The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum
Objective This study aims to investigate accuracy of group beta Streptococcus (GBS) rectovaginal cultures at 35 to 37 weeks in predicting intrapartum colonization. Study Design Institutional review board (IRB) approved prospective cohort study of 302 women from October 2015 to May 2017. P...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Thieme Medical Publishers, Inc.
2019-07-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1697655 |
| _version_ | 1819046231990599680 |
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| author | Farrah N. Hussain Zainab Al-Ibraheemi Stephanie Pan Antonia P. Francis Dyese Taylor Melissa Chu Lam Dawnette Lewis |
| author_facet | Farrah N. Hussain Zainab Al-Ibraheemi Stephanie Pan Antonia P. Francis Dyese Taylor Melissa Chu Lam Dawnette Lewis |
| author_sort | Farrah N. Hussain |
| collection | DOAJ |
| description | Objective This study aims to investigate accuracy of group beta Streptococcus (GBS) rectovaginal cultures at 35 to 37 weeks in predicting intrapartum colonization.
Study Design Institutional review board (IRB) approved prospective cohort study of 302 women from October 2015 to May 2017. Patients had the following tests for GBS: first trimester urine culture, rectovaginal culture at 35 to 37 weeks, and intrapartum rectovaginal culture. Outcomes included accuracy of 35- to 37-week GBS rectovaginal culture in detecting results intrapartum, and accuracy of first trimester urine culture in comparison to intrapartum rectovaginal cultures.
Results There was sufficient evidence of agreement between results at 35 to 37 weeks with intrapartum cultures (p = 0.001). However, agreement was weak, 11 patients (3.7%) were GBS positive intrapartum but negative at 35 to 37 weeks; and 33 patients (11%) were initially GBS positive but were negative intrapartum. Sensitivity and specificity of the 35- to 37-week culture was 69% (95% confidence interval [CI]:54–84%) and 87% (95% CI: 83–91%), respectively. There was also weak agreement between first trimester urine culture and intrapartum rectovaginal culture. Specificity for this assessment was 98% (95% CI: 97–100%) and was significantly different compared with antepartum GBS culture (p < 0.001). Accuracy between antepartum GBS rectovaginal culture and urine culture was similar (85 vs. 87%, p = 0.47).
Conclusion The 35- to 37-week GBS rectovaginal culture might be a poor predictor for intrapartum colonization. |
| first_indexed | 2024-12-21T10:41:11Z |
| format | Article |
| id | doaj.art-f2188b6d1cd14945998fd873e2e8bf9e |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-21T10:41:11Z |
| publishDate | 2019-07-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-f2188b6d1cd14945998fd873e2e8bf9e2022-12-21T19:06:56ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052019-07-010903e302e30910.1055/s-0039-1697655The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization IntrapartumFarrah N. Hussain0Zainab Al-Ibraheemi1Stephanie Pan2Antonia P. Francis3Dyese Taylor4Melissa Chu Lam5Dawnette Lewis6Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, New YorkDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, New YorkDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New YorkDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, New York University Langone Health, New York, New YorkDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, New YorkDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, New YorkDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai West, Icahn School of Medicine at Mount Sinai, New York, New YorkObjective This study aims to investigate accuracy of group beta Streptococcus (GBS) rectovaginal cultures at 35 to 37 weeks in predicting intrapartum colonization. Study Design Institutional review board (IRB) approved prospective cohort study of 302 women from October 2015 to May 2017. Patients had the following tests for GBS: first trimester urine culture, rectovaginal culture at 35 to 37 weeks, and intrapartum rectovaginal culture. Outcomes included accuracy of 35- to 37-week GBS rectovaginal culture in detecting results intrapartum, and accuracy of first trimester urine culture in comparison to intrapartum rectovaginal cultures. Results There was sufficient evidence of agreement between results at 35 to 37 weeks with intrapartum cultures (p = 0.001). However, agreement was weak, 11 patients (3.7%) were GBS positive intrapartum but negative at 35 to 37 weeks; and 33 patients (11%) were initially GBS positive but were negative intrapartum. Sensitivity and specificity of the 35- to 37-week culture was 69% (95% confidence interval [CI]:54–84%) and 87% (95% CI: 83–91%), respectively. There was also weak agreement between first trimester urine culture and intrapartum rectovaginal culture. Specificity for this assessment was 98% (95% CI: 97–100%) and was significantly different compared with antepartum GBS culture (p < 0.001). Accuracy between antepartum GBS rectovaginal culture and urine culture was similar (85 vs. 87%, p = 0.47). Conclusion The 35- to 37-week GBS rectovaginal culture might be a poor predictor for intrapartum colonization.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1697655bacterial colonizationbacteriuriachemoprophylaxismaternal infectionneonatal infectionobesitypregnancygroup β streptococcus screening methods |
| spellingShingle | Farrah N. Hussain Zainab Al-Ibraheemi Stephanie Pan Antonia P. Francis Dyese Taylor Melissa Chu Lam Dawnette Lewis The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum American Journal of Perinatology Reports bacterial colonization bacteriuria chemoprophylaxis maternal infection neonatal infection obesity pregnancy group β streptococcus screening methods |
| title | The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum |
| title_full | The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum |
| title_fullStr | The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum |
| title_full_unstemmed | The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum |
| title_short | The Accuracy of Group Beta Streptococcus Rectovaginal Cultures at 35 to 37 Weeks of Gestation in Predicting Colonization Intrapartum |
| title_sort | accuracy of group beta streptococcus rectovaginal cultures at 35 to 37 weeks of gestation in predicting colonization intrapartum |
| topic | bacterial colonization bacteriuria chemoprophylaxis maternal infection neonatal infection obesity pregnancy group β streptococcus screening methods |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1697655 |
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