Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody

Dose escalation PET imaging for safety and effective therapy dose optimization of a bispecific antibody

Selecting the dose for efficacy and first-in-human studies of bispecific antibodies (BsAbs) is a challenging process. Herein, positron emission tomography (PET) imaging with 89Zr-labeled IBI322, an anti-CD47/PD-L1 BsAb, was used to optimize the safety and effective therapy dose. By labeling with 89Z...

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Bibliographic Details
Main Authors: Yan Wang, Donghui Pan, Chenrong Huang, Bingliang Chen, Mingzhu Li, Shuaixiang Zhou, Lizhen Wang, Min Wu, Xinyu Wang, Yicong Bian, Junjie Yan, Junjian Liu, Min Yang, Liyan Miao
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:mAbs
Subjects:
89zr-immunoPET
bispecific antibodies
target engagement
dose selection
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2020.1748322

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