The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study
<b>Background: </b>Preeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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King Faisal Specialist Hospital and Research Centre
2006-01-01
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| Series: | Annals of Saudi Medicine |
| Online Access: | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2006;volume=26;issue=2;spage=105;epage=109;aulast=Yalinkaya |
| _version_ | 1819157640023900160 |
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| author | Yalinkaya Ahmet Erdemoglu Mahmut Akdeniz Nurten Kale Ahmet Kale Ebru |
| author_facet | Yalinkaya Ahmet Erdemoglu Mahmut Akdeniz Nurten Kale Ahmet Kale Ebru |
| author_sort | Yalinkaya Ahmet |
| collection | DOAJ |
| description | <b>Background: </b>Preeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between thrombophilia and preeclamptic patients in our region. <b>Methods: </b>In a prospective case-control study, we compared 100 consecutive women with preeclampsia and eclampsia (group 1) with 100 normal pregnant women (group 2). All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III. <b>Results: </b>A thrombophilic mutation was found in 42 (42%) and 28 (28%) women in group 1 and group 2, respectively (<i>P</i>=0.27, OR 1.5, 95%CI 1.0- 2.2). The incidence of Factor V Leiden mutation (heterozygous), prothrombin mutation (heterozygous), prothrombin mutation (homozygous), MTHFR mutation (homozygous) was not statistically significant in group 1 compared with group 2 (<i>P</i>>0.05). Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 (<i>P </i>>0.05). <b>Conclusion: </b>There was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women in our region. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia. |
| first_indexed | 2024-12-22T16:11:58Z |
| format | Article |
| id | doaj.art-f21da3a560dd4bd09ef18d23485fc588 |
| institution | Directory Open Access Journal |
| issn | 0256-4947 0975-4466 |
| language | English |
| last_indexed | 2024-12-22T16:11:58Z |
| publishDate | 2006-01-01 |
| publisher | King Faisal Specialist Hospital and Research Centre |
| record_format | Article |
| series | Annals of Saudi Medicine |
| spelling | doaj.art-f21da3a560dd4bd09ef18d23485fc5882022-12-21T18:20:28ZengKing Faisal Specialist Hospital and Research CentreAnnals of Saudi Medicine0256-49470975-44662006-01-01262105109The relationship between thrombophilic mutations and preeclampsia : A prospective case-control studyYalinkaya AhmetErdemoglu MahmutAkdeniz NurtenKale AhmetKale Ebru<b>Background: </b>Preeclampsia and its association with thrombophilia remain controversial, due to inconsistent results in different studies, which include different ethnic groups, selection criteria, and patient numbers. The aim of this study was to determine the relationship between thrombophilia and preeclamptic patients in our region. <b>Methods: </b>In a prospective case-control study, we compared 100 consecutive women with preeclampsia and eclampsia (group 1) with 100 normal pregnant women (group 2). All women were tested two months after delivery for mutations of factor V Leiden, methylenetetrahydrofolate reductase (MTHFR), and prothrombin gene mutation as well as for deficiencies of protein C, protein S, and antithrombin III. <b>Results: </b>A thrombophilic mutation was found in 42 (42%) and 28 (28%) women in group 1 and group 2, respectively (<i>P</i>=0.27, OR 1.5, 95%CI 1.0- 2.2). The incidence of Factor V Leiden mutation (heterozygous), prothrombin mutation (heterozygous), prothrombin mutation (homozygous), MTHFR mutation (homozygous) was not statistically significant in group 1 compared with group 2 (<i>P</i>>0.05). Also, deficiencies of protein S, protein C, and antithrombin III were not statistically significant in group 1 compared with group 2 (<i>P </i>>0.05). <b>Conclusion: </b>There was no difference in thrombophilic mutations between preeclamptic patients and normal pregnant women in our region. Therefore, we suggest that preeclamptic patients should not be tested for thrombophilia.http://www.saudiannals.net/article.asp?issn=0256-4947;year=2006;volume=26;issue=2;spage=105;epage=109;aulast=Yalinkaya |
| spellingShingle | Yalinkaya Ahmet Erdemoglu Mahmut Akdeniz Nurten Kale Ahmet Kale Ebru The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study Annals of Saudi Medicine |
| title | The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study |
| title_full | The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study |
| title_fullStr | The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study |
| title_full_unstemmed | The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study |
| title_short | The relationship between thrombophilic mutations and preeclampsia : A prospective case-control study |
| title_sort | relationship between thrombophilic mutations and preeclampsia a prospective case control study |
| url | http://www.saudiannals.net/article.asp?issn=0256-4947;year=2006;volume=26;issue=2;spage=105;epage=109;aulast=Yalinkaya |
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