Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017
Abstract Background Diagnosis of tuberculosis (TB) in children is challenging. Epidemiological data of childhood pulmonary tuberculosis (PTB) are urgently needed. Methods We described trends in epidemiology, clinical characteristics, and treatment outcomes in seven cities of Shandong province, China...
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| Format: | Article |
| Language: | English |
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BMC
2019-05-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4060-x |
| _version_ | 1818271539508805632 |
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| author | Ning-ning Tao Yi-fan Li Yun-xia Liu Jin-yue Liu Wan-mei Song Yao Liu Hong Geng Shan-shan Wang Huai-chen Li |
| author_facet | Ning-ning Tao Yi-fan Li Yun-xia Liu Jin-yue Liu Wan-mei Song Yao Liu Hong Geng Shan-shan Wang Huai-chen Li |
| author_sort | Ning-ning Tao |
| collection | DOAJ |
| description | Abstract Background Diagnosis of tuberculosis (TB) in children is challenging. Epidemiological data of childhood pulmonary tuberculosis (PTB) are urgently needed. Methods We described trends in epidemiology, clinical characteristics, and treatment outcomes in seven cities of Shandong province, China, during 2005–2017. Data were collected from the China Information System for Disease Control and Prevention. Results Among 6283 (2.4% of all PTB) PTB cases aged < 18 years, 56.5% were male patients, 39.3% were smear-positive and 98.6% were new cases. The overall incidence of childhood PTB declined (7.62 to 3.74 per 100,000) during 2005–2017, with a non-significant change of annual percentage after 2010. While the incidence of smear-positive PTB (6.09 to 0.38 per 100,000 population) decreased significantly, but the incidence of smear-negative PTB (1.52 to 3.36 per 100,000 population) increased significantly during 2005–2017. The overall treatment success occurred among 94.2% childhood PTB. Ten children (0.2%) died. Conclusion The overall incidence of childhood PTB declined significantly with the disease burden shifting from smear-positive PTB to smear-negative PTB. The discrepancies between notifications and estimations in both TB morbidity and mortality of children need to be addressed urgently. |
| first_indexed | 2024-12-12T21:27:47Z |
| format | Article |
| id | doaj.art-f21fdd95694241578592a28b088a78d9 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-12T21:27:47Z |
| publishDate | 2019-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-f21fdd95694241578592a28b088a78d92022-12-22T00:11:25ZengBMCBMC Infectious Diseases1471-23342019-05-011911910.1186/s12879-019-4060-xEpidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017Ning-ning Tao0Yi-fan Li1Yun-xia Liu2Jin-yue Liu3Wan-mei Song4Yao Liu5Hong Geng6Shan-shan Wang7Huai-chen Li8Department of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Biostatistics, School of Public Health, Shandong UniversitySchool of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical SciencesDepartment of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong UniversityCenters for Tuberculosis Control in Shandong provinceDepartment of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong UniversityDepartment of Respiratory Medicine, Shandong Provincial Hospital Affiliated to Shandong UniversityAbstract Background Diagnosis of tuberculosis (TB) in children is challenging. Epidemiological data of childhood pulmonary tuberculosis (PTB) are urgently needed. Methods We described trends in epidemiology, clinical characteristics, and treatment outcomes in seven cities of Shandong province, China, during 2005–2017. Data were collected from the China Information System for Disease Control and Prevention. Results Among 6283 (2.4% of all PTB) PTB cases aged < 18 years, 56.5% were male patients, 39.3% were smear-positive and 98.6% were new cases. The overall incidence of childhood PTB declined (7.62 to 3.74 per 100,000) during 2005–2017, with a non-significant change of annual percentage after 2010. While the incidence of smear-positive PTB (6.09 to 0.38 per 100,000 population) decreased significantly, but the incidence of smear-negative PTB (1.52 to 3.36 per 100,000 population) increased significantly during 2005–2017. The overall treatment success occurred among 94.2% childhood PTB. Ten children (0.2%) died. Conclusion The overall incidence of childhood PTB declined significantly with the disease burden shifting from smear-positive PTB to smear-negative PTB. The discrepancies between notifications and estimations in both TB morbidity and mortality of children need to be addressed urgently.http://link.springer.com/article/10.1186/s12879-019-4060-xPulmonary tuberculosisPediatricIncidenceMortality |
| spellingShingle | Ning-ning Tao Yi-fan Li Yun-xia Liu Jin-yue Liu Wan-mei Song Yao Liu Hong Geng Shan-shan Wang Huai-chen Li Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017 BMC Infectious Diseases Pulmonary tuberculosis Pediatric Incidence Mortality |
| title | Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017 |
| title_full | Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017 |
| title_fullStr | Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017 |
| title_full_unstemmed | Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017 |
| title_short | Epidemiological characteristics of pulmonary tuberculosis among children in Shandong, China, 2005–2017 |
| title_sort | epidemiological characteristics of pulmonary tuberculosis among children in shandong china 2005 2017 |
| topic | Pulmonary tuberculosis Pediatric Incidence Mortality |
| url | http://link.springer.com/article/10.1186/s12879-019-4060-x |
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