The hEag1 K<sup>+</sup> Channel Inhibitor Astemizole Stimulates Ca<sup>2+</sup> Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

The hEag1 K<sup>+</sup> Channel Inhibitor Astemizole Stimulates Ca<sup>2+</sup> Deposition in SaOS-2 and MG-63 Osteosarcoma Cultures

The hEag1 (Kv10.1) K<sup>+</sup> channel is normally found in the brain, but it is ectopically expressed in tumor cells, including osteosarcoma. Based on the pivotal role of ion channels in osteogenesis, we tested whether pharmacological modulation of hEag1 may affect osteogenic differen...

Full description

Bibliographic Details
Main Authors:	Beáta Mészáros, Agota Csoti, Tibor G. Szanto, Andrea Telek, Katalin Kovács, Agnes Toth, Julianna Volkó, Gyorgy Panyi
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Series:	International Journal of Molecular Sciences
Subjects:	hEag1 potassium channel SaOS-2 osteosarcoma cells Ca<sup>2+</sup> deposition Kv10.1
Online Access:	https://www.mdpi.com/1422-0067/23/18/10533

Similar Items

Heterotridentate Organomonophosphines in Pt(κ<sup>3</sup>–X<sup>1</sup>P<sup>1</sup>X<sup>2</sup>)(Y) (X<sup>1,2</sup> = N<sup>1,2</sup> or S<sup>1,2</sup>), Pt(κ<sup>3</sup>–P<sup>1</sup>N<sup>1</sup>X<sup>1</sup>)(Y) (X<sup>1</sup> = O, C, S or Se) Pt(κ<sup>3</sup>–P<sup>1</sup>S<sup>1</sup>Cl<sup>1</sup>)(Cl) and Pt(κ<sup>3</sup>–P<sup>1</sup>Si<sup>1</sup>N<sup>1</sup>)(OL)—Structural Aspects
by: Milan Melník, et al.
Published: (2022-12-01)

Organomonophosphines in Pt(η<sup>3</sup>-X<sup>1</sup>X<sup>2</sup>X<sup>3</sup>)(PR<sub>3</sub>), (X = N<sup>1</sup>, N<sup>2</sup>, N<sup>3</sup>; S<sup>1</sup>, S<sup>2</sup>, S<sup>3</sup>; or Te<sup>1</sup>, Te<sup>2</sup>, Te<sup>3</sup>) Derivatives: Structural Aspects
by: Milan Melník, et al.
Published: (2023-06-01)

Glutamate-Evoked Ca<sup>2+</sup> Responses in the Rat Suprachiasmatic Nucleus: Involvement of Na<sup>+</sup>/K<sup>+</sup>-ATPase and Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger
by: Pi-Cheng Cheng, et al.
Published: (2023-03-01)

PD-1<sup>+</sup>CD8<sup>+</sup> T Cells Proximal to PD-L1<sup>+</sup>CD68<sup>+</sup> Macrophages Are Associated with Poor Prognosis in Pancreatic Ductal Adenocarcinoma Patients
by: Xiaobao Yang, et al.
Published: (2023-02-01)

Mitochondrial DNA tRNA<sup>Leu</sup> and tRNA<sup>Ser</sup> polymorphism in different pig breeds
by: M. A. Kolosova, et al.
Published: (2018-10-01)

Na<sup>+</sup>,K<sup>+</sup>-ATPase with Disrupted Na<sup>+</sup> Binding Sites I and III Binds Na<sup>+</sup> with Increased Affinity at Site II and Undergoes Na<sup>+</sup>-Activated Phosphorylation with ATP
by: Hang N. Nielsen, et al.
Published: (2024-01-01)

A Multifunctional Fluorescent Probe Based on 1,8-Naphthalimide for the Detection of Co<sup>2+</sup>, F<sup>−</sup>, and CN<sup>−</sup>
by: Ping Li, et al.
Published: (2023-06-01)

κO-SrVIA Conopeptide, a Novel Inhibitor Peptide for Two Members of the Human EAG Potassium Channel Family
by: Luis Martínez-Hernández, et al.
Published: (2023-07-01)

