Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil
Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Bra...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/2/585 |
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| author | Mariane Talon de Menezes Filipe Romero Rebello Moreira Charles Whittaker Franciele Martins Santos Daniel Costa Queiroz Victor Geddes Paula Luize Camargos Fonseca Jaqueline Góes de Jesus Franciane Mendes-Oliveira Valquíria Reis-Souza Bibiana Santos Danielle Alves Gomes Zauli Aline Brito de Lima Cristiane de Brito Mendonça Luige Biciati Alvim Joice do Prado Silva Frederico Scott Varella Malta Alessandro Clayton de Souza Ferreira Nuno R. Faria Ester Cerdeira Sabino Renato Santana Aguiar |
| author_facet | Mariane Talon de Menezes Filipe Romero Rebello Moreira Charles Whittaker Franciele Martins Santos Daniel Costa Queiroz Victor Geddes Paula Luize Camargos Fonseca Jaqueline Góes de Jesus Franciane Mendes-Oliveira Valquíria Reis-Souza Bibiana Santos Danielle Alves Gomes Zauli Aline Brito de Lima Cristiane de Brito Mendonça Luige Biciati Alvim Joice do Prado Silva Frederico Scott Varella Malta Alessandro Clayton de Souza Ferreira Nuno R. Faria Ester Cerdeira Sabino Renato Santana Aguiar |
| author_sort | Mariane Talon de Menezes |
| collection | DOAJ |
| description | Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG. |
| first_indexed | 2024-03-11T08:00:15Z |
| format | Article |
| id | doaj.art-f23062f2b6a146919573a2e4a4cb3752 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T08:00:15Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f23062f2b6a146919573a2e4a4cb37522023-11-16T23:51:00ZengMDPI AGViruses1999-49152023-02-0115258510.3390/v15020585Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, BrazilMariane Talon de Menezes0Filipe Romero Rebello Moreira1Charles Whittaker2Franciele Martins Santos3Daniel Costa Queiroz4Victor Geddes5Paula Luize Camargos Fonseca6Jaqueline Góes de Jesus7Franciane Mendes-Oliveira8Valquíria Reis-Souza9Bibiana Santos10Danielle Alves Gomes Zauli11Aline Brito de Lima12Cristiane de Brito Mendonça13Luige Biciati Alvim14Joice do Prado Silva15Frederico Scott Varella Malta16Alessandro Clayton de Souza Ferreira17Nuno R. Faria18Ester Cerdeira Sabino19Renato Santana Aguiar20Laboratory of Molecular Virology, Institute of Biology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, BrazilLaboratory of Molecular Virology, Institute of Biology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, BrazilMRC Centre for Global Infectious Disease Analysis, Imperial College London, London SW7 2BX, UKLaboratory of Integrative Biology, Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270, BrazilLaboratory of Integrative Biology, Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270, BrazilLaboratory of Integrative Biology, Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270, BrazilLaboratory of Integrative Biology, Department of Genetics, Ecology and Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte 31270, BrazilInstitute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo 04023, BrazilInstitute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo 04023, BrazilInstitute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo 04023, BrazilMendelics Genomic Analysis, São Paulo 04023, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilPardini Group, Research and Development Department, Belo Horizonte 31270, BrazilMRC Centre for Global Infectious Disease Analysis, Imperial College London, London SW7 2BX, UKInstitute of Tropical Medicine, Faculty of Medicine, University of São Paulo, São Paulo 04023, BrazilLaboratory of Molecular Virology, Institute of Biology, Department of Genetics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-901, BrazilBrazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.https://www.mdpi.com/1999-4915/15/2/585OmicronSARS-CoV-2genomic surveillancevariants of concernviral evolution |
| spellingShingle | Mariane Talon de Menezes Filipe Romero Rebello Moreira Charles Whittaker Franciele Martins Santos Daniel Costa Queiroz Victor Geddes Paula Luize Camargos Fonseca Jaqueline Góes de Jesus Franciane Mendes-Oliveira Valquíria Reis-Souza Bibiana Santos Danielle Alves Gomes Zauli Aline Brito de Lima Cristiane de Brito Mendonça Luige Biciati Alvim Joice do Prado Silva Frederico Scott Varella Malta Alessandro Clayton de Souza Ferreira Nuno R. Faria Ester Cerdeira Sabino Renato Santana Aguiar Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil Viruses Omicron SARS-CoV-2 genomic surveillance variants of concern viral evolution |
| title | Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil |
| title_full | Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil |
| title_fullStr | Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil |
| title_full_unstemmed | Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil |
| title_short | Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil |
| title_sort | dynamics of early establishment of sars cov 2 voc omicron lineages in minas gerais brazil |
| topic | Omicron SARS-CoV-2 genomic surveillance variants of concern viral evolution |
| url | https://www.mdpi.com/1999-4915/15/2/585 |
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