Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats
Introduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and is known for its nutritional and medicinal uses. This study evaluated the protective effect of M. whitei fruit against cadmium-induced hepatic damage in rats. Methods: Twenty-five albino (Wistar strain) rats were random...
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| Format: | Article |
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Shahrekord University of Medical Sciences
2023-01-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://herbmedpharmacol.com/PDF/jhp-12-159.pdf |
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| author | Scholastica O. Anadozie Olusola B. Adewale Oluwole B. Akawa Juliet N. Olayinka Olukemi A. Osukoya Margaret M. Umanah Oyindamola A. Olaoye Oluwatosin S. Oludoro |
| author_facet | Scholastica O. Anadozie Olusola B. Adewale Oluwole B. Akawa Juliet N. Olayinka Olukemi A. Osukoya Margaret M. Umanah Oyindamola A. Olaoye Oluwatosin S. Oludoro |
| author_sort | Scholastica O. Anadozie |
| collection | DOAJ |
| description | Introduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and is known for its nutritional and medicinal uses. This study evaluated the protective effect of M. whitei fruit against cadmium-induced hepatic damage in rats. Methods: Twenty-five albino (Wistar strain) rats were randomly assigned into five equal groups. Rats in group I served as control, rats in group II were intoxicated with 5 mg/kg body weight (b.w.) cadmium chloride (CdCl2 ) for 5 days via an oral route, while groups III, IV, and V were respectively administered with 5 mg/kg b.w. CdCl2 for 5 days co-treated with 70 mg/kg b.w silymarin, 250 and 500 mg/kg b.w. of aqueous fruit extract of M. whitei (AEMW) for 7 days. Results: Cadmium caused a significant (P<0.05) increase in the concentration of cadmium in the liver as well as liver function markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. In addition, a significant (P<0.05) elevation in the level of malondialdehyde (MDA) and a reduction in the nitric oxide (NO) and antioxidant status were noted in the CdCl2 -exposed rats; hepatic degeneration and congested portal area were also noted. These changes were, however, reduced in the cadmium-intoxicated rats co-treated with silymarin, 250 mg/kg or 500 mg/kg AEMW. Conclusion: Our result suggests that AEMW exerts protective effects against CdCl2 -induced hepatic damage in rats, and this might be due to the presence of phytochemicals in the plant capable of scavenging oxidative stress caused by cadmium. |
| first_indexed | 2024-04-09T16:01:18Z |
| format | Article |
| id | doaj.art-f2194e299e61473c9dcf6099e555112f |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-09T16:01:18Z |
| publishDate | 2023-01-01 |
| publisher | Shahrekord University of Medical Sciences |
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| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-f2194e299e61473c9dcf6099e555112f2023-04-25T12:41:54ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042023-01-0112115916710.34172/jhp.2023.16jhp-44486Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in ratsScholastica O. Anadozie0Olusola B. Adewale1Oluwole B. Akawa2Juliet N. Olayinka3Olukemi A. Osukoya4Margaret M. Umanah5Oyindamola A. Olaoye6Oluwatosin S. Oludoro7Biochemistry Program, Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaBiochemistry Program, Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaDepartment of Pharmacology and Toxicology, College of Pharmacy, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaDepartment of Pharmacology and Therapeutics, College of Medicine and Health Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaBiochemistry Program, Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaBiochemistry Program, Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaBiochemistry Program, Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaChemistry Program (Environmental Chemistry), Department of Chemical Sciences, Afe Babalola University, P.M.B 5454, Ado-Ekiti, NigeriaIntroduction: Mondia whitei (Hook.f.) Skeels is rich in antioxidant activity and is known for its nutritional and medicinal uses. This study evaluated the protective effect of M. whitei fruit against cadmium-induced hepatic damage in rats. Methods: Twenty-five albino (Wistar strain) rats were randomly assigned into five equal groups. Rats in group I served as control, rats in group II were intoxicated with 5 mg/kg body weight (b.w.) cadmium chloride (CdCl2 ) for 5 days via an oral route, while groups III, IV, and V were respectively administered with 5 mg/kg b.w. CdCl2 for 5 days co-treated with 70 mg/kg b.w silymarin, 250 and 500 mg/kg b.w. of aqueous fruit extract of M. whitei (AEMW) for 7 days. Results: Cadmium caused a significant (P<0.05) increase in the concentration of cadmium in the liver as well as liver function markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. In addition, a significant (P<0.05) elevation in the level of malondialdehyde (MDA) and a reduction in the nitric oxide (NO) and antioxidant status were noted in the CdCl2 -exposed rats; hepatic degeneration and congested portal area were also noted. These changes were, however, reduced in the cadmium-intoxicated rats co-treated with silymarin, 250 mg/kg or 500 mg/kg AEMW. Conclusion: Our result suggests that AEMW exerts protective effects against CdCl2 -induced hepatic damage in rats, and this might be due to the presence of phytochemicals in the plant capable of scavenging oxidative stress caused by cadmium.http://herbmedpharmacol.com/PDF/jhp-12-159.pdfalanine transaminaseliver damagemalondialdehydeoxidative stressphytochemical |
| spellingShingle | Scholastica O. Anadozie Olusola B. Adewale Oluwole B. Akawa Juliet N. Olayinka Olukemi A. Osukoya Margaret M. Umanah Oyindamola A. Olaoye Oluwatosin S. Oludoro Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats Journal of HerbMed Pharmacology alanine transaminase liver damage malondialdehyde oxidative stress phytochemical |
| title | Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats |
| title_full | Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats |
| title_fullStr | Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats |
| title_full_unstemmed | Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats |
| title_short | Protective effect of aqueous fruit extract of Mondia whitei against cadmium-induced hepatotoxicity in rats |
| title_sort | protective effect of aqueous fruit extract of mondia whitei against cadmium induced hepatotoxicity in rats |
| topic | alanine transaminase liver damage malondialdehyde oxidative stress phytochemical |
| url | http://herbmedpharmacol.com/PDF/jhp-12-159.pdf |
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