The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity.

The Ccr4-Not complex functions as an effector of multiple signaling pathways that control gene transcription and mRNA turnover. Consequently, Ccr4-Not contributes to a diverse array of processes, which includes a significant role in cell metabolism. Yet a mechanistic understanding of how it contribu...

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Bibliographic Details
Main Authors: Hongfeng Chen, P Winston Miller, Daniel L Johnson, R Nicholas Laribee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009046

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