Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma
The rapid evolution of genomic technologies over the last years has led to the development of different methods for the detection, measurement and analysis of cell-free DNA fragments (cfDNA) which are shed into the bloodstream by apoptotic cells and circulate at a low concentration in plasma. In can...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | HemaSphere |
| Online Access: | http://journals.lww.com/10.1097/HS9.0000000000000727 |
| _version_ | 1797287401367797760 |
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| author | Maria Cristina Pirosa Sven Borchmann Fabrice Jardin Gianluca Gaidano Davide Rossi |
| author_facet | Maria Cristina Pirosa Sven Borchmann Fabrice Jardin Gianluca Gaidano Davide Rossi |
| author_sort | Maria Cristina Pirosa |
| collection | DOAJ |
| description | The rapid evolution of genomic technologies over the last years has led to the development of different methods for the detection, measurement and analysis of cell-free DNA fragments (cfDNA) which are shed into the bloodstream by apoptotic cells and circulate at a low concentration in plasma. In cancer patients, the proportion of tumor-derived cfDNA is defined as circulating tumor DNA. This analysis, commonly known as liquid biopsy, allows to access tumor DNA through a simple blood sampling and therefore without the need of an invasive tissue biopsy. For this reason, this tool may have several clinical applications in terms of diagnosis, prognosis, and monitoring of minimal residual disease. However, there are still several critical issues that need to be resolved. In this review, we will discuss some of the controversies around this method and its potential clinical applications. |
| first_indexed | 2024-03-07T18:32:35Z |
| format | Article |
| id | doaj.art-f227bce9f75b443c8a315d4a1cd9dc7a |
| institution | Directory Open Access Journal |
| issn | 2572-9241 |
| language | English |
| last_indexed | 2024-03-07T18:32:35Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | HemaSphere |
| spelling | doaj.art-f227bce9f75b443c8a315d4a1cd9dc7a2024-03-02T06:08:25ZengWileyHemaSphere2572-92412022-06-0166e72710.1097/HS9.0000000000000727202206000-00009Controversies in the Interpretation of Liquid Biopsy Data in LymphomaMaria Cristina Pirosa0Sven Borchmann1Fabrice Jardin2Gianluca Gaidano3Davide Rossi41 Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland3 Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Medical Faculty and University Hospital Cologne, University of Cologne, Germany5 Department of Hematology, Centre Henri Becquerel, Rouen, France6 Division of Hematology, Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy1 Division of Hematology, Oncology Institute of Southern Switzerland, Bellinzona, SwitzerlandThe rapid evolution of genomic technologies over the last years has led to the development of different methods for the detection, measurement and analysis of cell-free DNA fragments (cfDNA) which are shed into the bloodstream by apoptotic cells and circulate at a low concentration in plasma. In cancer patients, the proportion of tumor-derived cfDNA is defined as circulating tumor DNA. This analysis, commonly known as liquid biopsy, allows to access tumor DNA through a simple blood sampling and therefore without the need of an invasive tissue biopsy. For this reason, this tool may have several clinical applications in terms of diagnosis, prognosis, and monitoring of minimal residual disease. However, there are still several critical issues that need to be resolved. In this review, we will discuss some of the controversies around this method and its potential clinical applications.http://journals.lww.com/10.1097/HS9.0000000000000727 |
| spellingShingle | Maria Cristina Pirosa Sven Borchmann Fabrice Jardin Gianluca Gaidano Davide Rossi Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma HemaSphere |
| title | Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma |
| title_full | Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma |
| title_fullStr | Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma |
| title_full_unstemmed | Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma |
| title_short | Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma |
| title_sort | controversies in the interpretation of liquid biopsy data in lymphoma |
| url | http://journals.lww.com/10.1097/HS9.0000000000000727 |
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