Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study
BackgroundNeuropsychological studies have revealed that patients with schizophrenia (SZ) have facial recognition difficulties and a reduced visual evoked N170 response to human faces. However, detailed neurophysiological evidence of this face processing deficit in SZ with a higher spatial resolution...
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2020.554844/full |
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| author | Naotoshi Ohara Naotoshi Ohara Yoji Hirano Yoji Hirano Naoya Oribe Naoya Oribe Shunsuke Tamura Itta Nakamura Shogo Hirano Rikako Tsuchimoto Rikako Tsuchimoto Takefumi Ueno Takefumi Ueno Osamu Togao Akio Hiwatashi Tomohiro Nakao Toshiaki Onitsuka |
| author_facet | Naotoshi Ohara Naotoshi Ohara Yoji Hirano Yoji Hirano Naoya Oribe Naoya Oribe Shunsuke Tamura Itta Nakamura Shogo Hirano Rikako Tsuchimoto Rikako Tsuchimoto Takefumi Ueno Takefumi Ueno Osamu Togao Akio Hiwatashi Tomohiro Nakao Toshiaki Onitsuka |
| author_sort | Naotoshi Ohara |
| collection | DOAJ |
| description | BackgroundNeuropsychological studies have revealed that patients with schizophrenia (SZ) have facial recognition difficulties and a reduced visual evoked N170 response to human faces. However, detailed neurophysiological evidence of this face processing deficit in SZ with a higher spatial resolution has yet to be acquired. In this study, we recorded visual evoked magnetoencephalography (MEG) and examined whether M170 (a magnetic counterpart of the N170) activity deficits are specific to faces in patients with chronic SZ.MethodsParticipants were 26 patients with SZ and 26 healthy controls (HC). The M170 responses to faces and cars were recorded from whole-head MEG, and global field power over each temporal cortex was analyzed. The distributed M170 sources were also localized using a minimum-norm estimation (MNE) method. Correlational analyses between M170 responses and demographics/symptoms were performed.ResultsAs expected, the M170 was significantly smaller in the SZ compared with the HC group in response to faces, but not to cars (faces: p = 0.01; cars: p = 0.55). The MNE analysis demonstrated that while the M170 was localized over the fusiform face area (FFA) in the HC group, visual-related brain regions other than the FFA were strongly activated in the SZ group in both stimulus conditions. The severity of negative symptoms was negatively correlated with M170 power (rho = −0.47, p = 0.01) in SZ. Within HC, there was a significant correlation between age and the M170 responses to faces averaged for both hemispheres (rho = 0.60, p = 0.001), while such a relationship was not observed in patients with SZ (rho = 0.09, p = 0.67).ConclusionThe present study showed specific reductions in the M170 response to human faces in patients with SZ. Our findings could suggest that SZ is characterized by face processing deficits that are associated with the severity of negative symptoms. Thus, we suggest that social cognition impairments in SZ might, at least in part, be caused by this functional face processing deficit. |
| first_indexed | 2024-12-11T13:57:34Z |
| format | Article |
| id | doaj.art-f21636af75904e3d8b558bbece804e17 |
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| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-11T13:57:34Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-f21636af75904e3d8b558bbece804e172022-12-22T01:04:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-09-011110.3389/fpsyt.2020.554844554844Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG StudyNaotoshi Ohara0Naotoshi Ohara1Yoji Hirano2Yoji Hirano3Naoya Oribe4Naoya Oribe5Shunsuke Tamura6Itta Nakamura7Shogo Hirano8Rikako Tsuchimoto9Rikako Tsuchimoto10Takefumi Ueno11Takefumi Ueno12Osamu Togao13Akio Hiwatashi14Tomohiro Nakao15Toshiaki Onitsuka16Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanMedical Corporation Seiryokai, Mimamigaoka Hospital, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Psychiatry, Harvard Medical School, Boston, MA, United StatesDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDivision of Clinical Research, National Hospital Organization, Hizen Psychiatric Medical Center, Saga, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanCenter for Health Sciences and Counseling, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDivision of Clinical Research, National Hospital Organization, Hizen Psychiatric Medical Center, Saga, JapanDepartment of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanDepartment of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, JapanBackgroundNeuropsychological studies have revealed that patients with schizophrenia (SZ) have facial recognition difficulties and a reduced visual evoked N170 response to human faces. However, detailed neurophysiological evidence of this face processing deficit in SZ with a higher spatial resolution has yet to be acquired. In this study, we recorded visual evoked magnetoencephalography (MEG) and examined whether M170 (a magnetic counterpart of the N170) activity deficits are specific to faces in patients with chronic SZ.MethodsParticipants were 26 patients with SZ and 26 healthy controls (HC). The M170 responses to faces and cars were recorded from whole-head MEG, and global field power over each temporal cortex was analyzed. The distributed M170 sources were also localized using a minimum-norm estimation (MNE) method. Correlational analyses between M170 responses and demographics/symptoms were performed.ResultsAs expected, the M170 was significantly smaller in the SZ compared with the HC group in response to faces, but not to cars (faces: p = 0.01; cars: p = 0.55). The MNE analysis demonstrated that while the M170 was localized over the fusiform face area (FFA) in the HC group, visual-related brain regions other than the FFA were strongly activated in the SZ group in both stimulus conditions. The severity of negative symptoms was negatively correlated with M170 power (rho = −0.47, p = 0.01) in SZ. Within HC, there was a significant correlation between age and the M170 responses to faces averaged for both hemispheres (rho = 0.60, p = 0.001), while such a relationship was not observed in patients with SZ (rho = 0.09, p = 0.67).ConclusionThe present study showed specific reductions in the M170 response to human faces in patients with SZ. Our findings could suggest that SZ is characterized by face processing deficits that are associated with the severity of negative symptoms. Thus, we suggest that social cognition impairments in SZ might, at least in part, be caused by this functional face processing deficit.https://www.frontiersin.org/article/10.3389/fpsyt.2020.554844/fullschizophreniamagnetoencephalographyM170human facesfusiform gyrus |
| spellingShingle | Naotoshi Ohara Naotoshi Ohara Yoji Hirano Yoji Hirano Naoya Oribe Naoya Oribe Shunsuke Tamura Itta Nakamura Shogo Hirano Rikako Tsuchimoto Rikako Tsuchimoto Takefumi Ueno Takefumi Ueno Osamu Togao Akio Hiwatashi Tomohiro Nakao Toshiaki Onitsuka Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study Frontiers in Psychiatry schizophrenia magnetoencephalography M170 human faces fusiform gyrus |
| title | Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study |
| title_full | Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study |
| title_fullStr | Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study |
| title_full_unstemmed | Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study |
| title_short | Neurophysiological Face Processing Deficits in Patients With Chronic Schizophrenia: An MEG Study |
| title_sort | neurophysiological face processing deficits in patients with chronic schizophrenia an meg study |
| topic | schizophrenia magnetoencephalography M170 human faces fusiform gyrus |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2020.554844/full |
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