Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature
Abstract Background Mature cystic teratoma of the ovary is classified among the benign ovarian germ cell neoplasms, and its malignant transformation occurs very rarely (in about 2%). As a result of nonspecific signs and symptoms, preoperative diagnosis of theses malignancies is a challenge to clinic...
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-024-04465-8 |
| _version_ | 1797233565753147392 |
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| author | Amir Masoud Jafari-Nozad Najmeh Jahani Narges Nazeri |
| author_facet | Amir Masoud Jafari-Nozad Najmeh Jahani Narges Nazeri |
| author_sort | Amir Masoud Jafari-Nozad |
| collection | DOAJ |
| description | Abstract Background Mature cystic teratoma of the ovary is classified among the benign ovarian germ cell neoplasms, and its malignant transformation occurs very rarely (in about 2%). As a result of nonspecific signs and symptoms, preoperative diagnosis of theses malignancies is a challenge to clinicians, resulting in delayed diagnosis (in advanced stages) and poor outcomes. Case presentation We report the case of a 43-year-old Iranian woman with progressive distension of the abdomen and hypogastric pain, who was diagnosed with squamous cell carcinoma transformation in a mature cystic teratoma of the ovary confirmed by histopathology examination. Total abdominal hysterectomy, bilateral salpingooophorectomy, and comprehensive staging surgery were performed for the patient, and she was scheduled for chemotherapy after the surgery. She responded well to the treatment and is currently continuing her chemotherapy process. Conclusion There are a great number of reports in the literature regarding mature cystic teratoma of the ovary transformation into malignancy, so these neoplasms must be considered as a possible differential diagnosis and should be evaluated in older individuals with abdominal pain and palpable mass, or those with considerable tumor diameter and raised serum tumor markers. |
| first_indexed | 2024-04-24T16:18:12Z |
| format | Article |
| id | doaj.art-f21151bf869445d6974953e483d3b739 |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-24T16:18:12Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-f21151bf869445d6974953e483d3b7392024-03-31T11:21:57ZengBMCJournal of Medical Case Reports1752-19472024-03-011811810.1186/s13256-024-04465-8Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literatureAmir Masoud Jafari-Nozad0Najmeh Jahani1Narges Nazeri2Student Research Committee, Birjand University of Medical SciencesDepartment of Gynecology, School of Medicine, Valiasr Hospital, Birjand University of Medical SciencesDepartment of Pathology, Faculty of Medicine, Birjand University of Medical SciencesAbstract Background Mature cystic teratoma of the ovary is classified among the benign ovarian germ cell neoplasms, and its malignant transformation occurs very rarely (in about 2%). As a result of nonspecific signs and symptoms, preoperative diagnosis of theses malignancies is a challenge to clinicians, resulting in delayed diagnosis (in advanced stages) and poor outcomes. Case presentation We report the case of a 43-year-old Iranian woman with progressive distension of the abdomen and hypogastric pain, who was diagnosed with squamous cell carcinoma transformation in a mature cystic teratoma of the ovary confirmed by histopathology examination. Total abdominal hysterectomy, bilateral salpingooophorectomy, and comprehensive staging surgery were performed for the patient, and she was scheduled for chemotherapy after the surgery. She responded well to the treatment and is currently continuing her chemotherapy process. Conclusion There are a great number of reports in the literature regarding mature cystic teratoma of the ovary transformation into malignancy, so these neoplasms must be considered as a possible differential diagnosis and should be evaluated in older individuals with abdominal pain and palpable mass, or those with considerable tumor diameter and raised serum tumor markers.https://doi.org/10.1186/s13256-024-04465-8Mature cystic teratomaMalignant transformationOvarian neoplasmSquamous cell carcinoma |
| spellingShingle | Amir Masoud Jafari-Nozad Najmeh Jahani Narges Nazeri Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature Journal of Medical Case Reports Mature cystic teratoma Malignant transformation Ovarian neoplasm Squamous cell carcinoma |
| title | Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature |
| title_full | Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature |
| title_fullStr | Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature |
| title_full_unstemmed | Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature |
| title_short | Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature |
| title_sort | squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary a case report and review of the literature |
| topic | Mature cystic teratoma Malignant transformation Ovarian neoplasm Squamous cell carcinoma |
| url | https://doi.org/10.1186/s13256-024-04465-8 |
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