Salivary IgA versus HIV and Dental Caries
Introduction: The inter-relationship of Human Immunodeficiency Virus (HIV) infection and dental caries as well as Salivary Immunoglobulin-A (S-IgA) level appear to remain under explored while a manual and electronic search of the literature was made. Hence, the present study was undertaken to as...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8531/19394_CE(EK)_F(AK)_PF1(P-AG_AH)_PFA(AK)_PF2(PAG).pdf |
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| author | PRADIP KUMAR MANDAL MALAY MITRA SONU ACHARYA CHIRANJIT GHOSH SUSANT MOHANTY SUBRATA SAHA |
| author_facet | PRADIP KUMAR MANDAL MALAY MITRA SONU ACHARYA CHIRANJIT GHOSH SUSANT MOHANTY SUBRATA SAHA |
| author_sort | PRADIP KUMAR MANDAL |
| collection | DOAJ |
| description | Introduction: The inter-relationship of Human Immunodeficiency
Virus (HIV) infection and dental caries as well as Salivary
Immunoglobulin-A (S-IgA) level appear to remain under
explored while a manual and electronic search of the literature
was made. Hence, the present study was undertaken to assess
the relationship of S-IgA and dental caries status in HIV positive
children.
Aim: The aim of this study was to find out the relationship of S-IgA
antibody with dental caries by measuring the concentration of
IgA in saliva of HIV positive and negative children and determine
the dental caries status in HIV positive and HIV negative
children, which may help in treatment planning and prevention
of the same.
Materials and Methods: A total of 28 HIV positive children aged
between 6-14 years and 28 age matched HIV negative children
were included in this study and both samples were randomly
selected from the same Non-Governmental Organization
(NGO). The HIV status of both these samples was confirmed
from their medical records provided by the NGO. Only 2cc of
unstimulated saliva was collected from both groups in special
tubes coded numerically using the method described by Collins
and Dawes and the samples were analyzed to measure the
concentration of IgA using commercially available ELISA kit
(DRG Diagnostics, Germany). Examination of dental caries was
carried out according to WHO criteria (1997) using a flat mouth
mirror and CPI probe.
Results: In HIV +ve group mean S-IgA level was calculated as
81.61 ± 6.20 µg/ml, mean DMFT was 3.86 ± 3.37, mean deft was
4.75 ± 2.86. In HIV -ve group mean S-IgA level was calculated
as 145.57 ± 17.83µg/ml, mean DMFT was 2.54 ± 0.69, mean
deft was 2.43 ± 2.01.
Strong-ve correlation between S-IgA and DMFT (r = -0.781,
t = 6.38, p < 0.001) and negative but Not Significant (N.S.)
correlation (r = -0.19, t = 0.99, p > 0.05) between S-IgA and deft
was found in HIV +ve group. Strong –ve correlation between
S-IgA and DMFT (r = -0.655, t = 4.42, p < 0.001), S-IgA and deft
(r = -0.942, t =14.32, p=<0.001) was found in HIV-ve group.
