Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards
Infection is the leading cause of complications and deaths after burns. However, the difference in infection patterns between the burn intensive care unit (BICU) and burn common wards (BCW) have not been clearly investigated. The present study aimed to compare the infection profile, antimicrobial re...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2021.681731/full |
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| author | Yali Gong Yali Gong Yuan Peng Xiaoqiang Luo Xiaoqiang Luo Cheng Zhang Cheng Zhang Yunlong Shi Yunlong Shi Yixin Zhang Jun Deng Jun Deng Yizhi Peng Yizhi Peng Gaoxing Luo Gaoxing Luo Haisheng Li Haisheng Li |
| author_facet | Yali Gong Yali Gong Yuan Peng Xiaoqiang Luo Xiaoqiang Luo Cheng Zhang Cheng Zhang Yunlong Shi Yunlong Shi Yixin Zhang Jun Deng Jun Deng Yizhi Peng Yizhi Peng Gaoxing Luo Gaoxing Luo Haisheng Li Haisheng Li |
| author_sort | Yali Gong |
| collection | DOAJ |
| description | Infection is the leading cause of complications and deaths after burns. However, the difference in infection patterns between the burn intensive care unit (BICU) and burn common wards (BCW) have not been clearly investigated. The present study aimed to compare the infection profile, antimicrobial resistance, and their changing patterns in burn patients in BICU and BCW. Clinical samples were analyzed between January 1, 2011, and December 31, 2019, in the Institute of Burn Research in Southwest China. The patient information, pathogen distribution, sources, and antimicrobial resistance were retrospectively collected. A total of 3457 and 4219 strains were detected in BICU and BCW, respectively. Wound secretions accounted for 86.6% and 44.9% in BCW and BICU, respectively. Compared with samples in BCW, samples in BICU had more fungi (11.8% vs. 8.1%), more Gram-negative bacteria (60.0% vs. 50.8%), and less Gram-positive bacteria (28.2% vs. 41.1%). Acinetobacter baumannii were the most common pathogen in BICU, compared with Staphylococcus aureus in BCW. S. aureus was the most frequent pathogen in wound secretions and tissues from both BICU and BCW. However, A. baumannii were the first in blood, sputum, and catheter samples from BICU. Overall, the multidrug-resistance (MDR) rate was higher in BICU than in BCW. However, the gap between BICU and BCW gradually shortened from 2011 to 2019. The prevalence of MDR A. baumannii and Klebsiella pneumonia significantly increased, especially in BCW. Furthermore, Carbapenem resistance among K. pneumoniae significantly increased in BICU (4.5% in 2011 vs. 40% in 2019) and BCW (0 in 2011 vs. 40% in 2019). However, the percentage of MDR P. aeruginosa sharply dropped from 85.7% to 24.5% in BICU. The incidence of MRSA was significantly higher in BICU than in BCW (94.2% vs. 71.0%) and stayed at a high level in BICU (89.5% to 96.3%). C. tropicalis and C. albicans were the two most frequent fungi. No resistance to Amphotericin B was detected. Our study shows that the infection profile is different between BICU and BCW, and multidrug resistance is more serious in BICU than BCW. Therefore, different infection-control strategies should be emphasized in different burn populations. |
| first_indexed | 2024-12-22T01:02:39Z |
| format | Article |
| id | doaj.art-f225316bec444d8e963540f9462ac9c1 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-12-22T01:02:39Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f225316bec444d8e963540f9462ac9c12022-12-21T18:44:10ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-06-011110.3389/fcimb.2021.681731681731Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common WardsYali Gong0Yali Gong1Yuan Peng2Xiaoqiang Luo3Xiaoqiang Luo4Cheng Zhang5Cheng Zhang6Yunlong Shi7Yunlong Shi8Yixin Zhang9Jun Deng10Jun Deng11Yizhi Peng12Yizhi Peng13Gaoxing Luo14Gaoxing Luo15Haisheng Li16Haisheng Li17Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaInstitute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaState Key Laboratory of Trauma, Burns and Combined Injury, Chongqing, ChinaInfection is the leading cause of complications and deaths after burns. However, the difference in infection patterns between the burn intensive care unit (BICU) and burn common wards (BCW) have not been clearly investigated. The present study aimed to compare the infection profile, antimicrobial resistance, and their changing patterns in burn patients in BICU and BCW. Clinical samples were analyzed between January 1, 2011, and December 31, 2019, in the Institute of Burn Research in Southwest China. The patient information, pathogen distribution, sources, and antimicrobial resistance were retrospectively collected. A total of 3457 and 4219 strains were detected in BICU and BCW, respectively. Wound secretions accounted for 86.6% and 44.9% in BCW and BICU, respectively. Compared with samples in BCW, samples in BICU had more fungi (11.8% vs. 8.1%), more Gram-negative bacteria (60.0% vs. 50.8%), and less Gram-positive bacteria (28.2% vs. 41.1%). Acinetobacter baumannii were the most common pathogen in BICU, compared with Staphylococcus aureus in BCW. S. aureus was the most frequent pathogen in wound secretions and tissues from both BICU and BCW. However, A. baumannii were the first in blood, sputum, and catheter samples from BICU. Overall, the multidrug-resistance (MDR) rate was higher in BICU than in BCW. However, the gap between BICU and BCW gradually shortened from 2011 to 2019. The prevalence of MDR A. baumannii and Klebsiella pneumonia significantly increased, especially in BCW. Furthermore, Carbapenem resistance among K. pneumoniae significantly increased in BICU (4.5% in 2011 vs. 40% in 2019) and BCW (0 in 2011 vs. 40% in 2019). However, the percentage of MDR P. aeruginosa sharply dropped from 85.7% to 24.5% in BICU. The incidence of MRSA was significantly higher in BICU than in BCW (94.2% vs. 71.0%) and stayed at a high level in BICU (89.5% to 96.3%). C. tropicalis and C. albicans were the two most frequent fungi. No resistance to Amphotericin B was detected. Our study shows that the infection profile is different between BICU and BCW, and multidrug resistance is more serious in BICU than BCW. Therefore, different infection-control strategies should be emphasized in different burn populations.https://www.frontiersin.org/articles/10.3389/fcimb.2021.681731/fullburn infectionantimicrobial resistancemulti-drug resistancecarbapenem-resistant Gram-negative bacteriamethicillin-resistant Staphylococcus aureusfungi |
| spellingShingle | Yali Gong Yali Gong Yuan Peng Xiaoqiang Luo Xiaoqiang Luo Cheng Zhang Cheng Zhang Yunlong Shi Yunlong Shi Yixin Zhang Jun Deng Jun Deng Yizhi Peng Yizhi Peng Gaoxing Luo Gaoxing Luo Haisheng Li Haisheng Li Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards Frontiers in Cellular and Infection Microbiology burn infection antimicrobial resistance multi-drug resistance carbapenem-resistant Gram-negative bacteria methicillin-resistant Staphylococcus aureus fungi |
| title | Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards |
| title_full | Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards |
| title_fullStr | Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards |
| title_full_unstemmed | Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards |
| title_short | Different Infection Profiles and Antimicrobial Resistance Patterns Between Burn ICU and Common Wards |
| title_sort | different infection profiles and antimicrobial resistance patterns between burn icu and common wards |
| topic | burn infection antimicrobial resistance multi-drug resistance carbapenem-resistant Gram-negative bacteria methicillin-resistant Staphylococcus aureus fungi |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2021.681731/full |
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