Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study
Abstract Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors of sarcopenia and is associated with the survival of patients with cancer. However, few studies have addressed the association of HGS and 1 year mortality of patients with cancer cachexia. Methods This cohort study inc...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.12778 |
| _version_ | 1797205400336990208 |
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| author | Mengmeng Song Qi Zhang Meng Tang Xi Zhang Guotian Ruan Xiaowei Zhang Kangping Zhang Yizhong Ge Ming Yang Qinqin Li Xiangrui Li Xiaoyue Liu Wei Li Minghua Cong Kunhua Wang Chunhua Song Hanping Shi |
| author_facet | Mengmeng Song Qi Zhang Meng Tang Xi Zhang Guotian Ruan Xiaowei Zhang Kangping Zhang Yizhong Ge Ming Yang Qinqin Li Xiangrui Li Xiaoyue Liu Wei Li Minghua Cong Kunhua Wang Chunhua Song Hanping Shi |
| author_sort | Mengmeng Song |
| collection | DOAJ |
| description | Abstract Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors of sarcopenia and is associated with the survival of patients with cancer. However, few studies have addressed the association of HGS and 1 year mortality of patients with cancer cachexia. Methods This cohort study included 8466 patients with malignant solid tumour from 40 clinical centres throughout China. Cachexia was diagnosed using the 2011 International cancer cachexia consensus. The hazard ratio (HR) of all cancer cachexia mortality was calculated using Cox proportional hazard regression models. Kaplan–Meier curves were generated to evaluate the association between HGS and the 1 year mortality of patients with cancer cachexia. The interaction analysis was used to explore the combined effect of low HGS and other factors on the overall survival of patients with cancer cachexia. Results Among all participants, 1434 (16.9%) patients with cancer were diagnosed with cachexia according to the 2011 International cancer cachexia consensus with a mean (SD) age of 57.75 (12.97) years, among which there were 871 (60.7%) male patients. The HGS optimal cut‐off points of male and female patients were 19.87 and 14.3 kg, respectively. Patients with cancer cachexia had lower HGS than those patients without cachexia (P < 0.05). In the multivariable Cox analysis, low HGS was an independent risk factor of cachexia [HR: 1.491, 95% confidence interval (CI): 1.257–1.769] after adjusting other factors. In addition, all of cancer cachexia patients with lower HGS had unfavourable 1 year survival (P < 0.001). In a subset analysis, low HGS was an independent prognosis factor of male patients with cancer cachexia (HR: 1.623, 95% CI: 1.308–2.014, P < 0.001), but not in female patients (HR: 1.947, 95% CI: 0.956–3.963, P = 0.0662), and low HGS was associated with poor 1 year survival of digestive system, respiratory system, and other cancer cachexia patients (all P < 0.05). Low HGS has combined effects with high neutrophil‐to‐lymphocyte ratio or low albumin on unfavourable overall survival of patients with cancer cachexia. Conclusions Low HGS was associated with poor 1 year survival of patients with cancer cachexia. |
| first_indexed | 2024-04-24T08:50:31Z |
| format | Article |
| id | doaj.art-f2178dc3eb6b4182954d9562fa56c824 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2024-04-24T08:50:31Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-f2178dc3eb6b4182954d9562fa56c8242024-04-16T12:28:15ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092021-12-011261489150010.1002/jcsm.12778Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational studyMengmeng Song0Qi Zhang1Meng Tang2Xi Zhang3Guotian Ruan4Xiaowei Zhang5Kangping Zhang6Yizhong Ge7Ming Yang8Qinqin Li9Xiangrui Li10Xiaoyue Liu11Wei Li12Minghua Cong13Kunhua Wang14Chunhua Song15Hanping Shi16Department of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaCancer Center First Hospital of Jilin University Changchun Jilin ChinaDepartment of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences, Peking Union Medical College Beijing ChinaDepartment of Gastrointestinal Surgery The First Affiliated Hospital of Kunming Medical University Kunming ChinaDepartment of Epidemiology and Statistics, Henan Key Laboratory of Tumor Epidemiology College of Public Health Zhengzhou University Zhengzhou Henan ChinaDepartment of Gastrointestinal Surgery/Clinical Nutrition Capital Medical University Affiliated Beijing Shijitan Hospital Beijing ChinaAbstract Backgrounds Hand grip strength (HGS) is one of diagnose criteria factors of sarcopenia and is associated with the survival of patients with cancer. However, few studies have addressed the association of HGS and 1 year mortality of patients with cancer cachexia. Methods This cohort study included 8466 patients with malignant solid tumour from 40 clinical centres throughout China. Cachexia was diagnosed using the 2011 International cancer cachexia consensus. The hazard ratio (HR) of all cancer cachexia mortality was calculated using Cox proportional hazard regression models. Kaplan–Meier curves were generated to evaluate the association between HGS and the 1 year mortality of patients with cancer cachexia. The interaction analysis was used to explore the combined effect of low HGS and other factors on the overall survival of patients with cancer cachexia. Results Among all participants, 1434 (16.9%) patients with cancer were diagnosed with cachexia according to the 2011 International cancer cachexia consensus with a mean (SD) age of 57.75 (12.97) years, among which there were 871 (60.7%) male patients. The HGS optimal cut‐off points of male and female patients were 19.87 and 14.3 kg, respectively. Patients with cancer cachexia had lower HGS than those patients without cachexia (P < 0.05). In the multivariable Cox analysis, low HGS was an independent risk factor of cachexia [HR: 1.491, 95% confidence interval (CI): 1.257–1.769] after adjusting other factors. In addition, all of cancer cachexia patients with lower HGS had unfavourable 1 year survival (P < 0.001). In a subset analysis, low HGS was an independent prognosis factor of male patients with cancer cachexia (HR: 1.623, 95% CI: 1.308–2.014, P < 0.001), but not in female patients (HR: 1.947, 95% CI: 0.956–3.963, P = 0.0662), and low HGS was associated with poor 1 year survival of digestive system, respiratory system, and other cancer cachexia patients (all P < 0.05). Low HGS has combined effects with high neutrophil‐to‐lymphocyte ratio or low albumin on unfavourable overall survival of patients with cancer cachexia. Conclusions Low HGS was associated with poor 1 year survival of patients with cancer cachexia.https://doi.org/10.1002/jcsm.12778Cancer cachexiaHand grip strengthPrognosisMortality |
| spellingShingle | Mengmeng Song Qi Zhang Meng Tang Xi Zhang Guotian Ruan Xiaowei Zhang Kangping Zhang Yizhong Ge Ming Yang Qinqin Li Xiangrui Li Xiaoyue Liu Wei Li Minghua Cong Kunhua Wang Chunhua Song Hanping Shi Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study Journal of Cachexia, Sarcopenia and Muscle Cancer cachexia Hand grip strength Prognosis Mortality |
| title | Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study |
| title_full | Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study |
| title_fullStr | Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study |
| title_full_unstemmed | Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study |
| title_short | Associations of low hand grip strength with 1 year mortality of cancer cachexia: a multicentre observational study |
| title_sort | associations of low hand grip strength with 1 year mortality of cancer cachexia a multicentre observational study |
| topic | Cancer cachexia Hand grip strength Prognosis Mortality |
| url | https://doi.org/10.1002/jcsm.12778 |
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