Bordetella bronchiseptica Colonization Limits Efficacy, but Not Immunogenicity, of Live-Attenuated Influenza Virus Vaccine and Enhances Pathogenesis After Influenza Challenge

Bordetella bronchiseptica Colonization Limits Efficacy, but Not Immunogenicity, of Live-Attenuated Influenza Virus Vaccine and Enhances Pathogenesis After Influenza Challenge

Intranasally administered live-attenuated influenza virus (LAIV) vaccines provide significant protection against heterologous influenza A virus (IAV) challenge. However, LAIV administration can modify the bacterial microbiota in the upper respiratory tract, including alterations in species that caus...

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Bibliographic Details
Main Authors: Holly R. Hughes, Susan L. Brockmeier, Crystal L. Loving
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
influenza vaccine
vaccine
co-infection
efficacy
immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02255/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02255/full

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