Characteristics, Isolation Methods, and Biological Properties of Aucubin
Aucubin is an iridoid glycoside widely spread in the families <i>Cornaceae</i>, <i>Garryaceae</i>, <i>Orobanchaceae</i>, <i>Globulariaceae</i>, <i>Eucommiaceae</i>, <i>Scrophulariaceae</i>, <i>Plantaginaceae</i>, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/10/4154 |
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| author | Kartini Kartini Michelle Abigail Irawan Finna Setiawan Nikmatul Ikhrom Eka Jayani |
| author_facet | Kartini Kartini Michelle Abigail Irawan Finna Setiawan Nikmatul Ikhrom Eka Jayani |
| author_sort | Kartini Kartini |
| collection | DOAJ |
| description | Aucubin is an iridoid glycoside widely spread in the families <i>Cornaceae</i>, <i>Garryaceae</i>, <i>Orobanchaceae</i>, <i>Globulariaceae</i>, <i>Eucommiaceae</i>, <i>Scrophulariaceae</i>, <i>Plantaginaceae</i>, and <i>Rubiaceae</i>. This review is intended to provide data on the physicochemical characteristics, isolation methods, and biological activities of aucubin and its producing plants. Aucubin is unstable and can be deglycosylated into its aglycone, aucubigenin. Various chromatographic methods (column chromatography, vacuum liquid chromatography, medium pressure liquid chromatography, and high-performance liquid chromatography) have been used together to isolate aucubin, mainly with the stationary phase C-18 and the mobile phase water–methanol solution made in gradients. In vitro and in vivo studies reveal that aucubin has a wide range of activities, including anti-inflammatory, antioxidant, anxiolytic and antidepressant, antidiabetic, antifibrotic, antimicrobial, anticancer, antihyperlipidemic, gastroprotective, cardioprotective, hepatoprotective, retinoprotective, neuroprotective, osteoprotective, and renoprotective. Even though aucubin has been extensively investigated, further research in humans is urgently needed primarily to substantiate the clinical evidence. Moreover, extensive studies on its drug delivery systems will help maximize efficacy and minimize side effects. |
| first_indexed | 2024-03-11T03:27:56Z |
| format | Article |
| id | doaj.art-f22726d7e1094e93adba0f5976569235 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T03:27:56Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f22726d7e1094e93adba0f59765692352023-11-18T02:40:03ZengMDPI AGMolecules1420-30492023-05-012810415410.3390/molecules28104154Characteristics, Isolation Methods, and Biological Properties of AucubinKartini Kartini0Michelle Abigail Irawan1Finna Setiawan2Nikmatul Ikhrom Eka Jayani3Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Surabaya 60293, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Surabaya 60293, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Surabaya 60293, IndonesiaDepartment of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Surabaya 60293, IndonesiaAucubin is an iridoid glycoside widely spread in the families <i>Cornaceae</i>, <i>Garryaceae</i>, <i>Orobanchaceae</i>, <i>Globulariaceae</i>, <i>Eucommiaceae</i>, <i>Scrophulariaceae</i>, <i>Plantaginaceae</i>, and <i>Rubiaceae</i>. This review is intended to provide data on the physicochemical characteristics, isolation methods, and biological activities of aucubin and its producing plants. Aucubin is unstable and can be deglycosylated into its aglycone, aucubigenin. Various chromatographic methods (column chromatography, vacuum liquid chromatography, medium pressure liquid chromatography, and high-performance liquid chromatography) have been used together to isolate aucubin, mainly with the stationary phase C-18 and the mobile phase water–methanol solution made in gradients. In vitro and in vivo studies reveal that aucubin has a wide range of activities, including anti-inflammatory, antioxidant, anxiolytic and antidepressant, antidiabetic, antifibrotic, antimicrobial, anticancer, antihyperlipidemic, gastroprotective, cardioprotective, hepatoprotective, retinoprotective, neuroprotective, osteoprotective, and renoprotective. Even though aucubin has been extensively investigated, further research in humans is urgently needed primarily to substantiate the clinical evidence. Moreover, extensive studies on its drug delivery systems will help maximize efficacy and minimize side effects.https://www.mdpi.com/1420-3049/28/10/4154aucubinbiological propertiesiridoidisolationphysicochemical properties |
| spellingShingle | Kartini Kartini Michelle Abigail Irawan Finna Setiawan Nikmatul Ikhrom Eka Jayani Characteristics, Isolation Methods, and Biological Properties of Aucubin Molecules aucubin biological properties iridoid isolation physicochemical properties |
| title | Characteristics, Isolation Methods, and Biological Properties of Aucubin |
| title_full | Characteristics, Isolation Methods, and Biological Properties of Aucubin |
| title_fullStr | Characteristics, Isolation Methods, and Biological Properties of Aucubin |
| title_full_unstemmed | Characteristics, Isolation Methods, and Biological Properties of Aucubin |
| title_short | Characteristics, Isolation Methods, and Biological Properties of Aucubin |
| title_sort | characteristics isolation methods and biological properties of aucubin |
| topic | aucubin biological properties iridoid isolation physicochemical properties |
| url | https://www.mdpi.com/1420-3049/28/10/4154 |
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