The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?
Abstract Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study...
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| Format: | Article |
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Wiley
2021-04-01
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| Series: | DEN Open |
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| Online Access: | https://doi.org/10.1002/deo2.9 |
| _version_ | 1811337492187578368 |
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| author | Yoshiki Sakaguchi Yosuke Tsuji Tetsuo Ushiku Dai Kubota Junichi Sato Miho Obata Rina Cho Sayaka Nagao Nobuyuki Sakuma Naoki Tamura Yuko Miura Kazushi Fukagawa Daisuke Ohki Hiroya Mizutani Chihiro Takeuchi Yu Takahashi Chihiro Minatsuki Keiko Niimi Nobutake Yamamichi Kazuhiko Koike |
| author_facet | Yoshiki Sakaguchi Yosuke Tsuji Tetsuo Ushiku Dai Kubota Junichi Sato Miho Obata Rina Cho Sayaka Nagao Nobuyuki Sakuma Naoki Tamura Yuko Miura Kazushi Fukagawa Daisuke Ohki Hiroya Mizutani Chihiro Takeuchi Yu Takahashi Chihiro Minatsuki Keiko Niimi Nobutake Yamamichi Kazuhiko Koike |
| author_sort | Yoshiki Sakaguchi |
| collection | DOAJ |
| description | Abstract Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed‐up with upper gastrointestinal endoscopy for more than 6 months. Results During a follow‐up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer. |
| first_indexed | 2024-04-13T17:55:40Z |
| format | Article |
| id | doaj.art-f22a118eb5a040728ef88f69fe3f2c2b |
| institution | Directory Open Access Journal |
| issn | 2692-4609 |
| language | English |
| last_indexed | 2024-04-13T17:55:40Z |
| publishDate | 2021-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | DEN Open |
| spelling | doaj.art-f22a118eb5a040728ef88f69fe3f2c2b2022-12-22T02:36:32ZengWileyDEN Open2692-46092021-04-0111n/an/a10.1002/deo2.9The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see?Yoshiki Sakaguchi0Yosuke Tsuji1Tetsuo Ushiku2Dai Kubota3Junichi Sato4Miho Obata5Rina Cho6Sayaka Nagao7Nobuyuki Sakuma8Naoki Tamura9Yuko Miura10Kazushi Fukagawa11Daisuke Ohki12Hiroya Mizutani13Chihiro Takeuchi14Yu Takahashi15Chihiro Minatsuki16Keiko Niimi17Nobutake Yamamichi18Kazuhiko Koike19Department of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Pathology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanDepartment of Gastroenterology Graduate School of Medicine The University of Tokyo Tokyo JapanAbstract Objectives The natural history of sporadic non‐ampullary duodenal epithelial tumors (SNADETs) is poorly documented. The aim of this study was to evaluate the history of SNADETs in patients where immediate resection could not be performed. Methods This is a single‐center retrospective study of 86 consecutive cases of SNADETs who did not undergo immediate resection and were followed‐up with upper gastrointestinal endoscopy for more than 6 months. Results During a follow‐up period of 36.8 (6.0–613.0) months, macroscopic progression was admitted in eight (9.3%). Of these, the final histology in four was adenocarcinoma, and three cases demonstrated submucosal invasion. Rates of macroscopic progression at 150 months after detection were 11.1%, 16.7%, and 30.0% for SNADETs <5 mm, <10 mm, and ≥10 mm, respectively. Conclusion The overall risk of SNADETs progressing to invasive cancer is low. However, changes in macroscopic size or shape of SNADETs signify a high risk of progression to invasive cancer.https://doi.org/10.1002/deo2.9natural historysporadic non‐ampullary duodenal epithelial tumortumor progression |
| spellingShingle | Yoshiki Sakaguchi Yosuke Tsuji Tetsuo Ushiku Dai Kubota Junichi Sato Miho Obata Rina Cho Sayaka Nagao Nobuyuki Sakuma Naoki Tamura Yuko Miura Kazushi Fukagawa Daisuke Ohki Hiroya Mizutani Chihiro Takeuchi Yu Takahashi Chihiro Minatsuki Keiko Niimi Nobutake Yamamichi Kazuhiko Koike The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see? DEN Open natural history sporadic non‐ampullary duodenal epithelial tumor tumor progression |
| title | The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see? |
| title_full | The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see? |
| title_fullStr | The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see? |
| title_full_unstemmed | The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see? |
| title_short | The natural history of sporadic non‐ampullary duodenal epithelial tumors: Can we wait and see? |
| title_sort | natural history of sporadic non ampullary duodenal epithelial tumors can we wait and see |
| topic | natural history sporadic non‐ampullary duodenal epithelial tumor tumor progression |
| url | https://doi.org/10.1002/deo2.9 |
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