Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles
Drug release is a critical parameter in the discipline of drug delivery for years. The determination of in vitro release kinetics of active substances from drug systems plays a critical role in predicting and managing of both efficacy and safety. Kinetics is more than a scientific goal; it is a fund...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2020-06-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=67069 |
| _version_ | 1797327732367949824 |
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| author | Sema Arisoy Tansel Comoglu |
| author_facet | Sema Arisoy Tansel Comoglu |
| author_sort | Sema Arisoy |
| collection | DOAJ |
| description | Drug release is a critical parameter in the discipline of drug delivery for years. The determination of in vitro release kinetics of active substances from drug systems plays a critical role in predicting and managing of both efficacy and safety. Kinetics is more than a scientific goal; it is a fundamental quality parameter of all type of drugs. Kinetic models are developed to determine drug release from delivery systems which the released drug amount (Q) is plotted versus time; t or as a function of time Q=f (t). Kinetic models facilitate the understanding of release pattern in enabling to design an effective formulation. In this study wheat germ agglutinin (WGA) conjugated, L-Dopa loaded, poly lactic-co-glycolic acid (PLGA) nanoparticles were analyzed for determining the release pattern of L-Dopa. Higuchi, zero order, first order, Hixon Crowell and Korsmeyer-Peppas models were investigated. Hixson Crowell model was found to be the best fitted kinetic model in L-Dopa loaded nanoparticles (r2 =0.9828). [Med-Science 2020; 9(2.000): 385-8] |
| first_indexed | 2024-03-08T06:42:47Z |
| format | Article |
| id | doaj.art-f2173e43af1f446ab5f986a546657ff0 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:42:47Z |
| publishDate | 2020-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-f2173e43af1f446ab5f986a546657ff02024-02-03T08:37:00ZengSociety of Turaz BilimMedicine Science2147-06342020-06-0192385810.5455/medscience.2019.08.920967069Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticlesSema Arisoy0Tansel ComogluAnkara Universty, Faculty of Pharmacy, Department of Pharmaceutical Technology, Ankara, TurkeyDrug release is a critical parameter in the discipline of drug delivery for years. The determination of in vitro release kinetics of active substances from drug systems plays a critical role in predicting and managing of both efficacy and safety. Kinetics is more than a scientific goal; it is a fundamental quality parameter of all type of drugs. Kinetic models are developed to determine drug release from delivery systems which the released drug amount (Q) is plotted versus time; t or as a function of time Q=f (t). Kinetic models facilitate the understanding of release pattern in enabling to design an effective formulation. In this study wheat germ agglutinin (WGA) conjugated, L-Dopa loaded, poly lactic-co-glycolic acid (PLGA) nanoparticles were analyzed for determining the release pattern of L-Dopa. Higuchi, zero order, first order, Hixon Crowell and Korsmeyer-Peppas models were investigated. Hixson Crowell model was found to be the best fitted kinetic model in L-Dopa loaded nanoparticles (r2 =0.9828). [Med-Science 2020; 9(2.000): 385-8]http://www.ejmanager.com/fulltextpdf.php?mno=67069kinetic evaluationfirst orderzero orderhixon-crowellkorsmeyer-pepashiguchi |
| spellingShingle | Sema Arisoy Tansel Comoglu Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles Medicine Science kinetic evaluation first order zero order hixon-crowell korsmeyer-pepas higuchi |
| title | Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles |
| title_full | Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles |
| title_fullStr | Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles |
| title_full_unstemmed | Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles |
| title_short | Kinetic evaluation of L-Dopa loaded WGA-grafted nanoparticles |
| title_sort | kinetic evaluation of l dopa loaded wga grafted nanoparticles |
| topic | kinetic evaluation first order zero order hixon-crowell korsmeyer-pepas higuchi |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=67069 |
| work_keys_str_mv | AT semaarisoy kineticevaluationofldopaloadedwgagraftednanoparticles AT tanselcomoglu kineticevaluationofldopaloadedwgagraftednanoparticles |