Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study
OBJECTIVE: In this study, the relationship between the frequency of bronchopulmonary dysplasia, perinatal risk factors and other prematurity comorbidities were evaluated in very low birth weight infants. METHODS: A total of 872 very low birth weight infants' files were retrospectively reviewed....
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2020-03-01
|
| Series: | İstanbul Kuzey Klinikleri |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-23427 |
| _version_ | 1797912400781901824 |
|---|---|
| author | Turgay Cokyaman Sultan Kavuncuoglu |
| author_facet | Turgay Cokyaman Sultan Kavuncuoglu |
| author_sort | Turgay Cokyaman |
| collection | DOAJ |
| description | OBJECTIVE: In this study, the relationship between the frequency of bronchopulmonary dysplasia, perinatal risk factors and other prematurity comorbidities were evaluated in very low birth weight infants.
METHODS: A total of 872 very low birth weight infants' files were retrospectively reviewed. The effects of the clinical parameters, such as type of birth, small for gestational age, gender, antenatal steroids, early membrane rupture, chorioamnionitis, surfactant administration, respiratory distress syndrome, patent ductus arteriosus, apnea, early and late sepsis on the frequency of bronchopulmonary dysplasia, were evaluated by binary logistic regression analysis.
RESULTS: The overall mortality rate was 20.9%. After the first 28-day mortality reduction, the total bronchopulmonary dysplasia frequency was found to be 20.1%. The odds ratio and 95% confidence intervals of the factors affecting the development of bronchopulmonary dysplasia were found to be as follows respectively: respiratory distress syndrome (OR 6.2, 95% CI 3.6–10.6, p<0.01), patent ductus arteriosus (OR 4.9, 95% Cl 2.4–9.9, p<0.01), apnea (OR 4.1, 95% CI 2.5–6.9, p<0.01), late sepsis (OR 2.7, 95% CI 1.6–4.5, p<0.01), early membrane rupture (OR 2.6, 95% Cl 1.2–5.5, p=0.01), and male gender (OR 1.6, 95% CI 1.0-2.7, p=0.04) was found. However, there was no effect of chorioamnionitis, antenatal steroids, small for gestational age, early sepsis and type of birth on bronchopulmonary dysplasia.
CONCLUSION: Differently from the usual factors which are low birth weight and a gestational week, there was a significant but non-linear risk relationship between respiratory distress syndrome, patent ductus arteriosus, late sepsis, apnea, early membrane rupture, male gender and bronchopulmonary dysplasia. |
| first_indexed | 2024-04-10T11:55:24Z |
| format | Article |
| id | doaj.art-f22e5c38721a4acebf5988ed3ffe406b |
| institution | Directory Open Access Journal |
| issn | 2148-4902 |
| language | English |
| last_indexed | 2024-04-10T11:55:24Z |
| publishDate | 2020-03-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | İstanbul Kuzey Klinikleri |
| spelling | doaj.art-f22e5c38721a4acebf5988ed3ffe406b2023-02-15T16:16:51ZengKARE Publishingİstanbul Kuzey Klinikleri2148-49022020-03-017212413010.14744/nci.2019.23427NCI-23427Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective studyTurgay Cokyaman0Sultan Kavuncuoglu1Department of Pediatrics, Istanbul Bakirkoy Maternity and Children's Research and Training Hospital, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Bakirkoy Maternity and Children's Research and Training Hospital, Istanbul, TurkeyOBJECTIVE: In this study, the relationship between the frequency of bronchopulmonary dysplasia, perinatal risk factors and other prematurity comorbidities were evaluated in very low birth weight infants. METHODS: A total of 872 very low birth weight infants' files were retrospectively reviewed. The effects of the clinical parameters, such as type of birth, small for gestational age, gender, antenatal steroids, early membrane rupture, chorioamnionitis, surfactant administration, respiratory distress syndrome, patent ductus arteriosus, apnea, early and late sepsis on the frequency of bronchopulmonary dysplasia, were evaluated by binary logistic regression analysis. RESULTS: The overall mortality rate was 20.9%. After the first 28-day mortality reduction, the total bronchopulmonary dysplasia frequency was found to be 20.1%. The odds ratio and 95% confidence intervals of the factors affecting the development of bronchopulmonary dysplasia were found to be as follows respectively: respiratory distress syndrome (OR 6.2, 95% CI 3.6–10.6, p<0.01), patent ductus arteriosus (OR 4.9, 95% Cl 2.4–9.9, p<0.01), apnea (OR 4.1, 95% CI 2.5–6.9, p<0.01), late sepsis (OR 2.7, 95% CI 1.6–4.5, p<0.01), early membrane rupture (OR 2.6, 95% Cl 1.2–5.5, p=0.01), and male gender (OR 1.6, 95% CI 1.0-2.7, p=0.04) was found. However, there was no effect of chorioamnionitis, antenatal steroids, small for gestational age, early sepsis and type of birth on bronchopulmonary dysplasia. CONCLUSION: Differently from the usual factors which are low birth weight and a gestational week, there was a significant but non-linear risk relationship between respiratory distress syndrome, patent ductus arteriosus, late sepsis, apnea, early membrane rupture, male gender and bronchopulmonary dysplasia.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-23427bronchopulmonary dysplasiapremature infant. |
| spellingShingle | Turgay Cokyaman Sultan Kavuncuoglu Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study İstanbul Kuzey Klinikleri bronchopulmonary dysplasia premature infant. |
| title | Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study |
| title_full | Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study |
| title_fullStr | Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study |
| title_full_unstemmed | Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study |
| title_short | Bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants: A 3-year retrospective study |
| title_sort | bronchopulmonary dysplasia frequency and risk factors in very low birth weight infants a 3 year retrospective study |
| topic | bronchopulmonary dysplasia premature infant. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=nci&un=NCI-23427 |
| work_keys_str_mv | AT turgaycokyaman bronchopulmonarydysplasiafrequencyandriskfactorsinverylowbirthweightinfantsa3yearretrospectivestudy AT sultankavuncuoglu bronchopulmonarydysplasiafrequencyandriskfactorsinverylowbirthweightinfantsa3yearretrospectivestudy |