A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement
We report a case of bloodstream infection due to Ruminococcus gnavus (R. gnavus) associated with pelvic abscess in a 74-year-old female patient undergoing radiotherapy for cervical cancer. Gram staining of positive anaerobic blood cultures revealed short chains of gram-positive cocci. Matrix-assiste...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023032188 |
| _version_ | 1827937420276924416 |
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| author | Tomoki Furutani Hiroyuki Kitano Kenichiro Ikeda Satoshi Shirane Yumiko Koba Seiya Kashiyama Hiroki Kitagawa Kohei kobatake Keisuke Hieda Hiroki Ohge Nobuyuki Hinata |
| author_facet | Tomoki Furutani Hiroyuki Kitano Kenichiro Ikeda Satoshi Shirane Yumiko Koba Seiya Kashiyama Hiroki Kitagawa Kohei kobatake Keisuke Hieda Hiroki Ohge Nobuyuki Hinata |
| author_sort | Tomoki Furutani |
| collection | DOAJ |
| description | We report a case of bloodstream infection due to Ruminococcus gnavus (R. gnavus) associated with pelvic abscess in a 74-year-old female patient undergoing radiotherapy for cervical cancer. Gram staining of positive anaerobic blood cultures revealed short chains of gram-positive cocci. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry was performed directly on the blood culture bottle, and 16S rRNA sequencing identified the bacterium as R. gnavus. There was no leakage from the sigmoid colon to rectum on enterography, and R. gnavus was not found in the culture of her pelvic abscess. After the administration of piperacillin/tazobactam, her condition markedly improved. This patient with R. gnavus infection demonstrated no gastrointestinal involvement, whereas past published cases reported diverticulitis or intestinal damage. It is possible that bacterial translocation of R. gnavus occurred from the gut microbiota, due to damage to the intestinal tract caused by radiation. |
| first_indexed | 2024-03-13T08:25:22Z |
| format | Article |
| id | doaj.art-f20ad56968644c84b2ad6b5f5dd0047a |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T08:25:22Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f20ad56968644c84b2ad6b5f5dd0047a2023-05-31T04:46:18ZengElsevierHeliyon2405-84402023-05-0195e16011A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvementTomoki Furutani0Hiroyuki Kitano1Kenichiro Ikeda2Satoshi Shirane3Yumiko Koba4Seiya Kashiyama5Hiroki Kitagawa6 Kohei kobatake7Keisuke Hieda8Hiroki Ohge9Nobuyuki Hinata10Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, JapanDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Japan; Corresponding author. Department of Urology, Hiroshima University. 734-8551, Kasumi 1-2-3 Minamiku Hiroshima City, Hiroshima, Japan.Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, JapanDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, JapanDepartment of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima City, JapanDepartment of Clinical Practice and Support, Hiroshima University Hospital, Hiroshima City, JapanDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima City, JapanDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, JapanDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, JapanDepartment of Infectious Diseases, Hiroshima University Hospital, Hiroshima City, JapanDepartment of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, JapanWe report a case of bloodstream infection due to Ruminococcus gnavus (R. gnavus) associated with pelvic abscess in a 74-year-old female patient undergoing radiotherapy for cervical cancer. Gram staining of positive anaerobic blood cultures revealed short chains of gram-positive cocci. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry was performed directly on the blood culture bottle, and 16S rRNA sequencing identified the bacterium as R. gnavus. There was no leakage from the sigmoid colon to rectum on enterography, and R. gnavus was not found in the culture of her pelvic abscess. After the administration of piperacillin/tazobactam, her condition markedly improved. This patient with R. gnavus infection demonstrated no gastrointestinal involvement, whereas past published cases reported diverticulitis or intestinal damage. It is possible that bacterial translocation of R. gnavus occurred from the gut microbiota, due to damage to the intestinal tract caused by radiation.http://www.sciencedirect.com/science/article/pii/S2405844023032188Ruminococcus gnavusBloodstream infectionPiperacillin/tazobactamGastrointestinal involvement |
| spellingShingle | Tomoki Furutani Hiroyuki Kitano Kenichiro Ikeda Satoshi Shirane Yumiko Koba Seiya Kashiyama Hiroki Kitagawa Kohei kobatake Keisuke Hieda Hiroki Ohge Nobuyuki Hinata A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement Heliyon Ruminococcus gnavus Bloodstream infection Piperacillin/tazobactam Gastrointestinal involvement |
| title | A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement |
| title_full | A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement |
| title_fullStr | A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement |
| title_full_unstemmed | A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement |
| title_short | A case of bloodstream infection caused by Ruminococcus gnavus without gastrointestinal involvement |
| title_sort | case of bloodstream infection caused by ruminococcus gnavus without gastrointestinal involvement |
| topic | Ruminococcus gnavus Bloodstream infection Piperacillin/tazobactam Gastrointestinal involvement |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023032188 |
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