Potential applications of using tissue-specific EVs in targeted therapy and vaccinology
Many cell types secrete spherical membrane bodies classified as extracellular vesicles (EVs). EVs participate in intercellular communication and are present in body fluids, including blood, lymph, and cerebrospinal fluid. The time of EVs survival in the body varies depending on the body’s localisati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223010995 |
| _version_ | 1797686900686848000 |
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| author | Tomasz P. Lehmann Marta Golik Jolanta Olejnik Marianna Łukaszewska Dominika Markowska Martyna Drożdżyńska Aleksander Kotecki Maciej Głowacki Paweł P. Jagodziński |
| author_facet | Tomasz P. Lehmann Marta Golik Jolanta Olejnik Marianna Łukaszewska Dominika Markowska Martyna Drożdżyńska Aleksander Kotecki Maciej Głowacki Paweł P. Jagodziński |
| author_sort | Tomasz P. Lehmann |
| collection | DOAJ |
| description | Many cell types secrete spherical membrane bodies classified as extracellular vesicles (EVs). EVs participate in intercellular communication and are present in body fluids, including blood, lymph, and cerebrospinal fluid. The time of EVs survival in the body varies depending on the body’s localisation. Once the EVs reach cells, they trigger a cellular response. Three main modes of direct interaction of EVs with a target cell were described: receptor-ligand interaction mode, a direct fusion of EVs with the cellular membrane and EVs internalisation. Studies focused on the medical application of EVs. Medical application of EVs may require modification of their surface and interior. EVs surface was modified by affecting the parental cells or by the direct amendment of isolated EVs. The interior modification involved introducing materials into the cells or direct administrating isolated EVs. EVs carry proteins, lipids, fragments of DNA, mRNA, microRNA (miRNA) and long non-coding RNA. Because of EVs availability in liquid biopsy, they are potential diagnostic markers. Modified EVs could enhance the treatment of diseases such as colorectal cancer, Parkinson’s disease, leukaemia or liver fibrosis. EVs have specific tissue tropisms, which makes them convenient organ-directed carriers of nucleic acids, drugs and vaccines. In conclusion, recently published works have shown that EVs could become biomarkers and modern vehicles of advanced drug forms. |
| first_indexed | 2024-03-12T01:11:16Z |
| format | Article |
| id | doaj.art-f2126535706e44c3b735d41d4724f31e |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-12T01:11:16Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f2126535706e44c3b735d41d4724f31e2023-09-14T04:52:35ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-10-01166115308Potential applications of using tissue-specific EVs in targeted therapy and vaccinologyTomasz P. Lehmann0Marta Golik1Jolanta Olejnik2Marianna Łukaszewska3Dominika Markowska4Martyna Drożdżyńska5Aleksander Kotecki6Maciej Głowacki7Paweł P. Jagodziński8Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, Poland; Correspondence to: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, ul. Swiecickiego 6, 60-781 Poznan, Poland.Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandDepartment of Paediatric Orthopaedics and Traumatology, Poznan University of Medical Sciences, 61-545 Poznan, PolandDepartment of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 60-781 Poznan, PolandMany cell types secrete spherical membrane bodies classified as extracellular vesicles (EVs). EVs participate in intercellular communication and are present in body fluids, including blood, lymph, and cerebrospinal fluid. The time of EVs survival in the body varies depending on the body’s localisation. Once the EVs reach cells, they trigger a cellular response. Three main modes of direct interaction of EVs with a target cell were described: receptor-ligand interaction mode, a direct fusion of EVs with the cellular membrane and EVs internalisation. Studies focused on the medical application of EVs. Medical application of EVs may require modification of their surface and interior. EVs surface was modified by affecting the parental cells or by the direct amendment of isolated EVs. The interior modification involved introducing materials into the cells or direct administrating isolated EVs. EVs carry proteins, lipids, fragments of DNA, mRNA, microRNA (miRNA) and long non-coding RNA. Because of EVs availability in liquid biopsy, they are potential diagnostic markers. Modified EVs could enhance the treatment of diseases such as colorectal cancer, Parkinson’s disease, leukaemia or liver fibrosis. EVs have specific tissue tropisms, which makes them convenient organ-directed carriers of nucleic acids, drugs and vaccines. In conclusion, recently published works have shown that EVs could become biomarkers and modern vehicles of advanced drug forms.http://www.sciencedirect.com/science/article/pii/S0753332223010995MiRNAExtracellular vesiclesExosome-based vaccinesColorectal cancerParkinson’s diseaseLeukaemia |
| spellingShingle | Tomasz P. Lehmann Marta Golik Jolanta Olejnik Marianna Łukaszewska Dominika Markowska Martyna Drożdżyńska Aleksander Kotecki Maciej Głowacki Paweł P. Jagodziński Potential applications of using tissue-specific EVs in targeted therapy and vaccinology Biomedicine & Pharmacotherapy MiRNA Extracellular vesicles Exosome-based vaccines Colorectal cancer Parkinson’s disease Leukaemia |
| title | Potential applications of using tissue-specific EVs in targeted therapy and vaccinology |
| title_full | Potential applications of using tissue-specific EVs in targeted therapy and vaccinology |
| title_fullStr | Potential applications of using tissue-specific EVs in targeted therapy and vaccinology |
| title_full_unstemmed | Potential applications of using tissue-specific EVs in targeted therapy and vaccinology |
| title_short | Potential applications of using tissue-specific EVs in targeted therapy and vaccinology |
| title_sort | potential applications of using tissue specific evs in targeted therapy and vaccinology |
| topic | MiRNA Extracellular vesicles Exosome-based vaccines Colorectal cancer Parkinson’s disease Leukaemia |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223010995 |
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