<it>Wld<sup>S </sup></it>but not Nmnat1 protects dopaminergic neurites from MPP<sup>+ </sup>neurotoxicity
by: Antenor-Dorsey Jo Ann V, et al.
Published: (2012-02-01)

ES-SCLC Patients with PD-L1<sup>+</sup> CTCs and High Percentages of CD8<sup>+</sup>PD-1<sup>+</sup>T Cells in Circulation Benefit from Front-Line Immunotherapy Treatment
by: Anastasia Xagara, et al.
Published: (2024-01-01)

The Pseudo-Protic Ionic Liquids TOAH<sup>+</sup>Cl<sup>−</sup> and TODAH<sup>+</sup>Cl<sup>−</sup> as Carriers for Facilitated Transport of In(III) from HCl Solutions
by: Francisco José Alguacil, et al.
Published: (2022-12-01)

Characterization of Monochromate and Hemichromate AFm Phases and Chromate-Containing Ettringite by <sup>1</sup>H, <sup>27</sup>Al, and <sup>53</sup>Cr MAS NMR Spectroscopy
by: Shuai Nie, et al.
Published: (2022-03-01)

Therapeutic Potential of <sup>47</sup>Sc in Comparison to <sup>177</sup>Lu and <sup>90</sup>Y: Preclinical Investigations
by: Klaudia Siwowska, et al.
Published: (2019-08-01)

Structural Aspects of Pt(η<sup>3</sup>–P<sup>1</sup>C<sub>2</sub>X<sup>1</sup>C<sub>2</sub>P<sup>2</sup>)(Y) Derivative Types
by: Milan Melník, et al.
Published: (2023-09-01)

Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca<sup>2+</sup>-Activated K<sup>+</sup> Currents While Inhibiting Voltage-Gated Na<sup>+</sup> Currents
by: Ming-Chi Lai, et al.
Published: (2022-11-01)

Hamster Sperm Possess Functional Na<sup>+</sup>/Ca<sup>2+</sup>-Exchanger 1: Its Implication in Hyperactivation
by: Gen L. Takei, et al.
Published: (2023-05-01)

Clinically Relevant <i>KCNQ1</i> Variants Causing KCNQ1-KCNE2 Gain-of-Function Affect the Ca<sup>2+</sup> Sensitivity of the Channel
by: Christiane K. Bauer, et al.
Published: (2022-08-01)

K<sup>+</sup> and Ca<sup>2+</sup> Channels Regulate Ca<sup>2+</sup> Signaling in Chondrocytes: An Illustrated Review
by: Yoshiaki Suzuki, et al.
Published: (2020-06-01)

XEN<sup>®</sup>-63 Compared to XEN<sup>®</sup>-45 Gel Stents to Reduce Intraocular Pressure in Glaucoma
by: Charlotte Evers, et al.
Published: (2023-07-01)

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose<sup>®</sup> 80, CombiLac<sup>®</sup>, MicroceLac<sup>®</sup> 100, and StarLac<sup>®</sup>
by: Martin Dominik, et al.
Published: (2021-09-01)

Regulation of p27<sup>Kip1</sup> and p57<sup>Kip2</sup> Functions by Natural Polyphenols
by: Gian Luigi Russo, et al.
Published: (2020-09-01)

Rare Earth Elements Geochemistry and <sup>234</sup>U/<sup>238</sup>U, <sup>235</sup>U/<sup>238</sup>U Isotope Ratios of the Kanyakumari Beach Placer Deposits: Occurrence and Provenance
by: Thennaarassan Natarajan, et al.
Published: (2023-06-01)

Safranal Induces Vasorelaxation by Inhibiting Ca<sup>2+</sup> Influx and Na<sup>+</sup>/Ca<sup>2+</sup> Exchanger in Isolated Rat Aortic Rings
by: Noor Nadhim Al-Saigh, et al.
Published: (2022-06-01)

