| Summary: | Brown alga (Ishige okamurae; IO) dietary supplements have been reported
to possess anti-diabetic properties. However, the effects of IO supplements have not been
evaluated on glucose metabolism in the pancreas and skeletal muscle. C57BL/6 N male mice (age,
7 weeks) were arranged in five groups: a chow diet with 0.9% saline (NFD/saline group),
high-fat diet (HFD) with 0.9% saline (HFD/saline group). high-fat diet with 25 mg/kg IO
extract (HFD/25/IOE). high-fat diet with 50 mg/kg IO extract (HFD/50/IOE), and high-fat diet
with 75 mg/kg IO extract (HFD/75/IOE). After 4 weeks, the plasma, pancreas, and skeletal
muscle samples were collected for biochemical analyses. IOE significantly ameliorated glucose
tolerance impairment and fasting and 2 h blood glucose level in HFD mice. IOE also stimulated
the protein expressions of the glucose transporters (GLUTs) including GLUT2 and GLUT4 and
those of their related transcription factors in the pancreases and skeletal muscles of HFD
mice, enhanced glucose metabolism, and regulated blood glucose level. Our results suggest
Ishige okamurae extract may reduce blood glucose levels by improving glucose metabolism in the
pancreas and skeletal muscle in HFD-induced diabetes.
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