Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana
Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance or not to treatment. Depending on the specie and multiple environmental parame...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1134020/full |
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| author | Nasreddine Saidi Nasreddine Saidi Romain Blaizot Romain Blaizot Romain Blaizot Ghislaine Prévot Karim Aoun Karim Aoun Magalie Demar Magalie Demar Magalie Demar Pierre André Cazenave Aida Bouratbine Aida Bouratbine Sylviane Pied |
| author_facet | Nasreddine Saidi Nasreddine Saidi Romain Blaizot Romain Blaizot Romain Blaizot Ghislaine Prévot Karim Aoun Karim Aoun Magalie Demar Magalie Demar Magalie Demar Pierre André Cazenave Aida Bouratbine Aida Bouratbine Sylviane Pied |
| author_sort | Nasreddine Saidi |
| collection | DOAJ |
| description | Cutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance or not to treatment. Depending on the specie and multiple environmental parameters, the evolution of lesions is determined by a complex interaction between parasite factors and the early immune responses triggered, including innate and adaptive mechanisms. Moreover, lesion resolution requires parasite control as well as modulation of the pathologic local inflammation responses and the initiation of wound healing responses. Here, we have summarized recent advances in understanding the in situ immune response to cutaneous leishmaniasis: i) in North Africa caused by Leishmania (L.) major, L. tropica, and L. infantum, which caused in most cases localized autoresolutives forms, and ii) in French Guiana resulting from L. guyanensis and L. braziliensis, two of the most prevalent strains that may induce potentially mucosal forms of the disease. This review will allow a better understanding of local immune parameters, including cellular and cytokines release in the lesion, that controls infection and/or protect against the pathogenesis in new world compared to old world CL. |
| first_indexed | 2024-03-12T21:21:18Z |
| format | Article |
| id | doaj.art-f21a6f94288b44f7a1f534d9797102e5 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T21:21:18Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f21a6f94288b44f7a1f534d9797102e52023-07-28T18:45:17ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.11340201134020Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French GuianaNasreddine Saidi0Nasreddine Saidi1Romain Blaizot2Romain Blaizot3Romain Blaizot4Ghislaine Prévot5Karim Aoun6Karim Aoun7Magalie Demar8Magalie Demar9Magalie Demar10Pierre André Cazenave11Aida Bouratbine12Aida Bouratbine13Sylviane Pied14Univ. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, FranceLaboratoire de Recherche, LR 16-IPT-06, Parasitoses Médicales, Biotechnologies et Biomolécules, Institut Pasteur de Tunis, Université Tunis El-Manar, Tunis, TunisiaUniv. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, FranceCentre National de Référence des Leishmanioses, Laboratoire Associé, Hôpital Andrée Rosemon, Cayenne, French Guiana, FranceService de Dermatologie, Hôpital de Cayenne, Cayenne, French Guiana, FranceUniv. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, FranceLaboratoire de Recherche, LR 16-IPT-06, Parasitoses Médicales, Biotechnologies et Biomolécules, Institut Pasteur de Tunis, Université Tunis El-Manar, Tunis, TunisiaService de Parasitologie-Mycologie, Institut Pasteur de Tunis, Tunis, TunisiaUniv. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, FranceCentre National de Référence des Leishmanioses, Laboratoire Associé, Hôpital Andrée Rosemon, Cayenne, French Guiana, FranceService de Dermatologie, Hôpital de Cayenne, Cayenne, French Guiana, FranceUniv. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, FranceLaboratoire de Recherche, LR 16-IPT-06, Parasitoses Médicales, Biotechnologies et Biomolécules, Institut Pasteur de Tunis, Université Tunis El-Manar, Tunis, TunisiaService de Parasitologie-Mycologie, Institut Pasteur de Tunis, Tunis, TunisiaUniv. Lille, Univ. French Guiana, CNRS UMR 9017-INSERM U1019, Center for Infection and Immunity of Lille-CIIL, Institut Pasteur de Lille, Lille, FranceCutaneous leishmaniasis (CL) caused by infection with the parasite Leishmania exhibits a large spectrum of clinical manifestations ranging from single healing to severe chronic lesions with the manifestation of resistance or not to treatment. Depending on the specie and multiple environmental parameters, the evolution of lesions is determined by a complex interaction between parasite factors and the early immune responses triggered, including innate and adaptive mechanisms. Moreover, lesion resolution requires parasite control as well as modulation of the pathologic local inflammation responses and the initiation of wound healing responses. Here, we have summarized recent advances in understanding the in situ immune response to cutaneous leishmaniasis: i) in North Africa caused by Leishmania (L.) major, L. tropica, and L. infantum, which caused in most cases localized autoresolutives forms, and ii) in French Guiana resulting from L. guyanensis and L. braziliensis, two of the most prevalent strains that may induce potentially mucosal forms of the disease. This review will allow a better understanding of local immune parameters, including cellular and cytokines release in the lesion, that controls infection and/or protect against the pathogenesis in new world compared to old world CL.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1134020/fullL. majorL. infantumL. tropicaL. guyanensisL. braziliensiscutaneous leishmaniasis (CL) |
| spellingShingle | Nasreddine Saidi Nasreddine Saidi Romain Blaizot Romain Blaizot Romain Blaizot Ghislaine Prévot Karim Aoun Karim Aoun Magalie Demar Magalie Demar Magalie Demar Pierre André Cazenave Aida Bouratbine Aida Bouratbine Sylviane Pied Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana Frontiers in Immunology L. major L. infantum L. tropica L. guyanensis L. braziliensis cutaneous leishmaniasis (CL) |
| title | Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana |
| title_full | Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana |
| title_fullStr | Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana |
| title_full_unstemmed | Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana |
| title_short | Clinical and immunological spectra of human cutaneous leishmaniasis in North Africa and French Guiana |
| title_sort | clinical and immunological spectra of human cutaneous leishmaniasis in north africa and french guiana |
| topic | L. major L. infantum L. tropica L. guyanensis L. braziliensis cutaneous leishmaniasis (CL) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1134020/full |
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