Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation
Safflower extract is commonly used as a traditional Chinese medicine to promote blood circulation and remove blood stasis. The antioxidant and anticancer properties of safflower extracts have been extensively studied, but their antiaggregative effects have been less analyzed. We found that safflower...
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| Format: | Article |
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MDPI AG
2021-06-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/10/6/1192 |
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| author | Ping-Hsun Lu Chan-Yen Kuo Chuan-Chi Chan Lu-Kai Wang Mao-Liang Chen I-Shiang Tzeng Fu-Ming Tsai |
| author_facet | Ping-Hsun Lu Chan-Yen Kuo Chuan-Chi Chan Lu-Kai Wang Mao-Liang Chen I-Shiang Tzeng Fu-Ming Tsai |
| author_sort | Ping-Hsun Lu |
| collection | DOAJ |
| description | Safflower extract is commonly used as a traditional Chinese medicine to promote blood circulation and remove blood stasis. The antioxidant and anticancer properties of safflower extracts have been extensively studied, but their antiaggregative effects have been less analyzed. We found that safflower extract inhibited human platelet aggregation induced by ADP. In addition, we further analyzed several safflower extract compounds, such as hydroxysafflor yellow A, safflower yellow A, and luteolin, which have the same antiaggregative effect. In addition to analyzing the active components of the safflower extract, we also analyzed their roles in the ADP signaling pathways. Safflower extract can affect the activation of downstream conductors of ADP receptors (such as the production of calcium ions and cAMP), thereby affecting the expression of activated glycoproteins on the platelet membrane and inhibiting platelet aggregation. According to the results of this study, the effect of safflower extract on promoting blood circulation and removing blood stasis may be related to its direct inhibition of platelet activation. |
| first_indexed | 2024-03-10T10:30:48Z |
| format | Article |
| id | doaj.art-f210a82f037c439284526a288731bc61 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T10:30:48Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-f210a82f037c439284526a288731bc612023-11-21T23:44:03ZengMDPI AGPlants2223-77472021-06-01106119210.3390/plants10061192Safflower Extract Inhibits ADP-Induced Human Platelet AggregationPing-Hsun Lu0Chan-Yen Kuo1Chuan-Chi Chan2Lu-Kai Wang3Mao-Liang Chen4I-Shiang Tzeng5Fu-Ming Tsai6Department of Chinese Medicine, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Laboratory Medicine, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanRadiation Biology Core Laboratory, Institute for Radiological Research, Chang Gung University/Chang Gung Memorial Hospital, Linkou, Taoyuan 333, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanDepartment of Research, Taipei Tzu Chi Hospital, The Buddhist Tzu Chi Medical Foundation, New Taipei City 231, TaiwanSafflower extract is commonly used as a traditional Chinese medicine to promote blood circulation and remove blood stasis. The antioxidant and anticancer properties of safflower extracts have been extensively studied, but their antiaggregative effects have been less analyzed. We found that safflower extract inhibited human platelet aggregation induced by ADP. In addition, we further analyzed several safflower extract compounds, such as hydroxysafflor yellow A, safflower yellow A, and luteolin, which have the same antiaggregative effect. In addition to analyzing the active components of the safflower extract, we also analyzed their roles in the ADP signaling pathways. Safflower extract can affect the activation of downstream conductors of ADP receptors (such as the production of calcium ions and cAMP), thereby affecting the expression of activated glycoproteins on the platelet membrane and inhibiting platelet aggregation. According to the results of this study, the effect of safflower extract on promoting blood circulation and removing blood stasis may be related to its direct inhibition of platelet activation.https://www.mdpi.com/2223-7747/10/6/1192safflowerhydroxysafflor yellow Asafflower yellow Aflavonoidplatelet aggregation |
| spellingShingle | Ping-Hsun Lu Chan-Yen Kuo Chuan-Chi Chan Lu-Kai Wang Mao-Liang Chen I-Shiang Tzeng Fu-Ming Tsai Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation Plants safflower hydroxysafflor yellow A safflower yellow A flavonoid platelet aggregation |
| title | Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation |
| title_full | Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation |
| title_fullStr | Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation |
| title_full_unstemmed | Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation |
| title_short | Safflower Extract Inhibits ADP-Induced Human Platelet Aggregation |
| title_sort | safflower extract inhibits adp induced human platelet aggregation |
| topic | safflower hydroxysafflor yellow A safflower yellow A flavonoid platelet aggregation |
| url | https://www.mdpi.com/2223-7747/10/6/1192 |
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