The hEag1 K<sup>+</sup> Channel Inhibitor Astemizole Stimulates Ca<sup>2+</sup> Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

The hEag1 K<sup>+</sup> Channel Inhibitor Astemizole Stimulates Ca<sup>2+</sup> Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

The hEag1 (Kv10.1) K<sup>+</sup> channel is normally found in the brain, but it is ectopically expressed in tumor cells, including osteosarcoma. Based on the pivotal role of ion channels in osteogenesis, we tested whether pharmacological modulation of hEag1 may affect osteogenic differen...

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Bibliographic Details
Main Authors: Beáta Mészáros, Agota Csoti, Tibor G. Szanto, Andrea Telek, Katalin Kovács, Agnes Toth, Julianna Volkó, Gyorgy Panyi
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
hEag1 potassium channel
SaOS-2 osteosarcoma cells
Ca<sup>2+</sup> deposition
Kv10.1
Online Access:https://www.mdpi.com/1422-0067/23/18/10533

Internet

https://www.mdpi.com/1422-0067/23/18/10533

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