Na<sup>+</sup>/H<sup>+</sup> Exchanger 1, a Potential Therapeutic Drug Target for Cardiac Hypertrophy and Heart Failure
by: Huiting Xia, et al.
Published: (2022-07-01)

CD3<sup>+</sup>, CD8<sup>+</sup>, CD4<sup>+</sup> and FOXP3<sup>+</sup> T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors
by: Niko Hiltunen, et al.
Published: (2021-06-01)

Spinach Plants Favor the Absorption of K<sup>+</sup> over Na<sup>+</sup> Regardless of Salinity, and May Benefit from Na<sup>+</sup> When K<sup>+</sup> is Deficient in the Soil
by: Jorge F. S. Ferreira, et al.
Published: (2020-04-01)

Stellar <i>β</i><sup>−</sup> Decay Rates for <sup>63</sup>Co and <sup>63</sup>Ni by the Projected Shell Model
by: Zi-Rui Chen, et al.
Published: (2023-01-01)

Meteoric <sup>10</sup>Be, <sup>137</sup>Cs and <sup>239+240</sup>Pu as Tracers of Long- and Medium-Term Soil Erosion—A Review
by: Aleksandra Loba, et al.
Published: (2022-03-01)

Piezoelectric A<sup>15</sup>B<sup>16</sup>C<sup>17</sup> Compounds and Their Nanocomposites for Energy Harvesting and Sensors: A Review
by: Piotr Szperlich
Published: (2021-11-01)

NAD<sup>+</sup> Homeostasis and NAD<sup>+</sup>-Consuming Enzymes: Implications for Vascular Health
by: Roberto Campagna, et al.
Published: (2023-02-01)

STOP1 Regulates <i>LKS1</i> Transcription and Coordinates K<sup>+</sup>/NH<sub>4</sub><sup>+</sup> Balance in <i>Arabidopsis</i> Response to Low-K<sup>+</sup> Stress
by: Zhi-Fang Wang, et al.
Published: (2021-12-01)

Chemical Separation of Uranium and Precise Measurement of <sup>234</sup>U/<sup>238</sup>U and <sup>235</sup>U/<sup>238</sup>U Ratios in Soil Samples Using Multi Collector Inductively Coupled Plasma Mass Spectrometry
by: Nimelan Veerasamy, et al.
Published: (2020-05-01)

CD34<sup>+</sup>CD10<sup>+</sup>CD19<sup>−</sup> Cells in Patients with Unhealthy Alcohol Use Stimulate the M2b Monocyte Polarization
by: Akira Asai, et al.
Published: (2022-08-01)

Spectroscopic Study of the 3107 cm<sup>−1</sup> and 3143 cm<sup>−1</sup> H-Related Defects in Type Ib Diamonds
by: Zhonghua Song, et al.
Published: (2022-09-01)

Heat-Affected-Zone Liquation Cracking in Welded Cast Haynes<sup>®</sup> 282<sup>®</sup>
by: Sukhdeep Singh, et al.
Published: (2019-12-01)

The Disordered EZH2 Loop: Atomic Level Characterization by <sup>1</sup>H<sup>N</sup>- and <sup>1</sup>H<sup>α</sup>-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA
by: Csenge Lilla Szabó, et al.
Published: (2022-05-01)

Wound Repair and Ca<sup>2+</sup> Signalling Interplay: The Role of Ca<sup>2+</sup> Channels in Skin
by: Gregorio Bonsignore, et al.
Published: (2024-03-01)

Effects of Oregano Essential Oil on IgA<sup>+</sup>, IgG<sup>+</sup>, and IgM<sup>+</sup> Cells in the Jejunum of Castrated Holstein Bulls
by: Qiyan Liu, et al.
Published: (2023-12-01)

<sup>1</sup>H-NMR-Based Metabonomics Study to Reveal the Progressive Metabolism Regulation of SAP Deficiency on ApoE<sup>−/−</sup> Mice
by: Qian Li, et al.
Published: (2022-12-01)

m<sup>1</sup>A RNA Modification in Gene Expression Regulation
by: Hao Jin, et al.
Published: (2022-05-01)