Familial homozygous hypercholesterolemia in children: early diagnosis and treatment
Familial homozygous hypercholesterolemia is a rare life-threatening disease, the prevalence is 1: 160,000-1: 320,000. The main manifestation of the disease is an extremely high level of low-density lipoprotein cholesterol (more than 13 mmol / l), which causes early atherosclerotic vascular lesions,...
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| Format: | Article |
| Language: | Russian |
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Ltd. “The National Academy of Pediatric Science and Innovation”
2021-09-01
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| Series: | Rossijskij Vestnik Perinatologii i Pediatrii |
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| Online Access: | https://www.ped-perinatology.ru/jour/article/view/1453 |
| _version_ | 1797875138643886080 |
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| author | I. V. Leontyeva |
| author_facet | I. V. Leontyeva |
| author_sort | I. V. Leontyeva |
| collection | DOAJ |
| description | Familial homozygous hypercholesterolemia is a rare life-threatening disease, the prevalence is 1: 160,000-1: 320,000. The main manifestation of the disease is an extremely high level of low-density lipoprotein cholesterol (more than 13 mmol / l), which causes early atherosclerotic vascular lesions, including coronary arteries, starting from the first decade of life, and can lead to myocardial infarction in childhood. Familial homozygous hypercholesterolemia remains a little-known disease in the clinical practice of the pediatrician; it leads to delayed diagnosis and late initiation of therapy. The most common cause of the disease is mutations in the LDLR (90%) gene, less often in the APOB (5–10%), PCSK9 (1%), LDLRAP1 (1%) genes. The article presents the criteria for the diagnosis of familial homozygous hypercholesterolemia in children. The authors discuss clinical manifestations on the skin and at the level of the cardiovascular system, eyes. They present the strategy of management and the possibilities of treating patients. The paper presents the indications for the appointment and the effectiveness of statins, ezetrol, monoclonal antibodies to PCSK9, apheresis for the treatment of the disease. It discusses prospects for further therapy. |
| first_indexed | 2024-04-10T01:42:58Z |
| format | Article |
| id | doaj.art-f225f81228a1446f8340b0bebaf98212 |
| institution | Directory Open Access Journal |
| issn | 1027-4065 2500-2228 |
| language | Russian |
| last_indexed | 2024-04-10T01:42:58Z |
| publishDate | 2021-09-01 |
| publisher | Ltd. “The National Academy of Pediatric Science and Innovation” |
| record_format | Article |
| series | Rossijskij Vestnik Perinatologii i Pediatrii |
| spelling | doaj.art-f225f81228a1446f8340b0bebaf982122023-03-13T09:12:51ZrusLtd. “The National Academy of Pediatric Science and Innovation”Rossijskij Vestnik Perinatologii i Pediatrii1027-40652500-22282021-09-0166411812810.21508/1027-4065-2021-66-4-118-1281078Familial homozygous hypercholesterolemia in children: early diagnosis and treatmentI. V. Leontyeva0ОСП «Научно-исследовательский клинический институт педиатрии им. академика Ю. Е. Вельтищева», ФГАОУ ВО РНИМУ им. Н. И. Пирогова Минздрава РоссииFamilial homozygous hypercholesterolemia is a rare life-threatening disease, the prevalence is 1: 160,000-1: 320,000. The main manifestation of the disease is an extremely high level of low-density lipoprotein cholesterol (more than 13 mmol / l), which causes early atherosclerotic vascular lesions, including coronary arteries, starting from the first decade of life, and can lead to myocardial infarction in childhood. Familial homozygous hypercholesterolemia remains a little-known disease in the clinical practice of the pediatrician; it leads to delayed diagnosis and late initiation of therapy. The most common cause of the disease is mutations in the LDLR (90%) gene, less often in the APOB (5–10%), PCSK9 (1%), LDLRAP1 (1%) genes. The article presents the criteria for the diagnosis of familial homozygous hypercholesterolemia in children. The authors discuss clinical manifestations on the skin and at the level of the cardiovascular system, eyes. They present the strategy of management and the possibilities of treating patients. The paper presents the indications for the appointment and the effectiveness of statins, ezetrol, monoclonal antibodies to PCSK9, apheresis for the treatment of the disease. It discusses prospects for further therapy.https://www.ped-perinatology.ru/jour/article/view/1453детисемейная гомозиготная гиперхолестеринемиягиполипидемическая терапиякритерии диагностикигенетические аспекты |
| spellingShingle | I. V. Leontyeva Familial homozygous hypercholesterolemia in children: early diagnosis and treatment Rossijskij Vestnik Perinatologii i Pediatrii дети семейная гомозиготная гиперхолестеринемия гиполипидемическая терапия критерии диагностики генетические аспекты |
| title | Familial homozygous hypercholesterolemia in children: early diagnosis and treatment |
| title_full | Familial homozygous hypercholesterolemia in children: early diagnosis and treatment |
| title_fullStr | Familial homozygous hypercholesterolemia in children: early diagnosis and treatment |
| title_full_unstemmed | Familial homozygous hypercholesterolemia in children: early diagnosis and treatment |
| title_short | Familial homozygous hypercholesterolemia in children: early diagnosis and treatment |
| title_sort | familial homozygous hypercholesterolemia in children early diagnosis and treatment |
| topic | дети семейная гомозиготная гиперхолестеринемия гиполипидемическая терапия критерии диагностики генетические аспекты |
| url | https://www.ped-perinatology.ru/jour/article/view/1453 |
| work_keys_str_mv | AT ivleontyeva familialhomozygoushypercholesterolemiainchildrenearlydiagnosisandtreatment |