carboxyl-Terminus of ORF45 Abolishes Progeny Virion Production of Kaposi Sarcoma-Associated Herpesvirus
by: Joseph Gillen, et al.
Published: (2021-09-01)

RNA Granules in Antiviral Innate Immunity: A Kaposi’s Sarcoma-Associated Herpesvirus Journey
by: Nishi R. Sharma, et al.
Published: (2022-01-01)

The Kaposi’s Sarcoma-Associated Herpesvirus Protein ORF42 Is Required for Efficient Virion Production and Expression of Viral Proteins
by: Matthew Butnaru, et al.
Published: (2019-08-01)

Treatment of Kaposi sarcoma-associated herpesvirus (KSHV)-associated cancers
by: Dirk P Dittmer, et al.
Published: (2012-04-01)

KSHV Reprogramming of Host Energy Metabolism for Pathogenesis
by: Xiaoqing Liu, et al.
Published: (2021-05-01)

Twenty Years of KSHV
by: Yuan Chang, et al.
Published: (2014-11-01)

The ORF45 Protein of Kaposi’s Sarcoma-Associated Herpesvirus and Its Critical Role in the Viral Life Cycle
by: Natalie Atyeo, et al.
Published: (2022-09-01)

Novel <it>C16orf57 </it>mutations in patients with Poikiloderma with Neutropenia: bioinformatic analysis of the protein and predicted effects of all reported mutations
by: Colombo Elisa A, et al.
Published: (2012-01-01)

Chromatinization of the KSHV Genome During the KSHV Life Cycle
by: Timsy Uppal, et al.
Published: (2015-01-01)

Stealing the Show: KSHV Hijacks Host RNA Regulatory Pathways to Promote Infection
by: Daniel Macveigh-Fierro, et al.
Published: (2020-09-01)

Clericuzio-type Poikiloderma with Neutropenia Syndrome in a Turkish Family: a Three Report of Siblings with Mutation in the C16orf57 gene
by: Turkan Patiroglu, et al.
Published: (2015-10-01)

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis
by: Mara Cirone
Published: (2018-10-01)

KSHV inhibits stress granule formation by viral ORF57 blocking PKR activation.
by: Nishi R Sharma, et al.
Published: (2017-10-01)

Genome-wide regulation of KSHV RNA splicing by viral RNA-binding protein ORF57.
by: Vladimir Majerciak, et al.
Published: (2022-07-01)

Co-infections and Pathogenesis of KSHV-Associated Malignancies
by: Suhani eThakker, et al.
Published: (2016-02-01)

Regulation of KSHV Latency and Lytic Reactivation
by: Grant Broussard, et al.
Published: (2020-09-01)

The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers
by: Ashley Markazi, et al.
Published: (2021-08-01)

Suppression of DC-SIGN and gH Reveals Complex, Subset-Specific Mechanisms for KSHV Entry in Primary B Lymphocytes
by: Nancy Palmerin, et al.
Published: (2021-07-01)

SUMO and KSHV Replication
by: Pei-Ching Chang, et al.
Published: (2014-09-01)

Kaposi’s Sarcoma-Associated Herpesvirus ORF50 Protein Represses Cellular MDM2 Expression via Suppressing the Sp1- and p53-Mediated Transactivation
by: Chia-I Lin, et al.
Published: (2022-08-01)

KSHV miRNAs Decrease Expression of Lytic Genes in Latently Infected PEL and Endothelial Cells by Targeting Host Transcription Factors
by: Karlie Plaisance-Bonstaff, et al.
Published: (2014-10-01)

Posttranscriptional Regulation by Copper with a New Upstream Open Reading Frame
by: Gauthier Roy, et al.
Published: (2022-08-01)

Glycosylation of KSHV Encoded vGPCR Functions in Its Signaling and Tumorigenicity
by: Hui Wu, et al.
Published: (2015-03-01)

KSHV genome replication and maintenance
by: Pravinkumar ePurushothaman, et al.
Published: (2016-02-01)

A Toolbox for Herpesvirus miRNA Research: Construction of a Complete Set of KSHV miRNA Deletion Mutants
by: Vaibhav Jain, et al.
Published: (2016-02-01)

Variation in KSHV prevalence between geographically proximate locations in Uganda
by: Angela Nalwoga, et al.
Published: (2020-07-01)

KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia
by: Dipayan Bose, et al.
Published: (2024-01-01)

The crystal structure of KSHV ORF57 reveals dimeric active sites important for protein stability and function.
by: Fei Yuan, et al.
Published: (2018-08-01)

Loss of orf3b in the circulating SARS-CoV-2 strains
by: Joy-Yan Lam, et al.
Published: (2020-01-01)

Clinical Significance of Elevated KSHV Viral Load in HIV-Related Kaposi’s Sarcoma Patients in South Africa
by: Rebecca Monica Tibenderana, et al.
Published: (2024-01-01)

KSHV: Immune Modulation and Immunotherapy
by: Grant Broussard, et al.
Published: (2020-02-01)

Kaposi's sarcoma associated herpesvirus (KSHV) entry into target cells
by: Sayan eChakraborty, et al.
Published: (2012-01-01)

A major role for Nrf2 transcription factors in cell transformation by KSHV encoded oncogenes
by: Daiana Sapochnik, et al.
Published: (2022-09-01)

IL-21 signaling promotes the establishment of KSHV infection in human tonsil lymphocytes by increasing differentiation and targeting of plasma cells
by: Nedaa Alomari, et al.
Published: (2022-12-01)

The Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) gH/gL Complex Is the Predominant Neutralizing Antigenic Determinant in KSHV-Infected Individuals
by: Yasaman Mortazavi, et al.
Published: (2020-02-01)

The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?
by: Blossom eDamania, et al.
Published: (2011-06-01)

The Portal Vertex of KSHV Promotes Docking of Capsids at the Nuclear Pores
by: Daniela Dünn-Kittenplon, et al.
Published: (2021-03-01)