Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study
Abstract Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53929-w |
| _version_ | 1827327679192367104 |
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| author | Julie Delanote Alejandro Correa Rojo Philippa M. Wells Claire J. Steves Gökhan Ertaylan |
| author_facet | Julie Delanote Alejandro Correa Rojo Philippa M. Wells Claire J. Steves Gökhan Ertaylan |
| author_sort | Julie Delanote |
| collection | DOAJ |
| description | Abstract Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and eating disorders remain poorly understood. Currently, there are no robust biomarkers identified. We proposed a novel pyramid-layer design to accurately identify microbial/metabolomic signatures underlying mental disorders in the TwinsUK registry. Monozygotic and dizygotic twins discordant for mental disorders were screened, in a pairwise manner, for differentially abundant bacterial genera and circulating metabolites. In addition, multivariate analyses were performed, accounting for individual-level confounders. Our pyramid-layer study design allowed us to overcome the limitations of cross-sectional study designs with significant confounder effects and resulted in an association of the abundance of genus Parabacteroides with the diagnosis of mental disorders. Future research should explore the potential role of Parabacteroides as a mediator of mental health status. Our results indicate the potential role of the microbiome as a modifier in mental disorders that might contribute to the development of novel methodologies to assess personal risk and intervention strategies. |
| first_indexed | 2024-03-07T15:04:50Z |
| format | Article |
| id | doaj.art-f20c420c764d4503845219b02d457337 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:04:50Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f20c420c764d4503845219b02d4573372024-03-05T18:59:05ZengNature PortfolioScientific Reports2045-23222024-02-0114111610.1038/s41598-024-53929-wSystematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort studyJulie Delanote0Alejandro Correa Rojo1Philippa M. Wells2Claire J. Steves3Gökhan Ertaylan4Sustainable Health, Flemish Institute for Technological Research (VITO)Sustainable Health, Flemish Institute for Technological Research (VITO)Department of Twin Research and Genetic Epidemiology, King’s College London, St Thomas’ HospitalDepartment of Twin Research and Genetic Epidemiology, King’s College London, St Thomas’ HospitalSustainable Health, Flemish Institute for Technological Research (VITO)Abstract Mental disorders are complex disorders influenced by multiple genetic, environmental, and biological factors. Specific microbiota imbalances seem to affect mental health status. However, the mechanisms by which microbiota disturbances impact the presence of depression, stress, anxiety, and eating disorders remain poorly understood. Currently, there are no robust biomarkers identified. We proposed a novel pyramid-layer design to accurately identify microbial/metabolomic signatures underlying mental disorders in the TwinsUK registry. Monozygotic and dizygotic twins discordant for mental disorders were screened, in a pairwise manner, for differentially abundant bacterial genera and circulating metabolites. In addition, multivariate analyses were performed, accounting for individual-level confounders. Our pyramid-layer study design allowed us to overcome the limitations of cross-sectional study designs with significant confounder effects and resulted in an association of the abundance of genus Parabacteroides with the diagnosis of mental disorders. Future research should explore the potential role of Parabacteroides as a mediator of mental health status. Our results indicate the potential role of the microbiome as a modifier in mental disorders that might contribute to the development of novel methodologies to assess personal risk and intervention strategies.https://doi.org/10.1038/s41598-024-53929-w |
| spellingShingle | Julie Delanote Alejandro Correa Rojo Philippa M. Wells Claire J. Steves Gökhan Ertaylan Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study Scientific Reports |
| title | Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study |
| title_full | Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study |
| title_fullStr | Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study |
| title_full_unstemmed | Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study |
| title_short | Systematic identification of the role of gut microbiota in mental disorders: a TwinsUK cohort study |
| title_sort | systematic identification of the role of gut microbiota in mental disorders a twinsuk cohort study |
| url | https://doi.org/10.1038/s41598-024-53929-w |
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