Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs
<abstract language="eng">The thalidomide disaster, in the 60,s, is the most painful reminder of the importance of chirality for biological activity. After this episode, much attention has been devoted to study the correlations between toxicological and pharmacological properties and...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
1997-12-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000600014 |
| _version_ | 1818009113066471424 |
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| author | Eliezer J. Barreiro Vitor. F. Ferreira Paulo R. R. Costa |
| author_facet | Eliezer J. Barreiro Vitor. F. Ferreira Paulo R. R. Costa |
| author_sort | Eliezer J. Barreiro |
| collection | DOAJ |
| description | <abstract language="eng">The thalidomide disaster, in the 60,s, is the most painful reminder of the importance of chirality for biological activity. After this episode, much attention has been devoted to study the correlations between toxicological and pharmacological properties and chirality. Actualy, to get a licence for a new chiral drug in EUA, European community and Japan, it is necessary to study the biological properties of each enatiomer independently. This article presents an overview about the importance of the chirality of organic compounds and its relationships with biological activity, asymmetric synthetic methodologies and market. |
| first_indexed | 2024-04-14T05:38:01Z |
| format | Article |
| id | doaj.art-f21289ad4f72429db73a983eb7ae1204 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-04-14T05:38:01Z |
| publishDate | 1997-12-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-f21289ad4f72429db73a983eb7ae12042022-12-22T02:09:34ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70641997-12-0120664765610.1590/S0100-40421997000600014Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugsEliezer J. BarreiroVitor. F. FerreiraPaulo R. R. Costa<abstract language="eng">The thalidomide disaster, in the 60,s, is the most painful reminder of the importance of chirality for biological activity. After this episode, much attention has been devoted to study the correlations between toxicological and pharmacological properties and chirality. Actualy, to get a licence for a new chiral drug in EUA, European community and Japan, it is necessary to study the biological properties of each enatiomer independently. This article presents an overview about the importance of the chirality of organic compounds and its relationships with biological activity, asymmetric synthetic methodologies and market.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000600014chiral technologyasymmetric synthesisdrugs chirality |
| spellingShingle | Eliezer J. Barreiro Vitor. F. Ferreira Paulo R. R. Costa Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs Química Nova chiral technology asymmetric synthesis drugs chirality |
| title | Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs |
| title_full | Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs |
| title_fullStr | Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs |
| title_full_unstemmed | Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs |
| title_short | Substâncias enantiomericamente puras (SEP): a questão dos fármacos quirais Pure enantiomeric substances: the question of chiral drugs |
| title_sort | substancias enantiomericamente puras sep a questao dos farmacos quirais pure enantiomeric substances the question of chiral drugs |
| topic | chiral technology asymmetric synthesis drugs chirality |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40421997000600014 |
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