Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice
In the past 40 years, scientific research has shown how Whole Body Vibration concept represents a strong stimulus for the whole organism. Low (<30 Hz), medium (30–80 Hz), and high (>80 Hz) frequency vibrations can have both positive and negative effects, depending on the oscillation type and d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/1/82 |
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| author | Ida Cariati Roberto Bonanni Gabriele Pallone Giuseppe Annino Virginia Tancredi Giovanna D’Arcangelo |
| author_facet | Ida Cariati Roberto Bonanni Gabriele Pallone Giuseppe Annino Virginia Tancredi Giovanna D’Arcangelo |
| author_sort | Ida Cariati |
| collection | DOAJ |
| description | In the past 40 years, scientific research has shown how Whole Body Vibration concept represents a strong stimulus for the whole organism. Low (<30 Hz), medium (30–80 Hz), and high (>80 Hz) frequency vibrations can have both positive and negative effects, depending on the oscillation type and duration of exposure to which the body is subjected. However, very little is known about the effects of vibratory training on the brain. In this regard, we verified whether three vibratory training protocols, differing in terms of vibration frequency and exposure time to vibration, could modulate synaptic plasticity in an experimental mouse model, by extracellular recordings in vitro in hippocampal slices of mice of 4 and 24 months old. Our results showed that vibratory training can modulate synaptic plasticity differently, depending on the protocol used, and that the best effects are related to the training protocol characterized by a low vibration frequency and a longer recovery time. Future studies will aim to understand the brain responses to various types of vibratory training and to explore the underlying mechanisms, also evaluating the presence of any structural and functional changes due to vibratory training. |
| first_indexed | 2024-03-09T05:22:43Z |
| format | Article |
| id | doaj.art-f20aec9243c345858cd51b47116d1ade |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T05:22:43Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f20aec9243c345858cd51b47116d1ade2023-12-03T12:39:34ZengMDPI AGBrain Sciences2076-34252021-01-011118210.3390/brainsci11010082Modulation of Synaptic Plasticity by Vibratory Training in Young and Old MiceIda Cariati0Roberto Bonanni1Gabriele Pallone2Giuseppe Annino3Virginia Tancredi4Giovanna D’Arcangelo5Department of Clinical Sciences and Translational Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyDepartment of Systems Medicine, “Tor Vergata” University of Rome, Via Montpellier 1, 00133 Rome, ItalyIn the past 40 years, scientific research has shown how Whole Body Vibration concept represents a strong stimulus for the whole organism. Low (<30 Hz), medium (30–80 Hz), and high (>80 Hz) frequency vibrations can have both positive and negative effects, depending on the oscillation type and duration of exposure to which the body is subjected. However, very little is known about the effects of vibratory training on the brain. In this regard, we verified whether three vibratory training protocols, differing in terms of vibration frequency and exposure time to vibration, could modulate synaptic plasticity in an experimental mouse model, by extracellular recordings in vitro in hippocampal slices of mice of 4 and 24 months old. Our results showed that vibratory training can modulate synaptic plasticity differently, depending on the protocol used, and that the best effects are related to the training protocol characterized by a low vibration frequency and a longer recovery time. Future studies will aim to understand the brain responses to various types of vibratory training and to explore the underlying mechanisms, also evaluating the presence of any structural and functional changes due to vibratory training.https://www.mdpi.com/2076-3425/11/1/82vibratory trainingsynaptic plasticityhippocampusagingwhole body vibration |
| spellingShingle | Ida Cariati Roberto Bonanni Gabriele Pallone Giuseppe Annino Virginia Tancredi Giovanna D’Arcangelo Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice Brain Sciences vibratory training synaptic plasticity hippocampus aging whole body vibration |
| title | Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice |
| title_full | Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice |
| title_fullStr | Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice |
| title_full_unstemmed | Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice |
| title_short | Modulation of Synaptic Plasticity by Vibratory Training in Young and Old Mice |
| title_sort | modulation of synaptic plasticity by vibratory training in young and old mice |
| topic | vibratory training synaptic plasticity hippocampus aging whole body vibration |
| url | https://www.mdpi.com/2076-3425/11/1/82 |
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