Is osteoarthritis a mechanical or inflammatory disease?
Traditionally considered "wear and tear" disease, the pathogenic mechanisms of osteoarthritis have not yet been elucidated. The increasing number of articles demonstrating the influence of inflammatory factors in the onset and progression of the disease currently raises great debate in the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2013-12-01
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| Series: | Revista Brasileira de Ortopedia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000600471&lng=en&tlng=en |
| _version_ | 1827264020878458880 |
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| author | Marcia Uchoa de Rezend Gustavo Constantino de Campos |
| author_facet | Marcia Uchoa de Rezend Gustavo Constantino de Campos |
| author_sort | Marcia Uchoa de Rezend |
| collection | DOAJ |
| description | Traditionally considered "wear and tear" disease, the pathogenic mechanisms of osteoarthritis have not yet been elucidated. The increasing number of articles demonstrating the influence of inflammatory factors in the onset and progression of the disease currently raises great debate in the literature about the importance of each of the factors involved in the disease. Even the choice between the terms "Osteoarthritis" and "Osteoarthrosis" generates controversy, since the first term implies the presence of inflammation as the key generator of the disease, and the latter denotes a degenerative/mechanical causal factor. The aim of this revision article is to promote a debate on the influence of inflammatory factors and mechanical factors in the pathogenesis of OA. |
| first_indexed | 2024-03-08T07:42:31Z |
| format | Article |
| id | doaj.art-f21a4476ea864143896deed26563c5e7 |
| institution | Directory Open Access Journal |
| issn | 1982-4378 |
| language | English |
| last_indexed | 2025-03-22T03:39:25Z |
| publishDate | 2013-12-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Revista Brasileira de Ortopedia |
| spelling | doaj.art-f21a4476ea864143896deed26563c5e72024-04-28T12:06:32ZengThieme Revinter Publicações Ltda.Revista Brasileira de Ortopedia1982-43782013-12-0148647147410.1016/j.rboe.2013.12.002S0102-36162013000600471Is osteoarthritis a mechanical or inflammatory disease?Marcia Uchoa de RezendGustavo Constantino de CamposTraditionally considered "wear and tear" disease, the pathogenic mechanisms of osteoarthritis have not yet been elucidated. The increasing number of articles demonstrating the influence of inflammatory factors in the onset and progression of the disease currently raises great debate in the literature about the importance of each of the factors involved in the disease. Even the choice between the terms "Osteoarthritis" and "Osteoarthrosis" generates controversy, since the first term implies the presence of inflammation as the key generator of the disease, and the latter denotes a degenerative/mechanical causal factor. The aim of this revision article is to promote a debate on the influence of inflammatory factors and mechanical factors in the pathogenesis of OA.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000600471&lng=en&tlng=enOsteoartriteInflamacaoArtriteDoenca cronicaMecanica |
| spellingShingle | Marcia Uchoa de Rezend Gustavo Constantino de Campos Is osteoarthritis a mechanical or inflammatory disease? Revista Brasileira de Ortopedia Osteoartrite Inflamacao Artrite Doenca cronica Mecanica |
| title | Is osteoarthritis a mechanical or inflammatory disease? |
| title_full | Is osteoarthritis a mechanical or inflammatory disease? |
| title_fullStr | Is osteoarthritis a mechanical or inflammatory disease? |
| title_full_unstemmed | Is osteoarthritis a mechanical or inflammatory disease? |
| title_short | Is osteoarthritis a mechanical or inflammatory disease? |
| title_sort | is osteoarthritis a mechanical or inflammatory disease |
| topic | Osteoartrite Inflamacao Artrite Doenca cronica Mecanica |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-36162013000600471&lng=en&tlng=en |
| work_keys_str_mv | AT marciauchoaderezend isosteoarthritisamechanicalorinflammatorydisease AT gustavoconstantinodecampos isosteoarthritisamechanicalorinflammatorydisease |