Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword
Reactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their mult...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.784612/full |
| _version_ | 1818750808424972288 |
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| author | Jie Wang Jie Wang Ning Liu Hongfei Jiang Hongfei Jiang Qian Li Dongming Xing Dongming Xing Dongming Xing |
| author_facet | Jie Wang Jie Wang Ning Liu Hongfei Jiang Hongfei Jiang Qian Li Dongming Xing Dongming Xing Dongming Xing |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | Reactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their multiple roles, which may vary with their concentration, location and the immune microenvironment they are in. Here, we have reviewed the reported effects of ROS on macrophage polarization, immune checkpoint blocking (ICB) therapy, T cell activation and expansion, as well as the induction of immunogenic cell death. A majority of reports are indicating detrimental effects of ROS, but it is unadvisable to simply scavenge them because of their pleiotropic effects in most occasions (except in T cell activation and expansion where ROS are generally undesirable). Therefore, clinical success will need a clearer illustration of their multi-faced functions, as well as more advanced technologies to tune ROS level with high spatiotemporal control and species-specificity. With such progresses, the efficacy of current immunotherapies will be greatly improved by combining with ROS-targeted therapies. |
| first_indexed | 2024-12-18T04:25:33Z |
| format | Article |
| id | doaj.art-f210d43dd16945698f52750385c345af |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-18T04:25:33Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-f210d43dd16945698f52750385c345af2022-12-21T21:21:08ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-11-01910.3389/fbioe.2021.784612784612Reactive Oxygen Species in Anticancer Immunity: A Double-Edged SwordJie Wang0Jie Wang1Ning Liu2Hongfei Jiang3Hongfei Jiang4Qian Li5Dongming Xing6Dongming Xing7Dongming Xing8The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaQingdao Cancer Institute, Qingdao University, Qingdao, ChinaQingdao Cancer Institute, Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaQingdao Cancer Institute, Qingdao University, Qingdao, ChinaQingdao Cancer Institute, Qingdao University, Qingdao, ChinaThe Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, ChinaQingdao Cancer Institute, Qingdao University, Qingdao, ChinaSchool of Life Sciences, Tsinghua University, Beijing, ChinaReactive oxygen species (ROS) are critical mediators in many physiological processes including innate and adaptive immunity, making the modulation of ROS level a powerful strategy to augment anticancer immunity. However, current evidences suggest the necessity of a deeper understanding of their multiple roles, which may vary with their concentration, location and the immune microenvironment they are in. Here, we have reviewed the reported effects of ROS on macrophage polarization, immune checkpoint blocking (ICB) therapy, T cell activation and expansion, as well as the induction of immunogenic cell death. A majority of reports are indicating detrimental effects of ROS, but it is unadvisable to simply scavenge them because of their pleiotropic effects in most occasions (except in T cell activation and expansion where ROS are generally undesirable). Therefore, clinical success will need a clearer illustration of their multi-faced functions, as well as more advanced technologies to tune ROS level with high spatiotemporal control and species-specificity. With such progresses, the efficacy of current immunotherapies will be greatly improved by combining with ROS-targeted therapies.https://www.frontiersin.org/articles/10.3389/fbioe.2021.784612/fullROSimmunotherapymacrophage polarizationT cell activationimmunogenic cell death |
| spellingShingle | Jie Wang Jie Wang Ning Liu Hongfei Jiang Hongfei Jiang Qian Li Dongming Xing Dongming Xing Dongming Xing Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword Frontiers in Bioengineering and Biotechnology ROS immunotherapy macrophage polarization T cell activation immunogenic cell death |
| title | Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword |
| title_full | Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword |
| title_fullStr | Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword |
| title_full_unstemmed | Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword |
| title_short | Reactive Oxygen Species in Anticancer Immunity: A Double-Edged Sword |
| title_sort | reactive oxygen species in anticancer immunity a double edged sword |
| topic | ROS immunotherapy macrophage polarization T cell activation immunogenic cell death |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.784612/full |
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