BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY
Aim of the study Medication related osteonecrosis of the jaw (MRONJ) is a severe drug adverse effect, often being diagnosed in an advanced stage. The aim of this epidemiological study was to determine the frequency of MRONJ in cancer patients from Oltenia region, during 2012-2017. Material and metho...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Romanian Society of Oral Rehabilitation
2022-08-01
|
| Series: | Romanian Journal of Oral Rehabilitation |
| Subjects: | |
| Online Access: | https://www.rjor.ro/bisphosphonates-related-osteonecrosis-of-the-jaw-in-cancer-patients-epidemiological-study/ |
| _version_ | 1828004277535113216 |
|---|---|
| author | George Adrian Ciobanu Adrian Camen Mihaela Ionescu Daniel Vlad Veronica Mercuț Ionela Elisabeta Staicu Gabriel Sebastian Petrescu Adel Aila Asan Sanda Mihaela Popescu |
| author_facet | George Adrian Ciobanu Adrian Camen Mihaela Ionescu Daniel Vlad Veronica Mercuț Ionela Elisabeta Staicu Gabriel Sebastian Petrescu Adel Aila Asan Sanda Mihaela Popescu |
| author_sort | George Adrian Ciobanu |
| collection | DOAJ |
| description | Aim of the study Medication related osteonecrosis of the jaw (MRONJ) is a severe drug adverse effect, often being diagnosed in an advanced stage. The aim of this epidemiological study was to determine the frequency of MRONJ in cancer patients from Oltenia region, during 2012-2017. Material and methods Data retrieved from the clinical charts and used in this study were age, gender, residency, neoplasm type, location, and stage of MRONJ. Microsoft Excel and SPSS for Windows were used for analysis. Results The study included 57 patients, 31 females and 26 males, mean age 63.8±9.8. MRONJ was found in older patients, females mostly under 65 years old, males mostly over 65 years old (p = 0.023). Age distribution was correlated with the neoplasm type, while median ages between the breast neoplasm (58.5 years old) and prostate neoplasm (70 years old) groups were significantly different (p = 0.002). All patients with MRONJ have been previously treated with intravenous zoledronic acid for bone metastasis. Mandibular MRONJ was 2.35 times more frequent than maxillary MRONJ (p = 0.002) and stage II of MRONJ was commonly encountered. Conclusions MRONJ has been found mostly in patients with breast or prostate adenoma cancers with bone metastases who have been treated with intravenous. zoledronic acid and was present especially in the lower jaw, in advanced stages. |
| first_indexed | 2024-04-10T07:12:27Z |
| format | Article |
| id | doaj.art-f2315f100f0d455a8f590b0b2241c100 |
| institution | Directory Open Access Journal |
| issn | 2066-7000 2601-4661 |
| language | English |
| last_indexed | 2024-04-10T07:12:27Z |
| publishDate | 2022-08-01 |
| publisher | Romanian Society of Oral Rehabilitation |
| record_format | Article |
| series | Romanian Journal of Oral Rehabilitation |
| spelling | doaj.art-f2315f100f0d455a8f590b0b2241c1002023-02-26T10:41:21ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612022-08-011435666BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDYGeorge Adrian Ciobanu0Adrian Camen1Mihaela Ionescu2Daniel Vlad3Veronica Mercuț4Ionela Elisabeta Staicu5Gabriel Sebastian Petrescu6Adel Aila Asan7Sanda Mihaela Popescu8University of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of Oral RehabilitationUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of Oral and Maxillofacial SurgeryUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of Medical Informatics and Biostatistics"Ovidius" University of Constanta, Romania, Dental Medicine Faculty, Department of Oral and Maxillofacial SurgeryUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of ProsthodonticsUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of OrthodonticsUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of Oral and Maxillofacial SurgeryThe County Emergency Clinical Hospital “Sf. Apostol Andrei” Constanta, Department of Oral and Maxillofacial SurgeryUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dental Medicine, Department of Oral RehabilitationAim of the study Medication related osteonecrosis of the jaw (MRONJ) is a severe drug adverse effect, often being diagnosed in an advanced stage. The aim of this epidemiological study was to determine the frequency of MRONJ in cancer patients from Oltenia region, during 2012-2017. Material and methods Data retrieved from the clinical charts and used in this study were age, gender, residency, neoplasm type, location, and stage of MRONJ. Microsoft Excel and SPSS for Windows were used for analysis. Results The study included 57 patients, 31 females and 26 males, mean age 63.8±9.8. MRONJ was found in older patients, females mostly under 65 years old, males mostly over 65 years old (p = 0.023). Age distribution was correlated with the neoplasm type, while median ages between the breast neoplasm (58.5 years old) and prostate neoplasm (70 years old) groups were significantly different (p = 0.002). All patients with MRONJ have been previously treated with intravenous zoledronic acid for bone metastasis. Mandibular MRONJ was 2.35 times more frequent than maxillary MRONJ (p = 0.002) and stage II of MRONJ was commonly encountered. Conclusions MRONJ has been found mostly in patients with breast or prostate adenoma cancers with bone metastases who have been treated with intravenous. zoledronic acid and was present especially in the lower jaw, in advanced stages.https://www.rjor.ro/bisphosphonates-related-osteonecrosis-of-the-jaw-in-cancer-patients-epidemiological-study/bisphosphonate-associated osteonecrosis of the jawdiphosphonatesmandibleosteonecrosisneoplasms |
| spellingShingle | George Adrian Ciobanu Adrian Camen Mihaela Ionescu Daniel Vlad Veronica Mercuț Ionela Elisabeta Staicu Gabriel Sebastian Petrescu Adel Aila Asan Sanda Mihaela Popescu BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY Romanian Journal of Oral Rehabilitation bisphosphonate-associated osteonecrosis of the jaw diphosphonates mandible osteonecrosis neoplasms |
| title | BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY |
| title_full | BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY |
| title_fullStr | BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY |
| title_full_unstemmed | BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY |
| title_short | BISPHOSPHONATES RELATED OSTEONECROSIS OF THE JAW IN CANCER PATIENTS – EPIDEMIOLOGICAL STUDY |
| title_sort | bisphosphonates related osteonecrosis of the jaw in cancer patients epidemiological study |
| topic | bisphosphonate-associated osteonecrosis of the jaw diphosphonates mandible osteonecrosis neoplasms |
| url | https://www.rjor.ro/bisphosphonates-related-osteonecrosis-of-the-jaw-in-cancer-patients-epidemiological-study/ |
| work_keys_str_mv | AT georgeadrianciobanu bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT adriancamen bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT mihaelaionescu bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT danielvlad bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT veronicamercut bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT ionelaelisabetastaicu bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT gabrielsebastianpetrescu bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT adelailaasan bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy AT sandamihaelapopescu bisphosphonatesrelatedosteonecrosisofthejawincancerpatientsepidemiologicalstudy |