Conclusion: This study suggests that the individuals who are
suffering from IgA deficiency in general, are more susceptible to
dental caries than normal individuals. |
| first_indexed | 2024-12-11T01:56:12Z |
| format | Article |
| id | doaj.art-f21d423a69e6481cb3a34ad3e80cd74f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T01:56:12Z |
| publishDate | 2016-09-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-f21d423a69e6481cb3a34ad3e80cd74f2022-12-22T01:24:37ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-09-01109ZC61ZC6410.7860/JCDR/2016/19394.8531Salivary IgA versus HIV and Dental CariesPRADIP KUMAR MANDAL0MALAY MITRA1SONU ACHARYA2CHIRANJIT GHOSH3SUSANT MOHANTY4SUBRATA SAHA5Senior Lecturer, Department of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, SOA University, Bhubaneswar, Odisha, India.Professor and Head of Department, Department of Pedodontics and Preventive Dentistry, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India.Professor, Department of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, SOA University, Bhubaneswar, Odisha, India.Senior Lecturer, Department of Pedodontics and Preventive Dentistry, Haldia Institute of Dental science and Research, Haldia, West Bengal, India.Professor and Head of Department, Department of Pedodontics and Preventive Dentistry, Institute of Dental Sciences, SOA University, Bhubaneswar, Odisha, India.Professor, Department of Pedodontics and Preventive Dentistry Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India.Introduction: The inter-relationship of Human Immunodeficiency Virus (HIV) infection and dental caries as well as Salivary Immunoglobulin-A (S-IgA) level appear to remain under explored while a manual and electronic search of the literature was made. Hence, the present study was undertaken to assess the relationship of S-IgA and dental caries status in HIV positive children. Aim: The aim of this study was to find out the relationship of S-IgA antibody with dental caries by measuring the concentration of IgA in saliva of HIV positive and negative children and determine the dental caries status in HIV positive and HIV negative children, which may help in treatment planning and prevention of the same. Materials and Methods: A total of 28 HIV positive children aged between 6-14 years and 28 age matched HIV negative children were included in this study and both samples were randomly selected from the same Non-Governmental Organization (NGO). The HIV status of both these samples was confirmed from their medical records provided by the NGO. Only 2cc of unstimulated saliva was collected from both groups in special tubes coded numerically using the method described by Collins and Dawes and the samples were analyzed to measure the concentration of IgA using commercially available ELISA kit (DRG Diagnostics, Germany). Examination of dental caries was carried out according to WHO criteria (1997) using a flat mouth mirror and CPI probe. Results: In HIV +ve group mean S-IgA level was calculated as 81.61 ± 6.20 µg/ml, mean DMFT was 3.86 ± 3.37, mean deft was 4.75 ± 2.86. In HIV -ve group mean S-IgA level was calculated as 145.57 ± 17.83µg/ml, mean DMFT was 2.54 ± 0.69, mean deft was 2.43 ± 2.01. Strong-ve correlation between S-IgA and DMFT (r = -0.781, t = 6.38, p < 0.001) and negative but Not Significant (N.S.) correlation (r = -0.19, t = 0.99, p > 0.05) between S-IgA and deft was found in HIV +ve group. Strong –ve correlation between S-IgA and DMFT (r = -0.655, t = 4.42, p < 0.001), S-IgA and deft (r = -0.942, t =14.32, p=<0.001) was found in HIV-ve group. Conclusion: This study suggests that the individuals who are suffering from IgA deficiency in general, are more susceptible to dental caries than normal individuals.https://jcdr.net/articles/PDF/8531/19394_CE(EK)_F(AK)_PF1(P-AG_AH)_PFA(AK)_PF2(PAG).pdfchilddeft indexdmft indeximmunodeficiencyimmunoglobulin |
| spellingShingle | PRADIP KUMAR MANDAL MALAY MITRA SONU ACHARYA CHIRANJIT GHOSH SUSANT MOHANTY SUBRATA SAHA Salivary IgA versus HIV and Dental Caries Journal of Clinical and Diagnostic Research child deft index dmft index immunodeficiency immunoglobulin |
| title | Salivary IgA versus HIV and Dental Caries |
| title_full | Salivary IgA versus HIV and Dental Caries |
| title_fullStr | Salivary IgA versus HIV and Dental Caries |
| title_full_unstemmed | Salivary IgA versus HIV and Dental Caries |
| title_short | Salivary IgA versus HIV and Dental Caries |
| title_sort | salivary iga versus hiv and dental caries |
| topic | child deft index dmft index immunodeficiency immunoglobulin |
| url | https://jcdr.net/articles/PDF/8531/19394_CE(EK)_F(AK)_PF1(P-AG_AH)_PFA(AK)_PF2(PAG).pdf |
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