The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis

The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis

BackgroundRhubarb is an important traditional Chinese medicine, and rhein is one of its most important active ingredients. Studies have found that rhein can improve ulcerative colitis by regulating gut microbes, but there are few reports on its effects on liver diseases. Therefore, this study aims t...

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Bibliographic Details
Main Authors: Shuhui Liu, Ruiying Yin, Ziwei Yang, Feili Wei, Jianhua Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
rhein
acute liver injury
gut microbiota
metabolomics
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.971409/full

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