Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study
Abstract Background and Aims Although SARS‐CoV‐2 infection usually leads to mild COVID‐19 in children, sometimes it causes serious complications, especially in those with underlying diseases. Several factors have been identified in determining disease severity in adults, and limited studies have bee...
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1259 |
| _version_ | 1797816766096736256 |
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| author | Marzieh Jamalidoust Seyedeh Sedigheh Hamzavi Eslam Shorafa Mandana Namayandeh Laiba Batool Seyedeh Narges Abootalebi |
| author_facet | Marzieh Jamalidoust Seyedeh Sedigheh Hamzavi Eslam Shorafa Mandana Namayandeh Laiba Batool Seyedeh Narges Abootalebi |
| author_sort | Marzieh Jamalidoust |
| collection | DOAJ |
| description | Abstract Background and Aims Although SARS‐CoV‐2 infection usually leads to mild COVID‐19 in children, sometimes it causes serious complications, especially in those with underlying diseases. Several factors have been identified in determining disease severity in adults, and limited studies have been conducted in children. The prognostic implications of SARS‐CoV‐2 RNaemia as an important factor in determining disease severity in children are not well understood. Methods In this study, we aimed to prospectively assess the relationship between disease severity and immunological factors and viremia in 47 COVID‐19 hospitalized children. In this research, 76.5% of children experienced mild and moderate COVID‐19, while 23.5% experienced severe and critical forms of the disease. Results The presence of underlying diseases in different groups of pediatric patients differed significantly from each other. On the other hand, clinical symptoms such as vomiting and chest pain as well as laboratory parameters including erythrocyte sedimentation rate were significantly different in different groups of patients. Viremia was seen in only two children, and this had no significant relationship with the severity of COVID‐19. Conclusion In conclusion, our data confirmed that COVID‐19 severity differed in SARS‐CoV‐2 infected children. Some clinical presentation and lab data parameters were different in various presentation of patients. Viremia was not associated with severity in our study. |
| first_indexed | 2024-03-13T08:42:34Z |
| format | Article |
| id | doaj.art-f20ba2d9a0be475eb6fb849d066d6af5 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-03-13T08:42:34Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-f20ba2d9a0be475eb6fb849d066d6af52023-05-30T08:58:34ZengWileyHealth Science Reports2398-88352023-05-0165n/an/a10.1002/hsr2.1259Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional studyMarzieh Jamalidoust0Seyedeh Sedigheh Hamzavi1Eslam Shorafa2Mandana Namayandeh3Laiba Batool4Seyedeh Narges Abootalebi5Department of Virology, Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital Shiraz University of Medical Sciences Shiraz IranProfessor Alborzi Clinical Microbiology Research Center Namazi Hospital, Shiraz University of Medical Sciences Shiraz IranPediatric Intensivist, Intensive Care Unit division, Department of Pediatrics, School of Medicine Shiraz University of Medical Sciences Shiraz IranDepartment of Virology, Professor Alborzi Clinical Microbiology Research Center, Namazi Hospital Shiraz University of Medical Sciences Shiraz IranSchool of Medicine Shiraz University of Medical Sciences Shiraz IranPediatric Intensivist, Intensive Care Unit division, Department of Pediatrics, School of Medicine Shiraz University of Medical Sciences Shiraz IranAbstract Background and Aims Although SARS‐CoV‐2 infection usually leads to mild COVID‐19 in children, sometimes it causes serious complications, especially in those with underlying diseases. Several factors have been identified in determining disease severity in adults, and limited studies have been conducted in children. The prognostic implications of SARS‐CoV‐2 RNaemia as an important factor in determining disease severity in children are not well understood. Methods In this study, we aimed to prospectively assess the relationship between disease severity and immunological factors and viremia in 47 COVID‐19 hospitalized children. In this research, 76.5% of children experienced mild and moderate COVID‐19, while 23.5% experienced severe and critical forms of the disease. Results The presence of underlying diseases in different groups of pediatric patients differed significantly from each other. On the other hand, clinical symptoms such as vomiting and chest pain as well as laboratory parameters including erythrocyte sedimentation rate were significantly different in different groups of patients. Viremia was seen in only two children, and this had no significant relationship with the severity of COVID‐19. Conclusion In conclusion, our data confirmed that COVID‐19 severity differed in SARS‐CoV‐2 infected children. Some clinical presentation and lab data parameters were different in various presentation of patients. Viremia was not associated with severity in our study.https://doi.org/10.1002/hsr2.1259COVID‐19paraclinical datapediatricsSARS‐CoV‐2severityviremia |
| spellingShingle | Marzieh Jamalidoust Seyedeh Sedigheh Hamzavi Eslam Shorafa Mandana Namayandeh Laiba Batool Seyedeh Narges Abootalebi Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study Health Science Reports COVID‐19 paraclinical data pediatrics SARS‐CoV‐2 severity viremia |
| title | Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study |
| title_full | Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study |
| title_fullStr | Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study |
| title_full_unstemmed | Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study |
| title_short | Comparing clinical presentation, viremia, and immunological factors at various severity presentations in hospitalized children affected by COVID‐19: A cross‐sectional study |
| title_sort | comparing clinical presentation viremia and immunological factors at various severity presentations in hospitalized children affected by covid 19 a cross sectional study |
| topic | COVID‐19 paraclinical data pediatrics SARS‐CoV‐2 severity viremia |
| url | https://doi.org/10.1002/hsr2.1259 |
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