Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy
Introduction: Women with epilepsy (WWE) have an increased risk for several endocrine disorders. Obesity and Polycystic Ovarian Syndrome (PCOS) are common side-effects of anticonvulsant drugs. Aim: To study the prevalence of Obesity, PCOS, Thyroid dysfunction in WWE on monotherapy with Carbamazepine...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2012-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2012;volume=15;issue=2;spage=101;epage=105;aulast=Ayyagari |
| _version_ | 1818194478639349760 |
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| author | Mythili Ayyagari Sita Ramu Chitela Venkateswarlu Kolachana |
| author_facet | Mythili Ayyagari Sita Ramu Chitela Venkateswarlu Kolachana |
| author_sort | Mythili Ayyagari |
| collection | DOAJ |
| description | Introduction: Women with epilepsy (WWE) have an increased risk for several endocrine disorders. Obesity and Polycystic Ovarian Syndrome (PCOS) are common side-effects of anticonvulsant drugs. Aim: To study the prevalence of Obesity, PCOS, Thyroid dysfunction in WWE on monotherapy with Carbamazepine (CBZ), Sodium Valproate (VAL) and Phenytoin (DPH) Material and Methods: Sixty WWE in the reproductive age group (13 - 45 yr) who are on atleast 6 months of monotherapy with either CBZ (20) or VAL (20) or DPH (20) are subjects of the study. Their Anthropometric data is recorded. They are interviewed and investigated for PCOS and thyroid dysfunction. Twenty healthy women in the reproductive age group served as controls. BMI>25 is taken as cut-off for Obesity. PCOS is defined as menstrual irregularity and/or clinical /biochemical hyperandrogenism with ultrasound evidence of PCO as per the Rotterdam criteria. TSH <0.1 and >4 is taken as evidence of thyroid dysfunction. Women are grouped according to the anticonvulsant drug received and the data analyzed in each group. Results: The mean BMI among VAL and CBZ users is significantly higher than among DPH users (23.3 & 23.4 vs 20.4). There is no significant difference in incidence of PCOS among WWE using either DPH or VAL or CBZ. Elevated TSH>4 is seen more often in WWE on VAL (9/20) compared to CBZ (6/20) and DPH (3/20). WWE on CBZ, VAL and DPH did not differ in mean BMI, Obesity, PCOS compared to healthy controls. As compared to healthy controls, more WWE on drug therapy had significantly elevated TSH (1/20 vs20/60). Conclusions: WWE on VAL and CBZ had significant weight gain compared to DPH users. Despite weight gain, there was no difference in the incidence of PCOS between the users of VAL, CBZ and DPH. As compared to healthy controls, more WWE on drug therapy had significantly elevated TSH, more so in the VAL group. |
| first_indexed | 2024-12-12T01:02:56Z |
| format | Article |
| id | doaj.art-f20eb8a1ed554746936cc8a7f9c1db88 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-12-12T01:02:56Z |
| publishDate | 2012-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-f20eb8a1ed554746936cc8a7f9c1db882022-12-22T00:43:40ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492012-01-0115210110510.4103/0972-2327.94992Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsyMythili AyyagariSita Ramu ChitelaVenkateswarlu KolachanaIntroduction: Women with epilepsy (WWE) have an increased risk for several endocrine disorders. Obesity and Polycystic Ovarian Syndrome (PCOS) are common side-effects of anticonvulsant drugs. Aim: To study the prevalence of Obesity, PCOS, Thyroid dysfunction in WWE on monotherapy with Carbamazepine (CBZ), Sodium Valproate (VAL) and Phenytoin (DPH) Material and Methods: Sixty WWE in the reproductive age group (13 - 45 yr) who are on atleast 6 months of monotherapy with either CBZ (20) or VAL (20) or DPH (20) are subjects of the study. Their Anthropometric data is recorded. They are interviewed and investigated for PCOS and thyroid dysfunction. Twenty healthy women in the reproductive age group served as controls. BMI>25 is taken as cut-off for Obesity. PCOS is defined as menstrual irregularity and/or clinical /biochemical hyperandrogenism with ultrasound evidence of PCO as per the Rotterdam criteria. TSH <0.1 and >4 is taken as evidence of thyroid dysfunction. Women are grouped according to the anticonvulsant drug received and the data analyzed in each group. Results: The mean BMI among VAL and CBZ users is significantly higher than among DPH users (23.3 & 23.4 vs 20.4). There is no significant difference in incidence of PCOS among WWE using either DPH or VAL or CBZ. Elevated TSH>4 is seen more often in WWE on VAL (9/20) compared to CBZ (6/20) and DPH (3/20). WWE on CBZ, VAL and DPH did not differ in mean BMI, Obesity, PCOS compared to healthy controls. As compared to healthy controls, more WWE on drug therapy had significantly elevated TSH (1/20 vs20/60). Conclusions: WWE on VAL and CBZ had significant weight gain compared to DPH users. Despite weight gain, there was no difference in the incidence of PCOS between the users of VAL, CBZ and DPH. As compared to healthy controls, more WWE on drug therapy had significantly elevated TSH, more so in the VAL group.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2012;volume=15;issue=2;spage=101;epage=105;aulast=AyyagariBody mass indexpolycystic ovarian syndromephenytoinsodium valproatecarbamazepinethyroid stimulating hormonewomen with epilepsy |
| spellingShingle | Mythili Ayyagari Sita Ramu Chitela Venkateswarlu Kolachana Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy Annals of Indian Academy of Neurology Body mass index polycystic ovarian syndrome phenytoin sodium valproate carbamazepine thyroid stimulating hormone women with epilepsy |
| title | Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy |
| title_full | Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy |
| title_fullStr | Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy |
| title_full_unstemmed | Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy |
| title_short | Obesity, polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy |
| title_sort | obesity polycystic ovarian syndrome and thyroid dysfunction in women with epilepsy |
| topic | Body mass index polycystic ovarian syndrome phenytoin sodium valproate carbamazepine thyroid stimulating hormone women with epilepsy |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2012;volume=15;issue=2;spage=101;epage=105;aulast=Ayyagari |
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